3CIJ
 
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4DBL
 | | Crystal structure of E159Q mutant of BtuCDF | | Descriptor: | PHOSPHATE ION, SULFATE ION, Vitamin B12 import ATP-binding protein BtuD, ... | | Authors: | Korkhov, V.M, Mireku, S.M, Hvorup, R.N, Locher, K.P. | | Deposit date: | 2012-01-16 | | Release date: | 2012-03-07 | | Last modified: | 2012-05-23 | | Method: | X-RAY DIFFRACTION (3.493 Å) | | Cite: | Asymmetric states of vitamin B12 transporter BtuCD are not discriminated by its cognate substrate binding protein BtuF.
Febs Lett., 586, 2012
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5NO0
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5OGL
 | | Structure of bacterial oligosaccharyltransferase PglB in complex with an acceptor peptide and an lipid-linked oligosaccharide analog | | Descriptor: | MANGANESE (II) ION, SODIUM ION, Substrate mimicking peptide, ... | | Authors: | Napiorkowska, M, Boilevin, J, Sovdat, T, Darbre, T, Reymond, J.-L, Aebi, M, Locher, K.P. | | Deposit date: | 2017-07-13 | | Release date: | 2017-10-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase.
Nat. Struct. Mol. Biol., 24, 2017
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5NRP
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5NJ3
 | | Structure of an ABC transporter: complete structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | | Authors: | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | | Deposit date: | 2017-03-28 | | Release date: | 2017-06-07 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
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5NIV
 | | Crystal structure of 5D3 Fab | | Descriptor: | Heavy chain of 5D3 Fab, Light chain of 5D3 Fab | | Authors: | Manolaridis, I, Locher, K.P. | | Deposit date: | 2017-03-27 | | Release date: | 2017-06-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.498 Å) | | Cite: | Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
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5NP4
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5NSA
 | | Beta domain of human transcobalamin bound to Co-beta-[2-(2,4-difluorophenyl)ethinyl]cobalamin | | Descriptor: | 1-ethynyl-2,4-difluorobenzene, CALCIUM ION, COBALAMIN, ... | | Authors: | Bloch, J.S, Ruetz, M, Krautler, B, Locher, K.P. | | Deposit date: | 2017-04-25 | | Release date: | 2017-09-27 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (1.273 Å) | | Cite: | Structure of the human transcobalamin beta domain in four distinct states.
PLoS ONE, 12, 2017
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5OVW
 | | Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli | | Descriptor: | GLYCEROL, Nanobody, Vitamin B12-binding protein | | Authors: | Mireku, S.A, Sauer, M.M, Glockshuber, R, Locher, K.P. | | Deposit date: | 2017-08-30 | | Release date: | 2017-11-08 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (2.653 Å) | | Cite: | Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD.
Sci Rep, 7, 2017
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4G1U
 | | X-ray structure of the bacterial heme transporter HmuUV from Yersinia pestis | | Descriptor: | Hemin import ATP-binding protein HmuV, Hemin transport system permease protein hmuU, PHOSPHATE ION | | Authors: | Woo, J.-S, Goetz, B.A, Zeltina, A, Locher, K.P. | | Deposit date: | 2012-07-11 | | Release date: | 2012-12-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.008 Å) | | Cite: | X-ray structure of the Yersinia pestis heme transporter HmuUV.
Nat.Struct.Mol.Biol., 19, 2012
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4ZRP
 | | TC:CD320 | | Descriptor: | CALCIUM ION, CD320 antigen, CYANOCOBALAMIN, ... | | Authors: | Alam, A, Locher, K.P. | | Deposit date: | 2015-05-12 | | Release date: | 2016-07-20 | | Last modified: | 2021-08-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis of transcobalamin recognition by human CD320 receptor.
Nat Commun, 7, 2016
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5C73
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4FI3
 | | Structure of vitamin B12 transporter BtuCD-F in a nucleotide-bound state | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Vitamin B12 import ATP-binding protein BtuD, ... | | Authors: | Korkhov, V.M, Mireku, S.A, Locher, K.P. | | Deposit date: | 2012-06-07 | | Release date: | 2012-09-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.466 Å) | | Cite: | Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F.
Nature, 490, 2012
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4ZRQ
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5C76
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5C78
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7OJ8
 | | ABCG2 E1S turnover-2 state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | | Authors: | Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | Deposit date: | 2021-05-14 | | Release date: | 2021-07-21 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7OJH
 | | ABCG2 topotecan turnover-1 state | | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | Deposit date: | 2021-05-15 | | Release date: | 2021-07-21 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7OJI
 | | ABCG2 topotecan turnover-2 state | | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | Deposit date: | 2021-05-16 | | Release date: | 2021-07-21 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7NIU
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7NIV
 | | Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab and QA2-Fab (phosphatidylcholine-bound, occluded conformation) | | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment light chain, CHOLESTEROL, ... | | Authors: | Nosol, K, Locher, K.P. | | Deposit date: | 2021-02-14 | | Release date: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7NIW
 | | Nanodisc reconstituted human ABCB4 in complex with 4B1-Fab (posaconazole-bound, inward-open conformation) | | Descriptor: | 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4B1 Fab-fragment heavy chain, 4B1 Fab-fragment light chain, ... | | Authors: | Nosol, K, Locher, K.P. | | Deposit date: | 2021-02-14 | | Release date: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7O9W
 | | Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | | Descriptor: | Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ... | | Authors: | Nosol, K, Locher, K.P. | | Deposit date: | 2021-04-17 | | Release date: | 2022-01-12 | | Last modified: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
J.Med.Chem., 65, 2022
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7OCI
 | | Cryo-EM structure of yeast Ost6p containing oligosaccharyltransferase complex | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wild, R, Neuhaus, J.D, Eyring, J, Irobalieva, R.N, Kowal, J, Lin, C.W, Locher, K.P, Aebi, M. | | Deposit date: | 2021-04-27 | | Release date: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases.
Glycobiology, 31, 2021
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