3MAT
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![BU of 3mat by Molmil](/molmil-images/mine/3mat) | E.COLI METHIONINE AMINOPEPTIDASE TRANSITION-STATE INHIBITOR COMPLEX | Descriptor: | COBALT (II) ION, METHIONINE AMINOPEPTIDASE, SODIUM ION, ... | Authors: | Lowther, W.T, Orville, A.M, Madden, D.T, Lim, S, Rich, D.H, Matthews, B.W. | Deposit date: | 1999-03-29 | Release date: | 1999-06-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis. Biochemistry, 38, 1999
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4MAT
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![BU of 4mat by Molmil](/molmil-images/mine/4mat) | E.COLI METHIONINE AMINOPEPTIDASE HIS79ALA MUTANT | Descriptor: | PROTEIN (METHIONINE AMINOPEPTIDASE), SODIUM ION | Authors: | Lowther, W.T, Orville, A.M, Madden, D.T, Lim, S, Rich, D.H, Matthews, B.W. | Deposit date: | 1999-03-29 | Release date: | 1999-06-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis. Biochemistry, 38, 1999
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1L1D
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![BU of 1l1d by Molmil](/molmil-images/mine/1l1d) | Crystal structure of the C-terminal methionine sulfoxide reductase domain (MsrB) of N. gonorrhoeae pilB | Descriptor: | CACODYLATE ION, peptide methionine sulfoxide reductase | Authors: | Lowther, W.T, Weissbach, H, Etienne, F, Brot, N, Matthews, B.W. | Deposit date: | 2002-02-15 | Release date: | 2002-05-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB. Nat.Struct.Biol., 9, 2002
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8FW6
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![BU of 8fw6 by Molmil](/molmil-images/mine/8fw6) | Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336 | Descriptor: | (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | Authors: | Lowther, W.T, Gumpena, R. | Deposit date: | 2023-01-20 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Human Lactate Dehydrogenase A in complex with inhibitor CHK-336 To Be Published
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2MAT
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![BU of 2mat by Molmil](/molmil-images/mine/2mat) | E.COLI METHIONINE AMINOPEPTIDASE AT 1.9 ANGSTROM RESOLUTION | Descriptor: | COBALT (II) ION, PROTEIN (METHIONINE AMINOPEPTIDASE), SODIUM ION | Authors: | Lowther, W.T, Orville, A.M, Madden, D.T, Lim, S, Rich, D.H, Matthews, B.W. | Deposit date: | 1999-03-29 | Release date: | 1999-06-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis. Biochemistry, 38, 1999
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1FVA
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![BU of 1fva by Molmil](/molmil-images/mine/1fva) | CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE | Descriptor: | PEPTIDE METHIONINE SULFOXIDE REDUCTASE | Authors: | Lowther, W.T, Brot, N, Weissbach, H, Matthews, B.W. | Deposit date: | 2000-09-19 | Release date: | 2000-11-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. Biochemistry, 39, 2000
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1FVG
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![BU of 1fvg by Molmil](/molmil-images/mine/1fvg) | CRYSTAL STRUCTURE OF BOVINE PEPTIDE METHIONINE SULFOXIDE REDUCTASE | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PEPTIDE METHIONINE SULFOXIDE REDUCTASE | Authors: | Lowther, W.T, Brot, N, Weissbach, H, Matthews, B.W. | Deposit date: | 2000-09-19 | Release date: | 2000-11-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. Biochemistry, 39, 2000
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1C21
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![BU of 1c21 by Molmil](/molmil-images/mine/1c21) | E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE COMPLEX | Descriptor: | COBALT (II) ION, METHIONINE, METHIONINE AMINOPEPTIDASE, ... | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | Deposit date: | 1999-07-22 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. Biochemistry, 38, 1999
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1C22
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![BU of 1c22 by Molmil](/molmil-images/mine/1c22) | E. COLI METHIONINE AMINOPEPTIDASE: TRIFLUOROMETHIONINE COMPLEX | Descriptor: | 2-AMINO-4-TRIFLUOROMETHYLSULFANYL-BUTYRIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | Deposit date: | 1999-07-22 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. Biochemistry, 38, 1999
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1C27
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![BU of 1c27 by Molmil](/molmil-images/mine/1c27) | E. COLI METHIONINE AMINOPEPTIDASE:NORLEUCINE PHOSPHONATE COMPLEX | Descriptor: | (1-AMINO-PENTYL)-PHOSPHONIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | Deposit date: | 1999-07-22 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. Biochemistry, 38, 1999
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1C23
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![BU of 1c23 by Molmil](/molmil-images/mine/1c23) | E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHONATE COMPLEX | Descriptor: | (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | Deposit date: | 1999-07-22 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. Biochemistry, 38, 1999
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1C24
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![BU of 1c24 by Molmil](/molmil-images/mine/1c24) | E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHINATE COMPLEX | Descriptor: | (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC ACID, COBALT (II) ION, METHIONINE AMINOPEPTIDASE, ... | Authors: | Lowther, W.T, Zhang, Y, Sampson, P.B, Honek, J.F, Matthews, B.W. | Deposit date: | 1999-07-22 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. Biochemistry, 38, 1999
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6WSK
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![BU of 6wsk by Molmil](/molmil-images/mine/6wsk) | |
3CYI
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![BU of 3cyi by Molmil](/molmil-images/mine/3cyi) | Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Sulfiredoxin-1 | Authors: | Jonsson, T.J, Murray, M.S, Johnson, L.C, Lowther, W.T. | Deposit date: | 2008-04-25 | Release date: | 2008-07-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Reduction of Cysteine Sulfinic Acid in Peroxiredoxin by Sulfiredoxin Proceeds Directly through a Sulfinic Phosphoryl Ester Intermediate. J.Biol.Chem., 283, 2008
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7LJ1
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![BU of 7lj1 by Molmil](/molmil-images/mine/7lj1) | Human Prx1-Srx Decameric Complex | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Forshaw, T.E, Reisz, J.A, Nelson, K.J, Gumpena, R, Lawson, J.R, Jonsson, T, Wu, H, Clodfelter, J.E, Johnson, L, Furdui, C.M, Lowther, W.T. | Deposit date: | 2021-01-28 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State. Antioxidants (Basel), 10, 2021
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7M2N
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![BU of 7m2n by Molmil](/molmil-images/mine/7m2n) | Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15 | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, ... | Authors: | Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T. | Deposit date: | 2021-03-17 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria ACS Medicinal Chemistry Letters, 12, 2021
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7M2O
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![BU of 7m2o by Molmil](/molmil-images/mine/7m2o) | Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15 | Descriptor: | 1,2-ETHANEDIOL, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | Authors: | Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T. | Deposit date: | 2021-03-17 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria ACS Medicinal Chemistry Letters, 12, 2021
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3S5N
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![BU of 3s5n by Molmil](/molmil-images/mine/3s5n) | Crystal Structure of Human 4-hydroxy-2-oxoglutarate Aldolase | Descriptor: | 1,2-ETHANEDIOL, 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, ... | Authors: | Riedel, T.J, Lowther, W.T. | Deposit date: | 2011-05-23 | Release date: | 2011-10-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria. Plos One, 6, 2011
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3S5O
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![BU of 3s5o by Molmil](/molmil-images/mine/3s5o) | |
2H30
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![BU of 2h30 by Molmil](/molmil-images/mine/2h30) | Crystal structure of the N-terminal domain of PilB from Neisseria gonorrhoeae | Descriptor: | Peptide methionine sulfoxide reductase msrA/msrB | Authors: | Brot, N, Collet, J.F, Johnson, L.C, Jonsson, T.J, Weissbach, H, Lowther, W.T. | Deposit date: | 2006-05-20 | Release date: | 2006-08-22 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Thioredoxin Domain of Neisseria gonorrhoeae PilB Can Use Electrons from DsbD to Reduce Downstream Methionine Sulfoxide Reductases. J.Biol.Chem., 281, 2006
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5IJT
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![BU of 5ijt by Molmil](/molmil-images/mine/5ijt) | |
4XJV
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![BU of 4xjv by Molmil](/molmil-images/mine/4xjv) | Crystal structure of human thioesterase 2 | Descriptor: | CHLORIDE ION, S-acyl fatty acid synthase thioesterase, medium chain | Authors: | Ritchie, M.K, Kridel, S.J, Lowther, W.T. | Deposit date: | 2015-01-09 | Release date: | 2015-12-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. J.Biol.Chem., 291, 2016
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1XW4
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![BU of 1xw4 by Molmil](/molmil-images/mine/1xw4) | Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Sulfiredoxin | Authors: | Murray, M.S, Jonsson, T.J, Johnson, L.C, Poole, L.B, Lowther, W.T. | Deposit date: | 2004-10-29 | Release date: | 2005-05-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. Biochemistry, 44, 2005
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1XW3
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![BU of 1xw3 by Molmil](/molmil-images/mine/1xw3) | Crystal Structure of Human Sulfiredoxin (Srx) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, SULFIREDOXIN | Authors: | Murray, M.S, Jonsson, T.J, Johnson, L.C, Poole, L.B, Lowther, W.T. | Deposit date: | 2004-10-29 | Release date: | 2005-05-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. Biochemistry, 44, 2005
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3HY2
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![BU of 3hy2 by Molmil](/molmil-images/mine/3hy2) | Crystal Structure of Sulfiredoxin in Complex with Peroxiredoxin I and ATP:Mg2+ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxiredoxin-1, ... | Authors: | Jonsson, T.J, Johnson, L.C, Lowther, W.T. | Deposit date: | 2009-06-22 | Release date: | 2009-10-06 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Protein Engineering of the Quaternary Sulfiredoxin-Peroxiredoxin Enzyme-Substrate Complex Reveals the Molecular Basis for Cysteine Sulfinic Acid Phosphorylation J.Biol.Chem., 284, 2009
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