8SVM
Plasmodium falciparum M17 aminopeptidase bound to MMV1557817
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Leucine aminopeptidase | polymer | 528 | 58709.0 | 12 | UniProt (Q8IL11) Pfam (PF00883) | Plasmodium falciparum (malaria parasite P. falciparum) | PfLAP,M17 leucyl aminopeptidase,PfA-M17,PfM17LAP |
| 2 | BA, BC, FB, IC, KA... (C, J, G, K, D...) | CARBONATE ION | non-polymer | 60.0 | 12 | Chemie (CO3) | |||
| 3 | AB, CA, CC, DA, DC... (F, C, J, G, K...) | ZINC ION | non-polymer | 65.4 | 24 | Chemie (ZN) | |||
| 4 | BB, EA, EC, IB, LC... (F, C, J, G, K...) | N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-3,3-dimethylbutanamide | non-polymer | 394.4 | 12 | Chemie (WRC) | |||
| 5 | AA, AC, CB, DB, FA... (B, I, F, C, J...) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 28 | Chemie (1PE) | |||
| 6 | EB, HC, IA, JA, LB... (F, J, C, G, K...) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 7 | AD, BD, CD, DD, ED... (E, F, G, H, I...) | water | water | 18.0 | 3033 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 84 - 605 (UniProt: Q8IL11)
| PDB | External Database | Details |
|---|---|---|
| Gln 152 | Asn 152 | engineered mutation |
| Gln 515 | Asn 515 | engineered mutation |
| Gln 546 | Asn 546 | engineered mutation |
| His 606 | - | expression tag |
| His 607 | - | expression tag |
| His 608 | - | expression tag |
| His 609 | - | expression tag |
| His 610 | - | expression tag |
| His 611 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 704507.7 | |
| Non-Polymers* | Number of molecules | 88 |
| Total formula weight | 14847.1 | |
| All* | Total formula weight | 719354.8 |
