6BHE

Crystal structure of SETDB1 with a modified H3 peptide

Summary for 6BHE

• Entry DOI: 10.2210/pdb6bhe/pdb
• Descriptor: Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION, ... (4 entities in total)
• Functional Keywords: structural genomics, epigenetics, histone modification, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q15047 P68431
• Total number of polymer chains: 2
• Total formula weight: 29525.93

Authors

Qin, S.,Tempel, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2017-10-30, release date: 2017-12-06, Last modification date: 2023-11-15)

• Primary citation: Jurkowska, R.Z.,Qin, S.,Kungulovski, G.,Tempel, W.,Liu, Y.,Bashtrykov, P.,Stiefelmaier, J.,Jurkowski, T.P.,Kudithipudi, S.,Weirich, S.,Tamas, R.,Wu, H.,Dombrovski, L.,Loppnau, P.,Reinhardt, R.,Min, J.,Jeltsch, A.; H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.; Nat Commun, 8:2057-2057, 2017; PubMed: 29234025; DOI: 10.1038/s41467-017-02259-9

Experimental method

X-RAY DIFFRACTION (1.35 Å)