3BI0

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a transition state analog of Glu-Glu

Summary for 3BI0

Entry DOI	10.2210/pdb3bi0/pdb
Related	3BHX 3BI1
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase ii; naaladase, dipeptidase, glycoprotein, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
Total number of polymer chains	1
Total formula weight	83062.11
Authors	Lubkowski, J.,Barinka, C. (deposition date: 2007-11-29, release date: 2008-01-08, Last modification date: 2023-08-30)
Primary citation	Barinka, C.,Hlouchova, K.,Rovenska, M.,Majer, P.,Dauter, M.,Hin, N.,Ko, Y.S.,Tsukamoto, T.,Slusher, B.S.,Konvalinka, J.,Lubkowski, J. Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs J.Mol.Biol., 376:1438-1450, 2008 Cited by PubMed: 18234225 DOI: 10.1016/j.jmb.2007.12.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation