8SVM

Plasmodium falciparum M17 aminopeptidase bound to MMV1557817

Summary for 8SVM

• Entry DOI: 10.2210/pdb8svm/pdb
• Related: 8SVL
• Descriptor: Leucine aminopeptidase, CARBONATE ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: metallo-exopeptidase; protease inhibitor, malaria, plasmodium, m17 aminopeptidase, hydrolase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 12
• Total formula weight: 719354.80

Authors

McGowan, S.,Drinkwater, N. (deposition date: 2023-05-17, release date: 2024-04-24)

• Primary citation: de Koning-Ward, T.F.,Drinkwater, N.,Edgar, R.C.S.,McGowan, S.,Scammells, P.J.; Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties.; Mbio, 2024

Experimental method

X-RAY DIFFRACTION (2.3 Å)