4J3E
The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
Summary for 4J3E
Entry DOI | 10.2210/pdb4j3e/pdb |
Related | 1RV1 4IPF |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | mdm2, protein-protein interaction, imidazoline, ligase-antagonist complex, e3 ubiquitin ligase, p53, nucleus, ligase/antagonist |
Biological source | Xenopus laevis (clawed frog,common platanna,platanna) |
Cellular location | Nucleus, nucleoplasm (By similarity): P56273 |
Total number of polymer chains | 1 |
Total formula weight | 10640.17 |
Authors | Graves, B.J.,Lukacs, C.M.,Kammlott, R.U.,Crowther, R. (deposition date: 2013-02-05, release date: 2013-04-24, Last modification date: 2024-02-28) |
Primary citation | Vu, B.,Wovkulich, P.,Pizzolato, G.,Lovey, A.,Ding, Q.,Jiang, N.,Liu, J.J.,Zhao, C.,Glenn, K.,Wen, Y.,Tovar, C.,Packman, K.,Vassilev, L.,Graves, B. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett, 4:466-469, 2013 Cited by PubMed: 24900694DOI: 10.1021/ml4000657 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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