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8IG1
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BU of 8ig1 by Molmil
Crystal structure of wild-type transthyretin in complex with rafoxanide
Descriptor: SODIUM ION, Transthyretin, ~{N}-[3-chloranyl-4-(4-chloranylphenoxy)phenyl]-3,5-bis(iodanyl)-2-oxidanyl-benzamide
Authors:Yokoyama, T.
Deposit date:2023-02-20
Release date:2023-08-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin.
Febs J., 290, 2023
8IE6
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BU of 8ie6 by Molmil
Crystal structure of DAPK1 in complex with pinostilbene
Descriptor: 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, Death-associated protein kinase 1, SULFATE ION
Authors:Yokoyama, T.
Deposit date:2023-02-15
Release date:2023-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Characterization of the molecular interactions between resveratrol derivatives and death-associated protein kinase 1.
Febs J., 290, 2023
8IE5
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BU of 8ie5 by Molmil
Crystal structure of DAPK1 in complex with oxyresveratrol
Descriptor: Death-associated protein kinase 1, SULFATE ION, trans-oxyresveratrol
Authors:Yokoyama, T.
Deposit date:2023-02-15
Release date:2023-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Characterization of the molecular interactions between resveratrol derivatives and death-associated protein kinase 1.
Febs J., 290, 2023
8IE8
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BU of 8ie8 by Molmil
Crystal structure of DAPK1 in complex with isorhapontigenin
Descriptor: 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, Death-associated protein kinase 1, SULFATE ION
Authors:Yokoyama, T.
Deposit date:2023-02-15
Release date:2023-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Characterization of the molecular interactions between resveratrol derivatives and death-associated protein kinase 1.
Febs J., 290, 2023
8IE7
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BU of 8ie7 by Molmil
Crystal structure of DAPK1 in complex with pterostilbene
Descriptor: Death-associated protein kinase 1, Pterostilbene, SULFATE ION
Authors:Yokoyama, T.
Deposit date:2023-02-15
Release date:2023-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Characterization of the molecular interactions between resveratrol derivatives and death-associated protein kinase 1.
Febs J., 290, 2023
3U2J
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BU of 3u2j by Molmil
Neutron crystal structure of human Transthyretin
Descriptor: Transthyretin
Authors:Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N.
Deposit date:2011-10-03
Release date:2012-02-22
Last modified:2023-11-01
Method:NEUTRON DIFFRACTION (2 Å)
Cite:Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin
J.Struct.Biol., 177, 2012
3U2I
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BU of 3u2i by Molmil
X-ray crystal structure of human Transthyretin at room temperature
Descriptor: Transthyretin
Authors:Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N.
Deposit date:2011-10-03
Release date:2012-02-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin
J.Struct.Biol., 177, 2012
4PWF
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BU of 4pwf by Molmil
Crystal structure of V30M mutant human transthyretin complexed with ferulic acid phenethyl ester
Descriptor: 2-phenylethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate, Transthyretin
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWH
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BU of 4pwh by Molmil
Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester
Descriptor: 3-methylbut-2-en-1-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, CALCIUM ION, Transthyretin
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWI
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BU of 4pwi by Molmil
Crystal structure of V30M mutant human transthyretin complexed with rosmarinic acid
Descriptor: (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, Transthyretin
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.494 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWE
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BU of 4pwe by Molmil
Crystal structure of V30M mutant human transthyretin
Descriptor: Transthyretin
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWJ
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BU of 4pwj by Molmil
Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid
Descriptor: 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Transthyretin
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWG
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BU of 4pwg by Molmil
Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester
Descriptor: CALCIUM ION, Transthyretin, ethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4PWK
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BU of 4pwk by Molmil
Crystal structure of V30M mutant human transthyretin complexed with dihydroguaiaretic acid
Descriptor: 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol), Transthyretin
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
4QRF
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BU of 4qrf by Molmil
Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester
Descriptor: 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, Transthyretin
Authors:Yokoyama, T, Kosaka, Y, Mizuguchi, M.
Deposit date:2014-06-30
Release date:2014-11-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin
J.Med.Chem., 57, 2014
5H0Z
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BU of 5h0z by Molmil
Crystal structure of P113A mutated human transthyretin
Descriptor: CHLORIDE ION, SULFATE ION, Transthyretin
Authors:Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
Deposit date:2016-10-07
Release date:2017-06-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.735 Å)
Cite:Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
5H0X
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BU of 5h0x by Molmil
Crystal structure of H88S mutated human transthyretin
Descriptor: Transthyretin
Authors:Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
Deposit date:2016-10-07
Release date:2017-06-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.573 Å)
Cite:Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
5H0V
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BU of 5h0v by Molmil
Crystal structure of H88A mutated human transthyretin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, Transthyretin
Authors:Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
Deposit date:2016-10-07
Release date:2017-06-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
3J0E
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BU of 3j0e by Molmil
Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex
Descriptor: 30S ribosomal protein S12, Elongation factor G, Ribosome-recycling factor, ...
Authors:Yokoyama, T, Shaikh, T.R, Iwakura, N, Kaji, H, Kaji, A, Agrawal, R.K.
Deposit date:2011-06-29
Release date:2012-04-25
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (9.9 Å)
Cite:Structural insights into initial and intermediate steps of the ribosome-recycling process.
Embo J., 31, 2012
5H0W
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BU of 5h0w by Molmil
Crystal structure of H88F mutated human transthyretin
Descriptor: SULFATE ION, Transthyretin
Authors:Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
Deposit date:2016-10-07
Release date:2017-06-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
5H0Y
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BU of 5h0y by Molmil
Crystal structure of H88Y mutated human transthyretin
Descriptor: CHLORIDE ION, SULFATE ION, Transthyretin
Authors:Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M.
Deposit date:2016-10-07
Release date:2017-06-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stability and crystal structures of His88 mutant human transthyretins
FEBS Lett., 591, 2017
5AYT
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BU of 5ayt by Molmil
Crystal structure of transthyretin in complex with L6
Descriptor: 2-oxidanyl-6-(phenylcarbonyl)benzo[de]isoquinoline-1,3-dione, Transthyretin
Authors:Yokoyama, T, Mizuguchi, M, Kai, H.
Deposit date:2015-09-03
Release date:2016-01-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
J. Pharmacol. Sci., 129, 2015
6AA5
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BU of 6aa5 by Molmil
Crystal structure of MTH1 in complex with 3-isomangostin
Descriptor: 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ...
Authors:Yokoyama, T, Kitakami, R, Mizuguchi, M.
Deposit date:2018-07-17
Release date:2019-03-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.
Eur J Med Chem, 167, 2019
6AJV
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BU of 6ajv by Molmil
Crystal structure of BRD4 in complex with isoliquiritigenin and DMSO (Cocktail No. 3)
Descriptor: 2',4,4'-TRIHYDROXYCHALCONE, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ...
Authors:Yokoyama, T, Matsumoto, K, Nabeshima, Y, Mizuguchi, M.
Deposit date:2018-08-28
Release date:2019-06-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4.
Febs J., 286, 2019
6AJX
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BU of 6ajx by Molmil
Crystal structure of BRD4 in complex with isoliquiritigenin in the absence of DMSO
Descriptor: 2',4,4'-TRIHYDROXYCHALCONE, Bromodomain-containing protein 4, SODIUM ION
Authors:Yokoyama, T, Matsumoto, K, Nabeshima, Y, Mizuguchi, M.
Deposit date:2018-08-28
Release date:2019-06-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.887 Å)
Cite:Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4.
Febs J., 286, 2019

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