7EQ4
 
 | | Crystal Structure of the N-terminus of Nonstructural protein 1 from SARS-CoV-2 | | Descriptor: | Host translation inhibitor nsp1 | | Authors: | Liu, Y, Ke, Z, Hu, H, Zhao, K, Xiao, J, Xia, Y, Li, Y. | | Deposit date: | 2021-04-29 | | Release date: | 2021-06-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1.
Microbiol Spectr, 9, 2021
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5B73
 | | Crystal structure of human ZMYND8 PHD-Bromo-PWWP domain | | Descriptor: | Protein kinase C-binding protein 1, ZINC ION | | Authors: | Li, H, Li, Y, Zheng, X. | | Deposit date: | 2016-06-03 | | Release date: | 2016-11-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes
Mol.Cell, 63, 2016
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4I52
 | | scMenB im complex with 1-hydroxy-2-naphthoyl-CoA | | Descriptor: | 1-hydroxy-2-naphthoyl-CoA, CHLORIDE ION, Naphthoate synthase | | Authors: | Song, H.G, Sun, Y.R, Li, J, Li, Y, Jiang, M, Zhou, J.H, Guo, Z.H. | | Deposit date: | 2012-11-28 | | Release date: | 2013-05-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme a synthase from the crotonase fold superfamily
Plos One, 8, 2013
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4I4Z
 | | Synechocystis sp. PCC 6803 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in complex with salicylyl-CoA | | Descriptor: | BICARBONATE ION, MALONATE ION, Naphthoate synthase, ... | | Authors: | Song, H.G, Sun, Y.R, Li, J, Li, Y, Jiang, M, Zhou, J.H, Guo, Z.H. | | Deposit date: | 2012-11-28 | | Release date: | 2013-05-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme a synthase from the crotonase fold superfamily
Plos One, 8, 2013
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8BFN
 | | E. coli Wadjet JetABC dimer of dimers | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | | Authors: | Roisne-Hamelin, F, Beckert, B, Myasnikov, A, Li, Y, Gruber, S. | | Deposit date: | 2022-10-26 | | Release date: | 2022-12-14 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage.
Mol.Cell, 82, 2022
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8BS6
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3O19
 | | Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid | | Descriptor: | OLEIC ACID, PALMITIC ACID, Prostaglandin-H2 D-isomerase | | Authors: | Zhou, Y, Shaw, N, Li, Y, Zhao, Y, Zhang, R, Liu, Z.-J. | | Deposit date: | 2010-07-21 | | Release date: | 2010-09-22 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid
To be Published
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3O2Y
 | | Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid | | Descriptor: | GLYCEROL, OLEIC ACID, PALMITIC ACID, ... | | Authors: | Zhou, Y, Shaw, N, Li, Y, Zhao, Y, Zhang, R, Liu, Z.-J. | | Deposit date: | 2010-07-23 | | Release date: | 2010-09-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid
To be Published
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3O22
 | | Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid | | Descriptor: | OLEIC ACID, PALMITIC ACID, Prostaglandin-H2 D-isomerase | | Authors: | Zhou, Y, Shaw, N, Li, Y, Zhao, Y, Zhang, R, Liu, Z.-J. | | Deposit date: | 2010-07-22 | | Release date: | 2010-09-22 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid
To be Published
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8DYS
 | | Crystal structure of human Eukaryotic translation initiation factor 2A (eIF2A) | | Descriptor: | 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 2A, GLYCEROL, ... | | Authors: | Righetto, G.L, Zeng, H, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-08-05 | | Release date: | 2022-08-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of human Eukaryotic translation initiation factor 2A (eIF2A)
To Be Published
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8DYO
 | | Cryo-EM structure of Importin-4 bound to RanGTP | | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... | | Authors: | Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. | | Deposit date: | 2022-08-04 | | Release date: | 2022-09-21 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (7.1 Å) | | Cite: | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8EQZ
 | | Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog T0-C6 | | Descriptor: | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-hexylbenzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 | | Authors: | Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Lin, W, Li, Y, Chen, T. | | Deposit date: | 2022-10-11 | | Release date: | 2023-03-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
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3PFN
 | | Crystal Structure of human NAD kinase | | Descriptor: | NAD kinase, UNKNOWN ATOM OR ION | | Authors: | Wang, H, Tempel, W, Wernimont, A.K, Tong, Y, Guan, X, Shen, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-10-28 | | Release date: | 2010-11-10 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structure of human NAD kinase
to be published
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4DQM
 | | Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity | | Descriptor: | (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, Nuclear receptor coactivator 1, Retinoic acid receptor alpha | | Authors: | Wang, S, Wang, Z, Lin, S, Zheng, W, Wang, R, Jin, S, Chen, J, Jin, L, Li, Y. | | Deposit date: | 2012-02-16 | | Release date: | 2012-10-03 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.
Biochem.J., 446, 2012
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1T0F
 | | Crystal Structure of the TnsA/TnsC(504-555) complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, MALONIC ACID, ... | | Authors: | Ronning, D.R, Li, Y, Perez, Z.N, Ross, P.D, Hickman, A.B, Craig, N.L, Dyda, F. | | Deposit date: | 2004-04-08 | | Release date: | 2004-11-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA.
Embo J., 23, 2004
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2FMX
 | | An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+) | | Descriptor: | GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Rao, Y, Bian, C, Yuan, C, Li, Y, Huang, M. | | Deposit date: | 2006-01-10 | | Release date: | 2006-09-05 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)
Biochem.Biophys.Res.Commun., 348, 2006
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2G1K
 | | Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimate at 1.75 angstrom resolution | | Descriptor: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, CHLORIDE ION, SULFATE ION, ... | | Authors: | Gan, J, Gu, Y, Li, Y, Yan, H, Ji, X. | | Deposit date: | 2006-02-14 | | Release date: | 2006-07-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal Structure of Mycobacterium tuberculosis Shikimate Kinase in Complex with Shikimic Acid and an ATP Analogue.
Biochemistry, 45, 2006
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2G1J
 | | Crystal structure of Mycobacterium tuberculosis Shikimate Kinase at 2.0 angstrom resolution | | Descriptor: | SULFATE ION, Shikimate kinase | | Authors: | Gan, J, Gu, Y, Li, Y, Yan, H, Ji, X. | | Deposit date: | 2006-02-14 | | Release date: | 2006-07-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Mycobacterium tuberculosis Shikimate Kinase in Complex with Shikimic Acid and an ATP Analogue.
Biochemistry, 45, 2006
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7UFV
 | | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-6766 | | Descriptor: | (3P)-N-[(1S)-3-amino-1-(3-chlorophenyl)-3-oxopropyl]-3-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, DDB1- and CUL4-associated factor 1, UNKNOWN ATOM OR ION | | Authors: | Kimani, S, Li, A, Li, Y, Dong, A, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-03-23 | | Release date: | 2022-05-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Discovery of Nanomolar DCAF1 Small Molecule Ligands.
J.Med.Chem., 66, 2023
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1IJI
 | | Crystal Structure of L-Histidinol Phosphate Aminotransferase with PLP | | Descriptor: | Histidinol Phosphate Aminotransferase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Sivaraman, J, Li, Y, Larocque, R, Schrag, J.D, Cygler, M, Matte, A. | | Deposit date: | 2001-04-26 | | Release date: | 2001-08-29 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate.
J.Mol.Biol., 311, 2001
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3I3C
 | | Crystal Structural of CBX5 Chromo Shadow Domain | | Descriptor: | Chromobox protein homolog 5, SODIUM ION | | Authors: | Amaya, M.F, Li, Z, Li, Y, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-06-30 | | Release date: | 2009-08-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Crystal Structural of CBX5 Chromo Shadow Domain
To be Published
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1JHN
 | | Crystal Structure of the Lumenal Domain of Calnexin | | Descriptor: | CALCIUM ION, calnexin | | Authors: | Schrag, J.D, Bergeron, J.M, Li, Y, Borisova, S, Hahn, M, Thomas, D.Y, Cygler, M. | | Deposit date: | 2001-06-28 | | Release date: | 2001-10-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The Structure of calnexin, an ER chaperone involved in quality control of protein folding.
Mol.Cell, 8, 2001
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1JA3
 | | Crystal Structure of the Murine NK Cell Inhibitory Receptor Ly-49I | | Descriptor: | MHC class I recognition receptor Ly49I | | Authors: | Dimasi, N, Sawicki, W.M, Reineck, L.A, Li, Y, Natarajan, K, Murgulies, D.H, Mariuzza, A.R. | | Deposit date: | 2001-05-29 | | Release date: | 2002-07-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.
J.Mol.Biol., 320, 2002
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1KAR
 | | L-HISTIDINOL DEHYDROGENASE (HISD) STRUCTURE COMPLEXED WITH HISTAMINE (INHIBITOR), ZINC AND NAD (COFACTOR) | | Descriptor: | HISTAMINE, Histidinol dehydrogenase, ZINC ION | | Authors: | Barbosa, J.A.R.G, Sivaraman, J, Li, Y, Larocque, R, Matte, A, Schrag, J.D, Cygler, M. | | Deposit date: | 2001-11-02 | | Release date: | 2002-06-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1K6M
 | | Crystal Structure of Human Liver 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase | | Descriptor: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2-phosphatase, PHOSPHATE ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Lee, Y.H, Li, Y, Uyeda, K, Hasemann, C.A. | | Deposit date: | 2001-10-16 | | Release date: | 2002-12-11 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
J.Biol.Chem., 278, 2003
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