6NY3
 
 | | CasX ternary complex with 30bp target DNA | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6NY2
 | | CasX-gRNA-DNA(45bp) state I | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6NY1
 | | CasX-gRNA-DNA(30bp) State II | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6O1O
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3LE6
 | | The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor | | 分子名称: | 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine, Cell division protein kinase 2 | | 著者 | Lukacs, C.M, Swain, A, Crowther, R.L, Kammlott, R.U, Liu, J.J. | | 登録日 | 2010-01-14 | | 公開日 | 2010-11-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
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6P7M
 | | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) | | 分子名称: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | | 著者 | Knott, G.J, Liu, J.J, Doudna, J.A. | | 登録日 | 2019-06-06 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
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6P7N
 | | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (2:2 complex) | | 分子名称: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | | 著者 | Knott, G.J, Liu, J.J, Doudna, J.A. | | 登録日 | 2019-06-06 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Elife, 8, 2019
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3U7D
 | | Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1) cytoplasmic tail | | 分子名称: | Krev interaction trapped protein 1, Protein HEG homolog 1 | | 著者 | Gingras, A.R, Liu, J.J, Ginsberg, M.H, Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) | | 登録日 | 2011-10-13 | | 公開日 | 2012-09-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.
J.Cell Biol., 199, 2012
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5YFP
 | | Cryo-EM Structure of the Exocyst Complex | | 分子名称: | Exocyst complex component EXO70, Exocyst complex component EXO84, Exocyst complex component SEC10, ... | | 著者 | Mei, K, Li, Y, Wang, S, Shao, G, Wang, J, Ding, Y, Luo, G, Yue, P, Liu, J.J, Wang, X, Dong, M.Q, Guo, W, Wang, H.W. | | 登録日 | 2017-09-21 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Cryo-EM structure of the exocyst complex
Nat. Struct. Mol. Biol., 25, 2018
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6MCC
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6MCB
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5VZL
 | | cryo-EM structure of the Cas9-sgRNA-AcrIIA4 anti-CRISPR complex | | 分子名称: | CRISPR-associated endonuclease Cas9, phage anti-CRISPR AcrIIA4, single guide RNA (116-MER) | | 著者 | Jiang, F, Liu, J.J, Nogales, E, Doudna, J.A. | | 登録日 | 2017-05-29 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Disabling Cas9 by an anti-CRISPR DNA mimic.
Sci Adv, 3, 2017
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5WFE
 | | Cas1-Cas2-IHF-DNA holo-complex | | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | 著者 | Wright, A.V, Liu, J.J, Nogales, E, Doudna, J.A. | | 登録日 | 2017-07-11 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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5G06
 | | Cryo-EM structure of yeast cytoplasmic exosome | | 分子名称: | EXOSOME COMPLEX COMPONENT CSL4, EXOSOME COMPLEX COMPONENT MTR3, EXOSOME COMPLEX COMPONENT RRP4, ... | | 著者 | Liu, J.J, Niu, C.Y, Wu, Y, Tan, D, Wang, Y, Ye, M.D, Liu, Y, Zhao, W.W, Zhou, K, Liu, Q.S, Dai, J.B, Yang, X.R, Dong, M.Q, Huang, N, Wang, H.W. | | 登録日 | 2016-03-17 | | 公開日 | 2016-06-15 | | 最終更新日 | 2017-08-02 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryoem Structure of Yeast Cytoplasmic Exosome Complex.
Cell Res., 26, 2016
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4QOC
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4QO4
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4J3E
 | | The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a | | 分子名称: | 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | | 著者 | Graves, B.J, Lukacs, C.M, Kammlott, R.U, Crowther, R. | | 登録日 | 2013-02-05 | | 公開日 | 2013-04-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ACS Med Chem Lett, 4, 2013
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5GRS
 | | Complex structure of the fission yeast SREBP-SCAP binding domains | | 分子名称: | Sterol regulatory element-binding protein 1, Sterol regulatory element-binding protein cleavage-activating protein | | 著者 | Gong, X, Qian, H.W, Wu, J.P, Yan, N. | | 登録日 | 2016-08-12 | | 公開日 | 2016-12-14 | | 最終更新日 | 2019-10-23 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
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5GPD
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8IBY
 | | Structure of R2 with 5'ORF | | 分子名称: | 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION | | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | | 登録日 | 2023-02-10 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
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8IBW
 | | Structure of R2 with 3'UTR and DNA in binding state | | 分子名称: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | | 登録日 | 2023-02-10 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
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8IBX
 | | Structure of R2 with 3'UTR and DNA in unwinding state | | 分子名称: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | | 登録日 | 2023-02-10 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
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8IBZ
 | | Structure of R2 with 5'ORF and 3'UTR | | 分子名称: | 5ORF-linker-3UTR, Reverse transcriptase-like protein, ZINC ION | | 著者 | Deng, P, Tan, S, Wang, J, Liu, J.J. | | 登録日 | 2023-02-10 | | 公開日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
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5EJ9
 | | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min | | 分子名称: | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, FORMIC ACID, GLYCEROL, ... | | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | | 登録日 | 2015-11-01 | | 公開日 | 2016-06-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
J.Am.Chem.Soc., 138, 2016
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5EJA
 | | EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and soaked with isochorismate for 7 min | | 分子名称: | (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, GLYCEROL, ... | | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | | 登録日 | 2015-11-01 | | 公開日 | 2016-06-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
J.Am.Chem.Soc., 138, 2016
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