1V16
| CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE | Descriptor: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, BENZAMIDINE, ... | Authors: | Li, J, Wynn, R.M, Machius, M, Chuang, J.L, Karthikeyan, S, Tomchick, D.R, Chuang, D.T. | Deposit date: | 2004-04-07 | Release date: | 2004-06-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase J.Biol.Chem., 279, 2004
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2O9Q
| The crystal structure of Bovine Trypsin complexed with a small inhibition peptide ORB2K | Descriptor: | CALCIUM ION, Cationic trypsin, ORB2K, ... | Authors: | Li, J, Zhang, C, Xu, X, Wang, J, Gong, W, Lai, R. | Deposit date: | 2006-12-14 | Release date: | 2007-12-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | From protease inhibitor to antibiotics: single point mutation makes tremendous functional shift To be Published
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2ESY
| Structure and influence on stability and activity of the N-terminal propetide part of lung surfactant protein C | Descriptor: | lung surfactant protein C | Authors: | Li, J, Liepinsh, E, Almlen, A, Thyberg, J, Curstedt, T, Jornvall, H, Johansson, J. | Deposit date: | 2005-10-27 | Release date: | 2005-11-15 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C Febs J., 273, 2006
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8CZP
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8EYX
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYY
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EZ0
| Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | Descriptor: | Insulin, Insulin receptor | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-29 | Release date: | 2022-11-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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8EYR
| Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-28 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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7BV3
| Crystal structure of a ugt transferase from Siraitia grosvenorii in complex with UDP | Descriptor: | Glycosyltransferase, URIDINE-5'-DIPHOSPHATE | Authors: | Li, J, Shan, N, Yang, J.G, Liu, W.D, Sun, Y.X. | Deposit date: | 2020-04-09 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases Green Synth Catal, 2021
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1YZX
| Crystal structure of human kappa class glutathione transferase | Descriptor: | Glutathione S-transferase kappa 1, L-GAMMA-GLUTAMYL-3-SULFINO-L-ALANYLGLYCINE | Authors: | Li, J, Xia, Z, Ding, J. | Deposit date: | 2005-02-28 | Release date: | 2005-11-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme PROTEIN SCI., 14, 2005
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3T10
| HSP90 N-terminal domain bound to ACP | Descriptor: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | Authors: | Li, J. | Deposit date: | 2011-07-21 | Release date: | 2012-01-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. Acta Biochim Biophys Sin (Shanghai), 44, 2012
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4Y5U
| Transcription factor | Descriptor: | NICKEL (II) ION, Signal transducer and activator of transcription 6 | Authors: | Li, J, Niu, F, Ouyang, S, Liu, Z. | Deposit date: | 2015-02-12 | Release date: | 2016-02-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.708 Å) | Cite: | Structural basis for DNA recognition by STAT6 Proc.Natl.Acad.Sci.USA, 113, 2016
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4Y5W
| Transcription factor-DNA complex | Descriptor: | DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), Signal transducer and activator of transcription 6 | Authors: | Li, J, Niu, F, Ouyang, S, Liu, Z. | Deposit date: | 2015-02-12 | Release date: | 2016-02-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.104 Å) | Cite: | Structural basis for DNA recognition by STAT6 Proc.Natl.Acad.Sci.USA, 113, 2016
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3T0H
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3T0Z
| Hsp90 N-terminal domain bound to ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | Authors: | Li, J. | Deposit date: | 2011-07-21 | Release date: | 2012-01-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.192 Å) | Cite: | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. Acta Biochim Biophys Sin (Shanghai), 44, 2012
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5D39
| Transcription factor-DNA complex | Descriptor: | DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*GP*GP*AP*AP*GP*AP*CP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*GP*TP*CP*TP*TP*CP*CP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), Signal transducer and activator of transcription 6 | Authors: | Li, J, Niu, F, Ouyang, S, Liu, Z. | Deposit date: | 2015-08-06 | Release date: | 2016-08-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for DNA recognition by STAT6 Proc.Natl.Acad.Sci.USA, 113, 2016
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1FBL
| STRUCTURE OF FULL-LENGTH PORCINE SYNOVIAL COLLAGENASE (MMP1) REVEALS A C-TERMINAL DOMAIN CONTAINING A CALCIUM-LINKED, FOUR-BLADED BETA-PROPELLER | Descriptor: | CALCIUM ION, FIBROBLAST (INTERSTITIAL) COLLAGENASE (MMP-1), N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE, ... | Authors: | Li, J, Brick, P, Blow, D.M. | Deposit date: | 1995-04-24 | Release date: | 1996-01-29 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller. Structure, 3, 1995
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1GXC
| FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide | Descriptor: | SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE | Authors: | Li, J, Williams, B.L, Haire, L.F, Goldberg, M, Wilker, E, Durocher, D, Yaffe, M.B, Jackson, S.P, Smerdon, S.J. | Deposit date: | 2002-04-02 | Release date: | 2002-06-13 | Last modified: | 2016-12-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2 Mol.Cell, 9, 2002
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8YCM
| Monomeric Human STK19 | Descriptor: | Isoform 4 of Inactive serine/threonine-protein kinase 19, SULFATE ION | Authors: | Li, J, Ma, X, Dong, Z. | Deposit date: | 2024-02-18 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Monomeric human STK19 To Be Published
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8W6I
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8W6J
| Cryo-EM structure of Escherichia coli Str K12 FtsE(E163Q)X/EnvC complex with ATP in peptidisc | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | Authors: | Li, J, Xu, X, He, Y, Luo, M. | Deposit date: | 2023-08-29 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of Escherichia coli Str K12 FtsE(E163Q)X/EnvC complex with ATP in peptidisc To Be Published
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8JIA
| Cryo-EM structure of Mycobacterium tuberculosis ATP bound FtsE(E165Q)X/RipC complex in peptidisc | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | Authors: | Li, J, Xu, X, Luo, M. | Deposit date: | 2023-05-26 | Release date: | 2023-10-04 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis. Nat Commun, 14, 2023
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8JQB
| Structure of Gabija GajA-GajB 4:4 Complex | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-06-13 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8JQC
| Novel Anti-phage System | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-06-13 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8JQ9
| Novel Anti-phage System | Descriptor: | Endonuclease GajA | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-06-13 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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