3KLS
 
 | | Structure of complement C5 in complex with SSL7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | | 著者 | Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R. | | 登録日 | 2009-11-09 | | 公開日 | 2009-11-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
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3KM9
 | | Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | | 著者 | Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R. | | 登録日 | 2009-11-10 | | 公開日 | 2009-12-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
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3PRX
 | | Structure of Complement C5 in Complex with CVF and SSL7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ... | | 著者 | Laursen, N.S, Andersen, G.R, Sottrup-Jensen, L, Andersen, K.R, Spillner, E, Braren, I. | | 登録日 | 2010-11-30 | | 公開日 | 2011-01-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
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3PVM
 | | Structure of Complement C5 in Complex with CVF | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, Complement C5 | | 著者 | Laursen, N.S, Andersen, K.R, Braren, I, Sottrup-Jensen, L, Spillner, E, Andersen, G.R. | | 登録日 | 2010-12-07 | | 公開日 | 2011-01-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
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6Z6V
 | | Globular head of C1q in complex with the nanobody C1qNb75 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, ... | | 著者 | Laursen, N.S, Andersen, G.R. | | 登録日 | 2020-05-29 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.
Front Immunol, 11, 2020
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6FYT
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6FYW
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6FYU
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6FYS
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5NQW
 | | IgE-Fc in complex with single domain antibody 026 | | 分子名称: | 026, GLYCEROL, Immunoglobulin heavy constant epsilon, ... | | 著者 | Laursen, N.S, Jabs, F, Spillner, E, Andersen, G.R. | | 登録日 | 2017-04-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc epsilon RI interaction.
Nat Commun, 9, 2018
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5NLU
 | | Structure of Nb36 crystal form 1 | | 分子名称: | SULFATE ION, single domain llama antibody Nb36 | | 著者 | Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R. | | 登録日 | 2017-04-05 | | 公開日 | 2017-05-31 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.193 Å) | | 主引用文献 | Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
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6YSQ
 | | The hC4Nb8 complement inhibitory nanobody in complex with C4b | | 分子名称: | Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ... | | 著者 | Zarantonello, A, Laursen, N.S, Andersen, G.R. | | 登録日 | 2020-04-23 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
J Immunol., 205, 2020
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5NLW
 | | Structure of Nb36 crystal form 2 | | 分子名称: | SULFATE ION, nanobody Nb36 | | 著者 | Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R. | | 登録日 | 2017-04-05 | | 公開日 | 2017-05-31 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
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5NM0
 | | Nb36 Ser85Cys with Hg, crystal form 1 | | 分子名称: | MERCURY (II) ION, Nb36 | | 著者 | Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R. | | 登録日 | 2017-04-05 | | 公開日 | 2017-06-07 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
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5NML
 | | Nb36 Ser85Cys with Hg bound | | 分子名称: | 1,2-ETHANEDIOL, MERCURY (II) ION, Nanobody Nb36 Ser85Cys | | 著者 | Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R. | | 登録日 | 2017-04-06 | | 公開日 | 2017-06-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
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6QUP
 | | Structural signatures in EPR3 define a unique class of plant carbohydrate receptors | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ISOPROPYL ALCOHOL, ... | | 著者 | Wong, J.E, Gysel, K, Birkefeldt, T.G, Vinther, M, Muszynski, A, Azadi, P, Laursen, N.S, Sullivan, J.T, Ronson, C.W, Stougaard, J, Andersen, K.R. | | 登録日 | 2019-02-28 | | 公開日 | 2020-08-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.871 Å) | | 主引用文献 | Structural signatures in EPR3 define a unique class of plant carbohydrate receptors.
Nat Commun, 11, 2020
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6RU3
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4FQM
 | | Structure of B/Brisbane/60/2008 Influenza Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... | | 著者 | Dreyfus, C, Laursen, N.S, Wilson, I.A. | | 登録日 | 2012-06-25 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
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4FQL
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4FQK
 | | Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8059 Heavy Chain, ... | | 著者 | Dreyfus, C, Laursen, N.S, Wilson, I.A. | | 登録日 | 2012-06-25 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (5.65 Å) | | 主引用文献 | Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
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4FQJ
 | | Influenza B/Florida/4/2006 hemagglutinin Fab CR8071 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, antibody CR8071 heavy chain, ... | | 著者 | Dreyfus, C, Laursen, N.S, Wilson, I.A. | | 登録日 | 2012-06-25 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
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6EHG
 | | complement component C3b in complex with a nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R. | | 登録日 | 2017-09-13 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293, 2018
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6CNW
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6CK8
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6CNV
 | | INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 Fab heavy chain, ... | | 著者 | Luo, J, Obmolova, G. | | 登録日 | 2018-03-09 | | 公開日 | 2018-11-14 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
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