7U4J
| Crystal structure of human GPX4-U46C-R152H in complex with TMT10 | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4M
| Crystal structure of human GPX4-U46C in complex with LOC1886 | Descriptor: | 1,2-ETHANEDIOL, 4-methoxy-1H-indole-2-carbaldehyde, Phospholipid hydroperoxide glutathione peroxidase | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2022-12-28 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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7U4L
| Crystal structure of human GPX4-U46C in complex with MAC-5576 | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase, thiophene-2-carbaldehyde | Authors: | Forouhar, F, Liu, H, Lin, A.J, Wang, Q, Polychronidou, V, Soni, R.K, Xia, X, Stockwell, B.R. | Deposit date: | 2022-02-28 | Release date: | 2022-12-07 | Last modified: | 2022-12-28 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol, 29, 2022
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8I4L
| Capsid structure of the Cyanophage P-SCSP1u | Descriptor: | The capsid protein(gp 19) of P-SCSP1u | Authors: | Liu, H, Dang, S. | Deposit date: | 2023-01-19 | Release date: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Cryo-EM structure of cyanophage P-SCSP1u offers insights into DNA gating and evolution of T7-like viruses Nat Commun, 14, 2023
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8I4M
| Portal-tail complex structure of the Cyanophage P-SCSP1u | Descriptor: | Adaptor protein(gp22) of the cyanophage P-SCSP1u, Fiber protein(gp 28) of the cyanophage P-SCSP1u, Nozzle protein(gp 23) of the cyanophage P-SCSP1u, ... | Authors: | Liu, H, Dang, S. | Deposit date: | 2023-01-19 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.81 Å) | Cite: | Cryo-EM structure of cyanophage P-SCSP1u offers insights into DNA gating and evolution of T7-like viruses. Nat Commun, 14, 2023
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7L8L
| Crystal structure of human R152H GPX4-U46C | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION | Authors: | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | Deposit date: | 2020-12-31 | Release date: | 2021-12-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8Q
| Crystal structure of human GPX4-U46C with oxidized Cys-46 | Descriptor: | ACETATE ION, Phospholipid hydroperoxide glutathione peroxidase | Authors: | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | Deposit date: | 2020-12-31 | Release date: | 2021-12-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8M
| Crystal structure of human GPX4-U46C mutant K48L | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase | Authors: | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | Deposit date: | 2020-12-31 | Release date: | 2021-12-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8R
| Crystal structure of human GPX4-U46C mutant K48A | Descriptor: | Isoform Cytoplasmic of Phospholipid hydroperoxide glutathione peroxidase, THIOCYANATE ION | Authors: | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | Deposit date: | 2020-12-31 | Release date: | 2021-12-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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7L8K
| Crystal structure of human GPX4-U46C | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, PHOSPHATE ION, ... | Authors: | Forouhar, F, Liu, H, Seibt, T, Saneto, R, Wigby, K, Friedman, J, Xia, X, Shchepinov, M.S, Ramesh, S, Conrad, M, Stockwell, B.R. | Deposit date: | 2020-12-31 | Release date: | 2021-12-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Patient-derived variant of GPX4 reveals the structural basis for its catalytic activity and degradation mechanism Nat.Chem.Biol., 2021
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5YJH
| Structural insights into periostin functions | Descriptor: | CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Liu, H, Liu, J, Xu, F. | Deposit date: | 2017-10-10 | Release date: | 2018-05-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.957 Å) | Cite: | Structural characterizations of human periostin dimerization and cysteinylation. FEBS Lett., 592, 2018
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5YJG
| Structural insights into periostin functions | Descriptor: | CALCIUM ION, CHLORIDE ION, CYSTEINE, ... | Authors: | Liu, H, Liu, J, Xu, F. | Deposit date: | 2017-10-10 | Release date: | 2018-05-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Structural characterizations of human periostin dimerization and cysteinylation. FEBS Lett., 592, 2018
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5XGP
| structure of Sizzled from Xenopus laevis at 2.08 angstroms resolution | Descriptor: | CHLORIDE ION, SULFATE ION, Secreted Xwnt8 inhibitor sizzled | Authors: | Liu, H, Li, Z, Xu, F. | Deposit date: | 2017-04-15 | Release date: | 2017-08-23 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.077 Å) | Cite: | The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted Frizzled-related proteins J. Biol. Chem., 292, 2017
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5Y4M
| Discoidin domain of human CASPR2 | Descriptor: | 1,2-ETHANEDIOL, human CASPR2 Disc domain | Authors: | Liu, H, Xu, F, Zhang, J, Liang, W. | Deposit date: | 2017-08-04 | Release date: | 2018-08-08 | Last modified: | 2019-02-20 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition. J. Autoimmun., 96, 2019
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5ZVS
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5ZVT
| Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly | Descriptor: | C-terminus of outer capsid protein VP5, Core protein VP6, MYRISTIC ACID, ... | Authors: | Liu, H, Fang, Q, Cheng, L. | Deposit date: | 2018-05-12 | Release date: | 2018-07-04 | Last modified: | 2018-07-25 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6AVS
| Complex structure of JMJD5 and Symmetric Monomethyl-Arginine (MMA) | Descriptor: | (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, Lysine-specific demethylase 8, ZINC ION | Authors: | Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. | Deposit date: | 2017-09-04 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep, 8, 2018
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6AX3
| Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA) | Descriptor: | 2-OXOGLUTARIC ACID, Lysine-specific demethylase 8, N3, ... | Authors: | Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. | Deposit date: | 2017-09-06 | Release date: | 2018-02-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep, 8, 2018
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6L2L
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6L2M
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4UX5
| Structure of DNA complex of PCG2 | Descriptor: | 5'-D(*CP*AP*AP*TP*GP*AP*CP*GP*CP*GP*TP*AP*AP*GP)-3', 5'-D(*CP*TP*TP*AP*CP*GP*CP*GP*TP*CP*AP*TP*TP*GP)-3', TRANSCRIPTION FACTOR MBP1 | Authors: | Liu, J, Huang, J, Zhao, Y, Liu, H, Wang, D, Yang, J, Zhao, W, Taylor, I.A, Peng, Y. | Deposit date: | 2014-08-19 | Release date: | 2015-01-14 | Last modified: | 2015-02-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis of DNA Recognition by Pcg2 Reveals a Novel DNA Binding Mode for Winged Helix-Turn-Helix Domains. Nucleic Acids Res., 43, 2015
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1B10
| SOLUTION NMR STRUCTURE OF RECOMBINANT SYRIAN HAMSTER PRION PROTEIN RPRP(90-231) , 25 STRUCTURES | Descriptor: | PROTEIN (PRION PROTEIN) | Authors: | James, T.L, Liu, H, Ulyanov, N.B, Farr-Jones, S. | Deposit date: | 1998-11-25 | Release date: | 1998-12-02 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. Proc.Natl.Acad.Sci.USA, 94, 1997
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1AZV
| FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN) | Descriptor: | COPPER (II) ION, COPPER/ZINC SUPEROXIDE DISMUTASE, ZINC ION | Authors: | Hart, P.J, Liu, H, Pellegrini, M, Nersissian, A.M, Gralla, E.B, Valentine, J.S, Eisenberg, D. | Deposit date: | 1997-11-21 | Release date: | 1998-02-25 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis. Protein Sci., 7, 1998
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6XKQ
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-250 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CV07-250 Heavy Chain, CV07-250 Light Chain, ... | Authors: | Yuan, M, Liu, H, Zhu, X, Wu, N.C, Wilson, I.A. | Deposit date: | 2020-06-26 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model. Cell, 183, 2020
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6N5V
| Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine | Descriptor: | 2-(1H-indol-4-yl)ethan-1-amine, Strictosidine synthase | Authors: | Cai, Y, Shao, N, Xie, H, Futamura, Y, Panjikar, S, Liu, H, Zhu, H, Osada, H, Zou, H. | Deposit date: | 2018-11-22 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine to be published
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