3P8Z
 
 | | Dengue Methyltransferase bound to a SAM-based inhibitor | | Descriptor: | (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, Non-structural protein 5, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Noble, C.G, Yap, L.J, Lescar, J. | | Deposit date: | 2010-10-15 | | Release date: | 2010-12-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
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3OV9
 | | Structure of the Nucleoprotein from Rift Valley Fever Virus | | Descriptor: | NITRITE ION, Nucleoprotein, SODIUM ION | | Authors: | Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J. | | Deposit date: | 2010-09-16 | | Release date: | 2011-05-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
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3P97
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3OUO
 | | Structure of the Nucleoprotein from Rift Valley Fever Virus | | Descriptor: | NITRITE ION, Nucleoprotein | | Authors: | Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J. | | Deposit date: | 2010-09-15 | | Release date: | 2011-05-25 | | Last modified: | 2013-08-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
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1KDH
 | | Binary Complex of Murine Terminal Deoxynucleotidyl Transferase with a Primer Single Stranded DNA | | Descriptor: | 5'-D(P*(BRU)P*(BRU)P*(BRU)P*(BRU))-3', MAGNESIUM ION, SODIUM ION, ... | | Authors: | Delarue, M, Boule, J.B, Lescar, J, Expert-Bezancon, N, Jourdan, N, Sukumar, N, Rougeon, F, Papanicolaou, C. | | Deposit date: | 2001-11-13 | | Release date: | 2002-05-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.
EMBO J., 21, 2002
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1KEJ
 | | Crystal Structure of Murine Terminal Deoxynucleotidyl Transferase complexed with ddATP | | Descriptor: | 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, COBALT (II) ION, SODIUM ION, ... | | Authors: | Delarue, M, Boule, J.B, Lescar, J, Expert-Bezancon, N, Jourdan, N, Sukumar, N, Rougeon, F, Papanicolaou, C. | | Deposit date: | 2001-11-16 | | Release date: | 2002-05-16 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.
EMBO J., 21, 2002
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4BFH
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3SY8
 | | Crystal structure of the response regulator RocR | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, RocR | | Authors: | Chen, M.W, Kotaka, M, Vonrhein, C, Bricogne, G, Lescar, J. | | Deposit date: | 2011-07-16 | | Release date: | 2012-07-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling.
J.Bacteriol., 194, 2012
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6KSH
 | | Crystal structure of pyruvate kinase (PYK) from Plasmodium falciparum in complex with oxalate and ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, OXALATE ION, ... | | Authors: | Zhong, W, Cai, Q, Li, K, Lescar, J, Dedon, P.C. | | Deposit date: | 2019-08-23 | | Release date: | 2020-08-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.
Biochem.Biophys.Res.Commun., 532, 2020
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2GEC
 | | Structure of the N-terminal domain of avian infectious bronchitis virus nucleocapsid protein (strain Gray) in a novel dimeric arrangement | | Descriptor: | Nucleocapsid protein | | Authors: | Jayaram, H, Fan, H, Bowman, B.R, Ooi, A, Jayaram, J, Collisson, E.W, Lescar, J, Prasad, B.V. | | Deposit date: | 2006-03-19 | | Release date: | 2006-06-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation.
J.Virol., 80, 2006
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2P28
 | | Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2 | | Authors: | Shi, M, Foo, S.Y, Tan, S.M, Mitchell, E.P, Law, S.K.A, Lescar, J. | | Deposit date: | 2007-03-07 | | Release date: | 2007-08-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins
J.Biol.Chem., 282, 2007
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2CCV
 | | Structure of Helix Pomatia agglutinin with zinc and N-acetyl-alpha-D- galactoseamine (GalNAc) | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Sanchez, J.-F, Lescar, J, Chazalet, V, Audfray, A, Gautier, C, Gagnon, J, Breton, C, Imberty, A, Mitchell, E.P. | | Deposit date: | 2006-01-18 | | Release date: | 2006-05-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Biochemical and Structural Analysis of Helix Pomatia Agglutinin. A Hexameric Lectin with a Novel Fold.
J.Biol.Chem., 281, 2006
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2CA1
 | | Crystal structure of the IBV coronavirus nucleocapsid | | Descriptor: | NUCLEOCAPSID PROTEIN | | Authors: | Jayaram, H, Fan, H, Bowman, B.R, Ooi, A, Jayaram, J, Collison, E.W, Lescar, J, Prasad, B.V.V. | | Deposit date: | 2005-12-16 | | Release date: | 2006-06-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation.
J.Virol., 80, 2006
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2C86
 | | x-ray structure of the N and C-terminal domain of coronavirus nucleocapsid protein. | | Descriptor: | NUCLEOCAPSID PROTEIN | | Authors: | Jayaram, H, Fan, H, Bowman, B.R, Ooi, A, Jayaram, J, Collinson, E.W, Lescar, J, Prasad, B.V.V. | | Deposit date: | 2005-12-02 | | Release date: | 2006-06-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation.
J.Virol., 80, 2006
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2CE6
 | | Structure of Helix Pomatia agglutinin with no ligands | | Descriptor: | HELIX POMATIA AGGLUTININ | | Authors: | Sanchez, J.-F, Lescar, J, Chazalet, V, Audfray, A, Gautier, C, Gagnon, J, Breton, C, Imberty, A, Mitchell, E.P. | | Deposit date: | 2006-02-03 | | Release date: | 2006-05-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Biochemical and Structural Analysis of Helix Pomatia Agglutinin. A Hexameric Lectin with a Novel Fold.
J.Biol.Chem., 281, 2006
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2VBC
 | | Crystal structure of the NS3 protease-helicase from Dengue virus | | Descriptor: | DENGUE 4 NS3 FULL-LENGTH PROTEIN, PARTIAL POLYPROTEIN FOR NS2A AND NS2B, TYPE 4 PROTOTYPE DV4 H241 | | Authors: | Luo, D.H, Xu, T, Hunke, C, Gruber, G, Vasudevan, S.G, Lescar, J. | | Deposit date: | 2007-09-10 | | Release date: | 2007-10-30 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Crystal Structure of the Ns3 Protease-Helicase from Dengue Virus.
J.Virol., 82, 2008
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2VN1
 | | Crystal structure of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with FK506 | | Descriptor: | 70 KDA PEPTIDYLPROLYL ISOMERASE, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | | Authors: | Kotaka, M, Alag, R, Ye, H, Preiser, P.R, Yoon, H.S, Lescar, J. | | Deposit date: | 2008-01-30 | | Release date: | 2008-05-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal Structure of the Fk506 Binding Domain of Plasmodium Falciparum Fkbp35 in Complex with Fk506.
Biochemistry, 47, 2008
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2W3X
 | | Crystal structure of a bifunctional hotdog fold thioesterase in enediyne biosynthesis, CalE7 | | Descriptor: | CALE7, GLYCEROL, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), ... | | Authors: | Kotaka, M, Kong, R, Qureshi, I, Ho, Q.S, Sun, H, Liew, C.W, Goh, L.P, Cheung, P, Mu, Y, Lescar, J, Liang, Z.X. | | Deposit date: | 2008-11-17 | | Release date: | 2009-04-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure and Catalytic Mechanism of the Thioesterase Cale7 in Enediyne Biosynthesis.
J.Biol.Chem., 284, 2009
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2GE8
 | | Structure of the C-terminal dimerization domain of infectious bronchitis virus nucleocapsid protein | | Descriptor: | Nucleocapsid protein | | Authors: | Jayaram, H, Fan, H, Bowman, B.R, Ooi, A, Jayaram, J, Collisson, E.W, Lescar, J, Prasad, B.V. | | Deposit date: | 2006-03-18 | | Release date: | 2006-06-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation.
J.Virol., 80, 2006
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2GE7
 | | Structure of the C-terminal dimerization domain of infectious bronchitis virus nucleocapsid protein | | Descriptor: | Nucleocapsid protein | | Authors: | Jayaram, H, Fan, H, Bowman, B.R, Ooi, A, Jayaram, J, Collisson, E.W, Lescar, J, Prasad, B.V. | | Deposit date: | 2006-03-18 | | Release date: | 2006-06-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation.
J.Virol., 80, 2006
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5FSW
 | | RNA dependent RNA polymerase QDE-1 from Thielavia terrestris | | Descriptor: | RNA DEPENDENT RNA POLYMERASE QDE-1 | | Authors: | Qian, X, Hamid, F.M, El Sahili, A, Darwis, D.A, Wong, Y.H, Bhushan, S, Makeyev, E.V, Lescar, J. | | Deposit date: | 2016-01-08 | | Release date: | 2016-03-02 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Functional Evolution in Orthologous Cell-Encoded RNA-Dependent RNA Polymerases
J.Biol.Chem., 291, 2016
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3VWS
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107 | | Descriptor: | 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, Non-structural protein 5, ... | | Authors: | Noble, C.G, Lescar, J. | | Deposit date: | 2012-08-31 | | Release date: | 2013-02-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor
J.Virol., 87, 2013
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2JLV
 | | Dengue virus 4 NS3 helicase in complex with ssRNA and AMPPNP | | Descriptor: | 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', CHLORIDE ION, GLYCEROL, ... | | Authors: | Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. | | Deposit date: | 2008-09-15 | | Release date: | 2008-11-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein
Embo J., 27, 2008
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2JLW
 | | Dengue virus 4 NS3 helicase in complex with ssRNA2 | | Descriptor: | 5'-R(*UP*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', GLYCEROL, PHOSPHATE ION, ... | | Authors: | Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. | | Deposit date: | 2008-09-15 | | Release date: | 2008-11-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein
Embo J., 27, 2008
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2JLQ
 | | Dengue virus 4 NS3 helicase structure, apo enzyme. | | Descriptor: | CHLORIDE ION, GLYCEROL, SERINE PROTEASE SUBUNIT NS3 | | Authors: | Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. | | Deposit date: | 2008-09-15 | | Release date: | 2008-11-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
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