8SVL

Plasmodium falciparum M1 aminopeptidase bound to MMV1557817

Summary for 8SVL

• Entry DOI: 10.2210/pdb8svl/pdb
• Descriptor: M1 family aminopeptidase, ZINC ION, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-3,3-dimethylbutanamide, ... (6 entities in total)
• Functional Keywords: metallo-exopeptidase; protease inhibitor, malaria, plasmodium, m1 aminopeptidase, hydrolase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 1
• Total formula weight: 128413.88

Authors

McGowan, S.,Drinkwater, N. (deposition date: 2023-05-17, release date: 2024-04-24)

• Primary citation: de Koning-Ward, T.F.,Drinkwater, N.,Edgar, R.C.S.,McGowan, S.,Scammells, P.J.; Characterisation of a novel antimalarial agent targeting haemaglobin digestion that shows cross-species reactivity and excellent in vivo properties.; Mbio, 2024

Experimental method

X-RAY DIFFRACTION (1.504 Å)