6RRL
 
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6RRO
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9B33
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9B34
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9B35
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9B36
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9B37
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9B38
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9B39
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7S8B
 | | Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2021-09-17 | | 公開日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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8T1D
 | | Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD | | 分子名称: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-06-02 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
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8T1E
 | | Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... | | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-06-02 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
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8T1F
 | | Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | | 登録日 | 2023-06-02 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
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2JWM
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7LR0
 | | Structure of squirrel TRPV1 in complex with capsaicin | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Osm-9-like TRP channel 1, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-02-15 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
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7LQZ
 | | Structure of squirrel TRPV1 in complex with RTX | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Osm-9-like TRP channel 1, SODIUM ION, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-02-15 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021
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7MIJ
 | | Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-04-17 | | 公開日 | 2021-07-21 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (1.98 Å) | | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nat.Struct.Mol.Biol., 28, 2021
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7MIM
 | | Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-04-17 | | 公開日 | 2021-07-21 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nat.Struct.Mol.Biol., 28, 2021
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7UGG
 | | Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2022-03-24 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine.
Nat Commun, 13, 2022
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1ZNU
 | | Structure of cyclotide Kalata B1 in DPC micelles solution | | 分子名称: | Kalata B1 | | 著者 | Shenkarev, Z.O, Nadezhdin, K.D, Sobol, V.A, Sobol, A.G, Skjeldal, L, Arseniev, A.S. | | 登録日 | 2005-05-12 | | 公開日 | 2006-04-25 | | 最終更新日 | 2020-02-05 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelle.
Febs J., 273, 2006
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7PL4
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7PH8
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7PHT
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6RSM
 | | Solution NMR structure of the peptide 12530 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles | | 分子名称: | peptide 12530 | | 著者 | Talyzina, I.A, Nadezhdin, K.D, Grafskaia, E.N, Arseniev, A.S, Lazarev, V.N. | | 登録日 | 2019-05-21 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens.
Eur.J.Med.Chem., 180, 2019
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8FOB
 | | Cryo-EM structure of human TRPV6 in the open state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2022-12-30 | | 公開日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023
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