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3LE6

The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor

Summary for 3LE6
Entry DOI10.2210/pdb3le6/pdb
DescriptorCell division protein kinase 2, 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine (3 entities in total)
Functional Keywordscyclin-dependent kinase 2 drug design, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight34328.24
Authors
Lukacs, C.M.,Swain, A.,Crowther, R.L.,Kammlott, R.U.,Liu, J.J. (deposition date: 2010-01-14, release date: 2010-11-17, Last modification date: 2024-02-21)
Primary citationLiu, J.J.,Daniewski, I.,Ding, Q.,Higgins, B.,Ju, G.,Kolinsky, K.,Konzelmann, F.,Lukacs, C.,Pizzolato, G.,Rossman, P.,Swain, A.,Thakkar, K.,Wei, C.C.,Miklowski, D.,Yang, H.,Yin, X.,Wovkulich, P.M.
Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.
Bioorg.Med.Chem.Lett., 20:5984-5987, 2010
Cited by
PubMed: 20832307
DOI: 10.1016/j.bmcl.2010.08.079
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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