Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3D7F

A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DCIT, a urea-based inhibitor

Summary for 3D7F
Entry DOI10.2210/pdb3d7f/pdb
Related3D7D 3D7G 3D7H
DescriptorGlutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywordsprostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase ii; naaladase, dcit, urea-based inhibitor, carboxypeptidase, dipeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane
Biological sourceHomo sapiens
Cellular locationCell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
Total number of polymer chains1
Total formula weight83393.24
Authors
Lubkowski, J.,Barinka, C. (deposition date: 2008-05-21, release date: 2008-12-30, Last modification date: 2023-08-30)
Primary citationBarinka, C.,Byun, Y.,Dusich, C.L.,Banerjee, S.R.,Chen, Y.,Castanares, M.,Kozikowski, A.P.,Mease, R.C.,Pomper, M.G.,Lubkowski, J.
Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization
J.Med.Chem., 51:7737-7743, 2008
Cited by
PubMed: 19053759
DOI: 10.1021/jm800765e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.54 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon