8SVM

Plasmodium falciparum M17 aminopeptidase bound to MMV1557817

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0019538	biological_process	protein metabolic process
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0019538	biological_process	protein metabolic process
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0070006	molecular_function	metalloaminopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0019538	biological_process	protein metabolic process
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0070006	molecular_function	metalloaminopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0019538	biological_process	protein metabolic process
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
F	0070006	molecular_function	metalloaminopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0019538	biological_process	protein metabolic process
G	0030145	molecular_function	manganese ion binding
G	0046872	molecular_function	metal ion binding
G	0070006	molecular_function	metalloaminopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0019538	biological_process	protein metabolic process
H	0030145	molecular_function	manganese ion binding
H	0046872	molecular_function	metal ion binding
H	0070006	molecular_function	metalloaminopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0019538	biological_process	protein metabolic process
I	0030145	molecular_function	manganese ion binding
I	0046872	molecular_function	metal ion binding
I	0070006	molecular_function	metalloaminopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0019538	biological_process	protein metabolic process
J	0030145	molecular_function	manganese ion binding
J	0046872	molecular_function	metal ion binding
J	0070006	molecular_function	metalloaminopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0019538	biological_process	protein metabolic process
K	0030145	molecular_function	manganese ion binding
K	0046872	molecular_function	metal ion binding
K	0070006	molecular_function	metalloaminopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0019538	biological_process	protein metabolic process
L	0030145	molecular_function	manganese ion binding
L	0046872	molecular_function	metal ion binding
L	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN457-LEU464

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Region: {"description":"L13 loop","evidences":[{"source":"PubMed","id":"35691342","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	24
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P00727","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20133789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21844374","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23713488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25299353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25645579","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35691342","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2021","submissionDatabase":"PDB data bank","title":"Structure of M17 with compound.","authors":["Edgar R.","McGowan S.","Webb C.T."]}},{"source":"PDB","id":"3T8W","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3KQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KR5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R76","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R7M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X2T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RIE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20133789","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23713488","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KR5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35691342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SRV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20133789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21844374","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23713488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25299353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25645579","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35691342","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2021","submissionDatabase":"PDB data bank","title":"Structure of M17 with compound.","authors":["Edgar R.","McGowan S.","Webb C.T."]}},{"source":"PDB","id":"3KQZ","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3T8W","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3KR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KR5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R76","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R7M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X2T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RIE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Site: {"description":"Essential for hexamer stabilization","evidences":[{"source":"PubMed","id":"35691342","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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