3GFK
 
 | | Crystal structure of Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex | | 分子名称: | DNA-directed RNA polymerase subunit alpha, Regulatory protein spx | | 著者 | Lamour, V, Westblade, L.F, Campbell, E.A, Darst, S.A. | | 登録日 | 2009-02-27 | | 公開日 | 2009-03-10 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex
J.Struct.Biol., 168, 2009
|
|
2ETN
 | | Crystal structure of Thermus aquaticus Gfh1 | | 分子名称: | anti-cleavage anti-GreA transcription factor Gfh1 | | 著者 | Lamour, V, Hogan, B.P, Erie, D.A, Darst, S.A. | | 登録日 | 2005-10-27 | | 公開日 | 2006-02-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage.
J.Mol.Biol., 356, 2006
|
|
1KIJ
 | | Crystal structure of the 43K ATPase domain of Thermus thermophilus gyrase B in complex with novobiocin | | 分子名称: | DNA GYRASE SUBUNIT B, FORMIC ACID, NOVOBIOCIN | | 著者 | Lamour, V, Hoermann, L, Jeltsch, J.-M, Oudet, P, Moras, D. | | 登録日 | 2001-12-03 | | 公開日 | 2002-06-03 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | An open conformation of the Thermus thermophilus gyrase B ATP-binding domain.
J.Biol.Chem., 277, 2002
|
|
3BMB
 | |
2GHO
 | |
1US0
 | | Human Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom | | 分子名称: | ALDOSE REDUCTASE, CITRIC ACID, IDD594, ... | | 著者 | Howard, E.I, Sanishvili, R, Cachau, R.E, Mitschler, A, Chevrier, B, Barth, P, Lamour, V, Van Zandt, M, Sibley, E, Bon, C, Moras, D, Schneider, T.R, Joachimiak, A, Podjarny, A. | | 登録日 | 2003-11-16 | | 公開日 | 2004-05-07 | | 最終更新日 | 2019-05-22 | | 実験手法 | X-RAY DIFFRACTION (0.66 Å) | | 主引用文献 | Ultrahigh Resolution Drug Design I: Details of Interactions in Human Aldose Reductase-Inhibitor Complex at 0.66 A.
Proteins, 55, 2004
|
|
1PFJ
 | | Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit | | 分子名称: | TFIIH basal transcription factor complex p62 subunit | | 著者 | Gervais, V, Lamour, V, Jawhari, A, Frindel, F, Wasielewski, E, Thierry, J.C, Kieffer, B, Poterszman, A, Structural Proteomics in Europe (SPINE) | | 登録日 | 2003-05-27 | | 公開日 | 2004-06-08 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | TFIIH contains a PH domain involved in DNA nucleotide excision repair.
Nat.Struct.Mol.Biol., 11, 2004
|
|
8QDX
 | |
8QQU
 | |
8QQS
 | |
8A43
 | | Human RNA polymerase I | | 分子名称: | DNA-directed RNA polymerase I subunit RPA1, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA2, ... | | 著者 | Daiss, J.L, Pilsl, M, Straub, K, Bleckmann, A, Hoecherl, M, Heiss, F.B, Abascal-Palacios, G, Ramsay, E, Tluckova, K, Mars, J.C, Fuertges, T, Bruckmann, A, Rudack, T, Bernecky, C, Lamour, V, Panov, K, Vannini, A, Moss, T, Engel, C. | | 登録日 | 2022-06-10 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-11-02 | | 実験手法 | ELECTRON MICROSCOPY (4.09 Å) | | 主引用文献 | The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.
Life Sci Alliance, 5, 2022
|
|
2P7V
 | | Crystal structure of the Escherichia coli regulator of sigma 70, Rsd, in complex with sigma 70 domain 4 | | 分子名称: | MAGNESIUM ION, RNA polymerase sigma factor rpoD, Regulator of sigma D | | 著者 | Patikoglou, G.A, Westblade, L.F, Campbell, E.A, Lamour, V, Lane, W.J, Darst, S.A. | | 登録日 | 2007-03-20 | | 公開日 | 2007-08-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4.
J.Mol.Biol., 372, 2007
|
|
3D36
 | | How to Switch Off a Histidine Kinase: Crystal Structure of Geobacillus stearothermophilus KinB with the Inhibitor Sda | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Bick, M.J, Lamour, V, Rajashankar, K.R, Gordiyenko, Y, Robinson, C.V, Darst, S.A. | | 登録日 | 2008-05-09 | | 公開日 | 2009-01-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda
J.Mol.Biol., 386, 2009
|
|
6ENH
 | |
6ENG
 | | Crystal structure of the 43K ATPase domain of Escherichia coli gyrase B in complex with an aminocoumarin | | 分子名称: | CHLORIDE ION, Coumermycin A1, DNA gyrase subunit B, ... | | 著者 | Vanden Broeck, A, McEwen, A.G, Lamour, V. | | 登録日 | 2017-10-04 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis for DNA Gyrase Interaction with Coumermycin A1.
J.Med.Chem., 62, 2019
|
|
6ZY7
 | | Cryo-EM structure of the entire Human topoisomerase II alpha in State 1 | | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2020-07-30 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (4.64 Å) | | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
|
|
6ZY6
 | | Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2 | | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2020-07-30 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
|
|
6ZY8
 | | Cryo-EM structure of the entire Human topoisomerase II alpha in State 2 | | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2020-07-30 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
|
|
6ZY5
 | | Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1 | | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2020-07-30 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-06-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
|
|
6RKW
 | | CryoEM structure of the complete E. coli DNA Gyrase complex bound to a 130 bp DNA duplex | | 分子名称: | (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (58-MER), DNA (62-MER), ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2019-04-30 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-11-18 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
|
|
6RKS
 | | E. coli DNA Gyrase - DNA binding and cleavage domain in State 1 without TOPRIM insertion | | 分子名称: | (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA Strand 1, DNA Strand 2, ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2019-04-30 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-11-18 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
|
|
6RKV
 | |
6RKU
 | | E. coli DNA Gyrase - DNA binding and cleavage domain in State 1 | | 分子名称: | (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA Strand 1, DNA Strand 2, ... | | 著者 | Vanden Broeck, A, Lamour, V. | | 登録日 | 2019-04-30 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-11-18 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
|
|
1KZN
 | | Crystal Structure of E. coli 24kDa Domain in Complex with Clorobiocin | | 分子名称: | CLOROBIOCIN, DNA GYRASE SUBUNIT B | | 著者 | Lafitte, D, Lamour, V, Tsvetkov, P.O, Makarov, A.A, Klich, M, Deprez, P, Moras, D, Briand, C, Gilli, R. | | 登録日 | 2002-02-07 | | 公開日 | 2002-06-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.
Biochemistry, 41, 2002
|
|
1EKO
 | | PIG ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR | | 分子名称: | ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE | | 著者 | Podjarny, A. | | 登録日 | 2000-03-09 | | 公開日 | 2000-05-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The structure of human aldose reductase bound to the inhibitor IDD384.
Acta Crystallogr.,Sect.D, 56, 2000
|
|
