5AMD
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6TL6
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6TL5
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6QUT
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6QN2
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6QN6
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6QN5
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6FE0
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6FE2
| Three dimensional structure of human carbonic anhydrase IX | Descriptor: | Carbonic anhydrase 9, ZINC ION | Authors: | Leitans, J, Tars, K. | Deposit date: | 2017-12-28 | Release date: | 2018-07-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget, 9, 2018
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6FE1
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6G98
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6G9U
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4BF6
| Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide | Descriptor: | 5-[1-(3-cyanophenyl)-1,2,3-triazol-4-yl]thiophene-2-sulfonamide, CARBONIC ANHYDRASE 2, GLYCEROL, ... | Authors: | Tars, K, Leitans, J, Zalubovskis, R. | Deposit date: | 2013-03-15 | Release date: | 2014-01-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | 5-Substituted-(1,2,3-Triazol-4-Yl)Thiophene-2-Sulfonamides Strongly Inhibit Human Carbonic Anhydrases I, II, Ix and Xii: Solution and X-Ray Crystallographic Studies. Bioorg.Med.Chem., 21, 2013
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4BF1
| Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide | Descriptor: | 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide, CARBONIC ANHYDRASE 2, SODIUM ION, ... | Authors: | Tars, K, Leitans, J, Zalubovskis, R. | Deposit date: | 2013-03-13 | Release date: | 2014-01-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | 5-Substituted-(1,2,3-Triazol-4-Yl)Thiophene-2-Sulfonamides Strongly Inhibit Human Carbonic Anhydrases I, II, Ix and Xii: Solution and X-Ray Crystallographic Studies. Bioorg.Med.Chem., 21, 2013
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5MJN
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4V6K
| Structural insights into cognate vs. near-cognate discrimination during decoding. | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Agirrezabala, X, Schreiner, E, Trabuco, L.G, Lei, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J. | Deposit date: | 2011-01-07 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (8.25 Å) | Cite: | Structural insights into cognate versus near-cognate discrimination during decoding. Embo J., 30, 2011
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4V6L
| Structural insights into cognate vs. near-cognate discrimination during decoding. | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Agirrezabala, X, Schreiner, E, Trabuco, L.G, Lei, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J. | Deposit date: | 2011-01-07 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (13.2 Å) | Cite: | Structural insights into cognate versus near-cognate discrimination during decoding. Embo J., 30, 2011
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5XJC
| Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y. | Deposit date: | 2017-04-30 | Release date: | 2017-07-05 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | An Atomic Structure of the Human Spliceosome Cell, 169, 2017
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6IDF
| Cryo-EM structure of gamma secretase in complex with a Notch fragment | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y. | Deposit date: | 2018-09-09 | Release date: | 2018-12-26 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis of Notch recognition by human gamma-secretase Nature, 565, 2019
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4WTR
| Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaribiose | Descriptor: | beta-1,3-glucanosyltransferase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | Authors: | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | Deposit date: | 2014-10-30 | Release date: | 2015-08-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
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4WTP
| Crystal structure of glycoside hydrolase family 17 beta-1,3-glucanosyltransferase from Rhizomucor miehei | Descriptor: | 1,2-ETHANEDIOL, beta-1,3-glucanosyltransferase | Authors: | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | Deposit date: | 2014-10-30 | Release date: | 2015-08-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
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4WTS
| Active-site mutant of Rhizomucor miehei beta-1,3-glucanosyltransferase in complex with laminaritriose | Descriptor: | beta-1,3-glucanosyltransferase, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | Authors: | Qin, Z, Yan, Q, Lei, J, Yang, S, Jiang, Z. | Deposit date: | 2014-10-30 | Release date: | 2015-08-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D, 71, 2015
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7OXG
| ttSlyD FKBP domain with M8A pseudo-wild-type S2 peptide | Descriptor: | 30S ribosomal protein S2, CHLORIDE ION, IMIDAZOLE, ... | Authors: | Pazicky, S, Lei, J, Loew, C. | Deposit date: | 2021-06-22 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Impact of distant peptide substrate residues on enzymatic activity of SlyD. Cell.Mol.Life Sci., 79, 2022
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7OXI
| ttSlyD with W4A pseudo-wild-type S2 peptide | Descriptor: | 30S ribosomal protein S2, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase | Authors: | Pazicky, S, Lei, J, Loew, C. | Deposit date: | 2021-06-22 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Impact of distant peptide substrate residues on enzymatic activity of SlyD. Cell.Mol.Life Sci., 79, 2022
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7OXK
| ttSlyD with W4K pseudo-wild-type S2 peptide | Descriptor: | 30S ribosomal protein S2, Peptidyl-prolyl cis-trans isomerase | Authors: | Pazicky, S, Lei, J, Loew, C. | Deposit date: | 2021-06-22 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Impact of distant peptide substrate residues on enzymatic activity of SlyD. Cell.Mol.Life Sci., 79, 2022
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