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3EBI
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BU of 3ebi by Molmil
Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog
分子名称: (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, GLYCEROL, M1 family aminopeptidase, ...
著者McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C.
登録日2008-08-27
公開日2009-01-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
Proc.Natl.Acad.Sci.USA, 106, 2009
3EBG
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BU of 3ebg by Molmil
Structure of the M1 Alanylaminopeptidase from malaria
分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C.
登録日2008-08-27
公開日2009-01-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
Proc.Natl.Acad.Sci.USA, 106, 2009
3EBH
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BU of 3ebh by Molmil
Structure of the M1 Alanylaminopeptidase from malaria complexed with bestatin
分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, GLYCEROL, M1 family aminopeptidase, ...
著者McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C.
登録日2008-08-27
公開日2009-01-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
Proc.Natl.Acad.Sci.USA, 106, 2009
4F88
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BU of 4f88 by Molmil
X-ray Crystal Structure of PlyC
分子名称: PlyCA, PlyCB
著者McGowan, S, Buckle, A.M, Fischetti, V.A, Nelson, D.C, Whisstock, J.C.
登録日2012-05-17
公開日2012-07-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献X-ray crystal structure of the streptococcal specific phage lysin PlyC.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F87
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BU of 4f87 by Molmil
X-ray Crystal Structure of PlyCB
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, PlyCB
著者McGowan, S, Buckle, A.M, Fischetti, V.A, Nelson, D.C, Whisstock, J.C.
登録日2012-05-17
公開日2012-07-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献X-ray crystal structure of the streptococcal specific phage lysin PlyC.
Proc.Natl.Acad.Sci.USA, 109, 2012
3KQZ
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BU of 3kqz by Molmil
Structure of a protease 2
分子名称: CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ...
著者McGowan, S, Whisstock, J.C.
登録日2009-11-17
公開日2010-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
Proc.Natl.Acad.Sci.USA, 107, 2010
3KQX
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BU of 3kqx by Molmil
Structure of a protease 1
分子名称: CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ...
著者McGowan, S, Whisstock, J.C.
登録日2009-11-17
公開日2010-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
Proc.Natl.Acad.Sci.USA, 107, 2010
3KR4
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BU of 3kr4 by Molmil
Structure of a protease 3
分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, CARBONATE ION, M17 leucyl aminopeptidase, ...
著者McGowan, S, Whisstock, J.C.
登録日2009-11-17
公開日2010-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
Proc.Natl.Acad.Sci.USA, 107, 2010
3KR5
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BU of 3kr5 by Molmil
Structure of a protease 4
分子名称: (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, CARBONATE ION, M17 leucyl aminopeptidase, ...
著者McGowan, S, Whisstock, J.C.
登録日2009-11-17
公開日2010-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
Proc.Natl.Acad.Sci.USA, 107, 2010
8SVL
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BU of 8svl by Molmil
Plasmodium falciparum M1 aminopeptidase bound to MMV1557817
分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者McGowan, S, Drinkwater, N.
登録日2023-05-17
公開日2024-04-24
実験手法X-RAY DIFFRACTION (1.504 Å)
主引用文献Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties.
Mbio, 2024
8SVM
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BU of 8svm by Molmil
Plasmodium falciparum M17 aminopeptidase bound to MMV1557817
分子名称: CARBONATE ION, Leucine aminopeptidase, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-3,3-dimethylbutanamide, ...
著者McGowan, S, Drinkwater, N.
登録日2023-05-17
公開日2024-04-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties.
Mbio, 2024
8SW9
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BU of 8sw9 by Molmil
Plasmodium falciparum M17 (A460S) mutant
分子名称: CARBONATE ION, Leucine aminopeptidase, PENTAETHYLENE GLYCOL, ...
著者McGowan, S, Suraweera, C, Drinkwater, N.
登録日2023-05-17
公開日2024-04-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties.
Mbio, 2024
4K5O
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BU of 4k5o by Molmil
Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者McGowan, S.
登録日2013-04-15
公開日2013-06-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum.
J.Med.Chem., 56, 2013
2DUT
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BU of 2dut by Molmil
Crystal structure of a M-loop deletion variant of MENT in the native conformation
分子名称: Heterochromatin-associated protein MENT
著者Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
登録日2006-07-26
公開日2006-08-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation
Embo J., 25, 2006
3T8V
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BU of 3t8v by Molmil
A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
分子名称: M1 family aminopeptidase, MAGNESIUM ION, N-[(2-{2-[(N-{(2S,3R)-3-amino-4-[4-(benzyloxy)phenyl]-2-hydroxybutanoyl}-L-alanyl)amino]ethoxy}ethoxy)acetyl]-4-benzoyl-L-phenylalanyl-N~6~-hex-5-ynoyllysinamide, ...
著者McGowan, S, Klemba, M, Greebaum, D.C.
登録日2011-08-01
公開日2011-09-28
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Proc.Natl.Acad.Sci.USA, 108, 2011
3T8W
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BU of 3t8w by Molmil
A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
分子名称: CARBONATE ION, M17 leucyl aminopeptidase, N-((2R,3S,6S,18S,21S)-2-amino-18-(4-benzoylbenzyl)-21-carbamoyl-3-hydroxy-6-(naphthalen-2-ylmethyl)-4,7,16,19-tetraoxo-1-phenyl-11,14-dioxa-5,8,17,20-tetraazapentacosan-25-yl)hex-5-ynamide, ...
著者McGowan, S, Klemba, M, Greebaum, D.C.
登録日2011-08-01
公開日2011-09-28
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Proc.Natl.Acad.Sci.USA, 108, 2011
5TZB
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BU of 5tzb by Molmil
Burkholderia sp. beta-aminopeptidase
分子名称: CALCIUM ION, D-aminopeptidase
著者McGowan, S, Drinkwater, N, John, M, Dumsday, G.
登録日2016-11-21
公開日2017-07-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.977 Å)
主引用文献Crystal structure of a beta-aminopeptidase from an Australian Burkholderia sp.
Acta Crystallogr F Struct Biol Commun, 73, 2017
4EME
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BU of 4eme by Molmil
X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase
分子名称: M18 aspartyl aminopeptidase, ZINC ION
著者McGowan, S.
登録日2012-04-11
公開日2012-06-27
最終更新日2013-01-02
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.
J.Mol.Biol., 422, 2012
3Q43
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BU of 3q43 by Molmil
X-ray crystal structure of PfA-M1 bound to bestatin derivative 15
分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者McGowan, S, Greenbaum, D.C.
登録日2010-12-22
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the s1 pocket of the essential malaria m1 metalloaminopeptidase.
J.Med.Chem., 54, 2011
3Q44
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BU of 3q44 by Molmil
X-ray crystal structure of PfA-M1 bound to Bestatin derivative 16
分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者McGowan, S, Greenbaum, D.C.
登録日2010-12-22
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the s1 pocket of the essential malaria m1 metalloaminopeptidase.
J.Med.Chem., 54, 2011
6N7Q
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BU of 6n7q by Molmil
Plasmodium falciparum FVO apical membrane antigen 1 (AMA1) bound to cyclised RON2 peptide
分子名称: Apical membrane antigen-1, RON2 peptide
著者McGowan, S, Drinkwater, N.
登録日2018-11-28
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe.
ChemMedChem, 14, 2019
2H4R
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BU of 2h4r by Molmil
Crystal structure of wildtype MENT in the native conformation
分子名称: Heterochromatin-associated protein MENT
著者Irving, J.A, Whisstock, J.C, Buckle, A.M, McGowan, S.
登録日2006-05-25
公開日2006-07-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
2H4Q
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BU of 2h4q by Molmil
Crystal structure of a M-loop deletion variant of MENT in the cleaved conformation
分子名称: Heterochromatin-associated protein MENT
著者Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
登録日2006-05-25
公開日2006-07-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
2H4P
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BU of 2h4p by Molmil
Crystal structure of wildtype MENT in the cleaved conformation
分子名称: Heterochromatin-associated protein MENT
著者Buckle, A.M, McGowan, S, Irving, J.A, Whisstock, J.C.
登録日2006-05-24
公開日2006-07-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
6N87
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BU of 6n87 by Molmil
Plasmodium falciparum FVO apical membrane antigen 1 (AMA1) bound to MTSL spin-labelled cyclised RON2 peptide
分子名称: Apical membrane antigen-1, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, backbone-cyclised peptide bcRON2hp
著者McGowan, S, Drinkwater, N.
登録日2018-11-28
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.588 Å)
主引用文献Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe.
ChemMedChem, 14, 2019

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