7R4X
 
 | | Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | 著者 | Pellegrino, S, Dent, K.C, Spikes, T, Warren, A.J. | | 登録日 | 2022-02-09 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.15 Å) | | 主引用文献 | Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 angstrom resolution.
Nucleic Acids Res., 51, 2023
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6GQB
 | | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | 著者 | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | | 登録日 | 2018-06-07 | | 公開日 | 2018-07-11 | | 最終更新日 | 2021-08-04 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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6GQV
 | | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | | 登録日 | 2018-06-08 | | 公開日 | 2018-07-11 | | 最終更新日 | 2018-08-08 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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4ABY
 | | Crystal structure of Deinococcus radiodurans RecN head domain | | 分子名称: | DNA REPAIR PROTEIN RECN | | 著者 | Pellegrino, S, Radzimanowski, J, de Sanctis, D, McSweeney, S, Timmins, J. | | 登録日 | 2011-12-12 | | 公開日 | 2012-12-12 | | 最終更新日 | 2012-12-26 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural and Functional Characterization of an Smc-Like Protein Recn: New Insights Into Double-Strand Break Repair.
Structure, 20, 2012
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4AD8
 | | Crystal structure of a deletion mutant of Deinococcus radiodurans RecN | | 分子名称: | DNA REPAIR PROTEIN RECN | | 著者 | Pellegrino, S, Radzimanowski, J, de Sanctis, D, McSweeney, S, Timmins, J. | | 登録日 | 2011-12-22 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.998 Å) | | 主引用文献 | Structural and Functional Characterization of an Smc-Like Protein Recn: New Insights Into Double-Strand Break Repair.
Structure, 20, 2012
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4ABX
 | | Crystal structure of Deinococcus radiodurans RecN coiled-coil domain | | 分子名称: | DNA REPAIR PROTEIN RECN | | 著者 | Pellegrino, S, Radzimanowski, J, de Sanctis, D, McSweeney, S, Timmins, J. | | 登録日 | 2011-12-12 | | 公開日 | 2012-12-12 | | 最終更新日 | 2012-12-26 | | 実験手法 | X-RAY DIFFRACTION (2.041 Å) | | 主引用文献 | Structural and Functional Characterization of an Smc-Like Protein Recn: New Insights Into Double-Strand Break Repair.
Structure, 20, 2012
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6HHQ
 | | Crystal structure of compound C45 bound to the yeast 80S ribosome | | 分子名称: | (3~{R})-3-[(1~{S})-2-[(1~{S},4~{a}~{R},6~{S},7~{S},8~{a}~{R})-6,7-bis(chloranyl)-5,5,8~{a}-trimethyl-2-methylidene-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione, 18S ribosomal RNA, 25S ribosomal RNA, ... | | 著者 | Pellegrino, S, Vanderwal, C.D, Yusupov, M. | | 登録日 | 2018-08-28 | | 公開日 | 2019-02-20 | | 最終更新日 | 2019-04-17 | | 実験手法 | X-RAY DIFFRACTION (3.10000038 Å) | | 主引用文献 | Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
Nucleic Acids Res., 47, 2019
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6GQ1
 | | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | 著者 | Pellegrino, S, Demeshkina, N, Mancera-Martinez, E, Melnikov, S, Simonetti, A, Myasnikov, A, Yusupov, M, Yusupova, G, Hashem, Y. | | 登録日 | 2018-06-07 | | 公開日 | 2018-07-11 | | 最終更新日 | 2018-08-08 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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5ON6
 | | Crystal structure of haemanthamine bound to the 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Pellegrino, S, Meyer, M, Yusupova, G, Yusupov, M. | | 登録日 | 2017-08-03 | | 公開日 | 2018-02-28 | | 最終更新日 | 2018-03-14 | | 実験手法 | X-RAY DIFFRACTION (3.10000229 Å) | | 主引用文献 | The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.
Structure, 26, 2018
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5TBW
 | | Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Konst, Z.A, Szklarski, A.R, Pellegrino, S, Michalak, S.E, Meyer, M, Zanette, C, Cencic, R, Nam, S, Horne, D.A, Pelletier, J, Mobley, D.L, Yusupova, G, Yusupov, M, Vanderwal, C.D. | | 登録日 | 2016-09-13 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
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5MEI
 | | Crystal structure of Agelastatin A bound to the 80S ribosome | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | McClary, B, Zinshteyn, B, Meyer, M, Jouanneau, M, Pellegrino, S, Yusupova, G, Schuller, A, Reyes, J.C.P, Lu, J, Luo, C, Dang, Y, Romo, D, Yusupov, M, Green, R, Liu, J.O. | | 登録日 | 2016-11-15 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Cell Chem Biol, 24, 2017
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7QH6
 | | Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 1 | | 分子名称: | 16S ribosomal RNA, 39S ribosomal protein L13, mitochondrial, ... | | 著者 | Rebelo-Guiomar, P, Pellegrino, S, Dent, K.C, Warren, A.J, Minczuk, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Nat Commun, 13, 2022
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7QH7
 | | Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4 | | 分子名称: | 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... | | 著者 | Rebelo-Guiomar, P, Pellegrino, S, Dent, K.C, Warren, A.J, Minczuk, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Nat Commun, 13, 2022
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6SJ6
 | | Cryo-EM structure of 50S-RsfS complex from Staphylococcus aureus | | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | | 著者 | Khusainov, I, Pellegrino, S, Yusupova, G, Yusupov, M, Fatkhullin, B. | | 登録日 | 2019-08-12 | | 公開日 | 2020-04-08 | | 最終更新日 | 2020-07-08 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach.
Nat Commun, 11, 2020
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8B9P
 | | ACE2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-GLY-ARG-GLN-PHE-CYS-HIS-THR-LEU-MET-PRO-ARG-HIS-LEU-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2 | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-10-06 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
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5JWD
 | | Crystal structure of H-2Db in complex with the LCMV-derived GP392-401 peptide | | 分子名称: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | 著者 | Buratto, J, Badia-Martinez, D, Norstrom, M, Sandalova, T, Achour, A. | | 登録日 | 2016-05-12 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structures of H-2Db in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity.
PLoS ONE, 12, 2017
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4L29
 | | Structure of wtMHC class I with NY-ESO1 double mutant | | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ... | | 著者 | Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S. | | 登録日 | 2013-06-04 | | 公開日 | 2013-12-25 | | 最終更新日 | 2014-02-26 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
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4L3C
 | | Structure of HLA-A2 in complex with D76N b2m mutant and NY-ESO1 double mutant | | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ... | | 著者 | Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S. | | 登録日 | 2013-06-05 | | 公開日 | 2013-12-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
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8A3D
 | | Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound | | 分子名称: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 28S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Faille, A, Warren, A.J, Dent, K.C. | | 登録日 | 2022-06-08 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (1.67 Å) | | 主引用文献 | The chemical landscape of the human ribosome at 1.67 angstrom resolution.
Biorxiv, 2023
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4OJ3
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4OJG
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4OJH
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8BN1
 | | The structures of Ace2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-4PH-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2, ... | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-11-11 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
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8BYJ
 | | The structures of Ace2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-HIS-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA, Processed angiotensin-converting enzyme 2, ... | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-12-13 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
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8BFW
 | | The structures of Ace2 in complex with bicyclic peptide inhibitor | | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-HIS-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2 | | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | | 登録日 | 2022-10-27 | | 公開日 | 2023-10-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2.
J.Med.Chem., 66, 2023
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