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4J3E

The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a

Summary for 4J3E
Entry DOI10.2210/pdb4j3e/pdb
Related1RV1 4IPF
DescriptorE3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, SULFATE ION, ... (4 entities in total)
Functional Keywordsmdm2, protein-protein interaction, imidazoline, ligase-antagonist complex, e3 ubiquitin ligase, p53, nucleus, ligase/antagonist
Biological sourceXenopus laevis (clawed frog,common platanna,platanna)
Cellular locationNucleus, nucleoplasm (By similarity): P56273
Total number of polymer chains1
Total formula weight10640.17
Authors
Graves, B.J.,Lukacs, C.M.,Kammlott, R.U.,Crowther, R. (deposition date: 2013-02-05, release date: 2013-04-24, Last modification date: 2024-02-28)
Primary citationVu, B.,Wovkulich, P.,Pizzolato, G.,Lovey, A.,Ding, Q.,Jiang, N.,Liu, J.J.,Zhao, C.,Glenn, K.,Wen, Y.,Tovar, C.,Packman, K.,Vassilev, L.,Graves, B.
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ACS Med Chem Lett, 4:466-469, 2013
Cited by
PubMed: 24900694
DOI: 10.1021/ml4000657
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.91 Å)
Structure validation

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