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8UP6
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BU of 8up6 by Molmil
Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19A) in complex with L-Asp
Descriptor: ASPARTIC ACID, Asparaginase, TETRAETHYLENE GLYCOL
Authors:Lubkowski, J, Wlodawer, A, Zhang, D.
Deposit date:2023-10-21
Release date:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
1ZMH
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BU of 1zmh by Molmil
Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala)
Descriptor: GLYCEROL, HEXAETHYLENE GLYCOL, Neutrophil defensin 2, ...
Authors:Lubkowski, J, Prahl, A, Lu, W.
Deposit date:2005-05-10
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMI
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BU of 1zmi by Molmil
Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group )
Descriptor: GLYCEROL, Neutrophil defensin 2, SULFATE ION
Authors:Lubkowski, J, Prahl, A, Lu, W.
Deposit date:2005-05-10
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMM
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BU of 1zmm by Molmil
Crystal structure of human alpha-defensin-4
Descriptor: Neutrophil defensin 4
Authors:Lubkowski, J, Szyk, A, Lu, W.
Deposit date:2005-05-10
Release date:2006-05-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of human {alpha}-defensins HNP4, HD5, and HD6.
Protein Sci., 15, 2006
1ZMK
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BU of 1zmk by Molmil
Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group
Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 2
Authors:Lubkowski, J, Prahl, A, Lu, W.
Deposit date:2005-05-10
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMP
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BU of 1zmp by Molmil
Crystal structure of human defensin-5
Descriptor: CHLORIDE ION, Defensin 5, GLYCEROL, ...
Authors:Lubkowski, J, Szyk, A, Lu, W.
Deposit date:2005-05-10
Release date:2006-05-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structures of human {alpha}-defensins HNP4, HD5, and HD6.
Protein Sci., 15, 2006
1ZMQ
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BU of 1zmq by Molmil
Crystal structure of human alpha-defensin-6
Descriptor: CHLORIDE ION, Defensin 6
Authors:Lubkowski, J, Szyk, A, Lu, W.
Deposit date:2005-05-10
Release date:2006-05-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human {alpha}-defensins HNP4, HD5, and HD6.
Protein Sci., 15, 2006
2I9A
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BU of 2i9a by Molmil
Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)
Descriptor: PHOSPHATE ION, Urokinase-type plasminogen activator
Authors:Lubkowski, J, Barinka, C.
Deposit date:2006-09-05
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
2I9B
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BU of 2i9b by Molmil
Crystal structure of ATF-urokinase receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Urokinase plasminogen activator surface receptor, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2006-09-05
Release date:2007-01-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J.Mol.Biol., 363, 2006
3FF3
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BU of 3ff3 by Molmil
The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with L-glutamate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2008-12-01
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
Febs J., 276, 2009
3FEE
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BU of 3fee by Molmil
The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with quisqualic acid
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lubkowski, J, Barinka, C, Hlouchova, K.
Deposit date:2008-11-28
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
Febs J., 276, 2009
3FED
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BU of 3fed by Molmil
The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with a transition state analog of Glu-Glu
Descriptor: (2S)-2-{[(S)-[(3S)-3-amino-3-carboxypropyl](hydroxy)phosphoryl]methyl}pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lubkowski, J, Barinka, C, Hlouchova, K.
Deposit date:2008-11-28
Release date:2009-08-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
Febs J., 276, 2009
3BI0
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BU of 3bi0 by Molmil
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a transition state analog of Glu-Glu
Descriptor: (2S)-2-{[(S)-[(3S)-3-amino-3-carboxypropyl](hydroxy)phosphoryl]methyl}pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2007-11-29
Release date:2008-01-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs
J.Mol.Biol., 376, 2008
3BHX
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BU of 3bhx by Molmil
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a transition state analog of Asp-Glu
Descriptor: (2S)-2-{[(S)-(2-carboxyethyl)(hydroxy)phosphoryl]methyl}pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2007-11-29
Release date:2008-01-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs
J.Mol.Biol., 376, 2008
3BXM
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BU of 3bxm by Molmil
Structure of an inactive mutant of human glutamate carboxypeptidase II [GCPII(E424A)] in complex with N-acetyl-Asp-Glu (NAAG)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2008-01-14
Release date:2009-01-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.
Biochemistry, 48, 2009
3D7G
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BU of 3d7g by Molmil
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCMC, a urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2008-05-21
Release date:2008-12-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization
J.Med.Chem., 51, 2008
3D7F
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BU of 3d7f by Molmil
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCIT, a urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2008-05-21
Release date:2008-12-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization
J.Med.Chem., 51, 2008
3D7H
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BU of 3d7h by Molmil
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCIBzL, a urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2008-05-21
Release date:2008-12-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization
J.Med.Chem., 51, 2008
3D7D
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BU of 3d7d by Molmil
A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCFBD, a urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lubkowski, J, Barinka, C.
Deposit date:2008-05-21
Release date:2008-12-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization
J.Med.Chem., 51, 2008
1HG1
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BU of 1hg1 by Molmil
X-ray structure of the complex between Erwinia chrysanthemi L-asparaginase and D-aspartate
Descriptor: D-ASPARTIC ACID, L-ASPARAGINASE
Authors:Lubkowski, J, Wlodawer, A, Kolyani, K.A.
Deposit date:2000-12-08
Release date:2001-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stuctural Basis for the Activity and Substrate Specificity of Erwinia Chrysanthemi L-Asparaginase
Biochemistry, 40, 2001
1HFW
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BU of 1hfw by Molmil
X-ray structure of the complex between Erwinia chrysanthemi L-asparaginase and L-Glutamate
Descriptor: GLUTAMIC ACID, L-ASPARAGINASE
Authors:Lubkowski, J, Wlodawer, A, Kolyani, K.A.
Deposit date:2000-12-08
Release date:2001-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stuctural Basis for the Activity and Substrate Specificity of Erwinia Chrysanthemi L-Asparaginase
Biochemistry, 40, 2001
1HG0
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BU of 1hg0 by Molmil
X-ray structure of the complex between Erwinia chrysanthemi L-asparaginase and succinic acid
Descriptor: L-ASPARAGINASE, SUCCINIC ACID
Authors:Lubkowski, J, Wlodawer, A, Kolyani, K.A.
Deposit date:2000-12-08
Release date:2001-08-07
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Stuctural Basis for the Activity and Substrate Specificity of Erwinia Chrysanthemi L-Asparaginase
Biochemistry, 40, 2001
1HFK
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BU of 1hfk by Molmil
Asparaginase from Erwinia chrysanthemi, hexagonal form with weak sulfate
Descriptor: L-ASPARAGINE AMIDOHYDROLASE, SULFATE ION
Authors:Lubkowski, J, Palm, G.J, Kozak, M, Jaskolski, M, Wlodawer, A.
Deposit date:2000-12-05
Release date:2000-12-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structures of Two Highly Homologous Bacterial L-Asparaginases: A Case of Enantiomorphic Space Groups
Acta Crystallogr.,Sect.D, 57, 2001
2NLF
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BU of 2nlf by Molmil
Human beta-defensin-1 (Mutant Leu13Glu)
Descriptor: Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007
2NLD
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BU of 2nld by Molmil
Human beta-defensin-1 (Mutant Gln11Ala)
Descriptor: ACETATE ION, Beta-defensin 1, SULFATE ION
Authors:Lubkowski, J, Pazgier, M.
Deposit date:2006-10-20
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Studies of the Biological Properties of Human beta-Defensin 1.
J.Biol.Chem., 282, 2007

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