8SVM

Plasmodium falciparum M17 aminopeptidase bound to MMV1557817

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Leucine aminopeptidase	polymer	528	58709.0	12	UniProt (Q8IL11) Pfam (PF00883) In PDB	Plasmodium falciparum (malaria parasite P. falciparum)	PfLAP,M17 leucyl aminopeptidase,PfA-M17,PfM17LAP
2	C, J, G, K, D...	CARBONATE ION	non-polymer		60.0	12	Chemie (CO3)
3	F, C, J, G, K...	ZINC ION	non-polymer		65.4	24	Chemie (ZN)
4	F, C, J, G, K...	N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-3,3-dimethylbutanamide	non-polymer		394.4	12	Chemie (WRC)
5	B, I, F, C, J...	PENTAETHYLENE GLYCOL	non-polymer		238.3	28	Chemie (1PE)
6	F, J, C, G, K...	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
7		water	water		18.0	3033	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 84 - 605 (UniProt: Q8IL11)

PDB	External Database	Details
Gln 152	Asn 152	engineered mutation
Gln 515	Asn 515	engineered mutation
Gln 546	Asn 546	engineered mutation
His 606	-	expression tag
His 607	-	expression tag
His 608	-	expression tag
His 609	-	expression tag
His 610	-	expression tag
His 611	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	704507.7
Non-Polymers*	Number of molecules	88
	Total formula weight	14847.1
All*	Total formula weight	719354.8

*Water molecules are not included.