6N87

Plasmodium falciparum FVO apical membrane antigen 1 (AMA1) bound to MTSL spin-labelled cyclised RON2 peptide

Summary for 6N87

• Entry DOI: 10.2210/pdb6n87/pdb
• Related: 6N7Q
• Descriptor: Apical membrane antigen-1, backbone-cyclised peptide bcRON2hp, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ... (4 entities in total)
• Functional Keywords: ama1, apical membrane antigen 1, malaria, ron2, paramagnetic probe, peptide binding protein
• Biological source: Plasmodium falciparum; More
• Total number of polymer chains: 2
• Total formula weight: 40204.11

Authors

McGowan, S.,Drinkwater, N. (deposition date: 2018-11-28, release date: 2019-01-30, Last modification date: 2023-10-11)

• Primary citation: Akter, M.,Drinkwater, N.,Devine, S.M.,Drew, S.C.,Krishnarjuna, B.,Debono, C.O.,Wang, G.,Scanlon, M.J.,Scammells, P.J.,McGowan, S.,MacRaild, C.A.,Norton, R.S.; Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe.; ChemMedChem, 14:603-612, 2019; PubMed: 30653832; DOI: 10.1002/cmdc.201800802

Experimental method

X-RAY DIFFRACTION (1.588 Å)