3FF3

The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with L-glutamate

Summary for 3FF3

Entry DOI	10.2210/pdb3ff3/pdb
Related	3FEC 3FED 3FEE
Descriptor	Glutamate carboxypeptidase III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	metallopeptidase; bimetallic active site; n-glycosylation; calcium cation; chloride anion; zinc ions, carboxypeptidase, dipeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane
Biological source	Homo sapiens (man)
Total number of polymer chains	1
Total formula weight	81842.55
Authors	Lubkowski, J.,Barinka, C. (deposition date: 2008-12-01, release date: 2009-08-25, Last modification date: 2023-09-06)
Primary citation	Hlouchova, K.,Barinka, C.,Konvalinka, J.,Lubkowski, J. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III Febs J., 276:4448-4462, 2009 Cited by PubMed: 19678840 DOI: 10.1111/j.1742-4658.2009.07152.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.37 Å)

Structure validation