5NQW

IgE-Fc in complex with single domain antibody 026

Summary for 5NQW

• Entry DOI: 10.2210/pdb5nqw/pdb
• Descriptor: Immunoglobulin heavy constant epsilon, 026, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: ige-fc, nanobody, vhh, allergy, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 79828.77

Authors

Laursen, N.S.,Jabs, F.,Spillner, E.,Andersen, G.R. (deposition date: 2017-04-21, release date: 2018-01-17, Last modification date: 2024-01-17)

• Primary citation: Jabs, F.,Plum, M.,Laursen, N.S.,Jensen, R.K.,Molgaard, B.,Miehe, M.,Mandolesi, M.,Rauber, M.M.,Pfutzner, W.,Jakob, T.,Mobs, C.,Andersen, G.R.,Spillner, E.; Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc epsilon RI interaction.; Nat Commun, 9:7-7, 2018; PubMed: 29295972; DOI: 10.1038/s41467-017-02312-7

Experimental method

X-RAY DIFFRACTION (3.4 Å)