4J3E

The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NUT A 201

Chain	Residue
A	LEU50
A	ILE95
A	TYR96
A	HOH306
A	HOH308
A	HOH347
A	LEU53
A	GLY54
A	GLN55
A	GLN55
A	ILE57
A	MET58
A	VAL89
A	HIS92

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	MET20
A	ASN75
A	GLU91
A	HIS92
A	ARG93
A	ARG94
A	HOH311
A	HOH335
A	HOH341
A	HOH388

---