5HJL
 
 | | Crystal structure of class I tagatose 1,6-bisphosphate aldolase LacD from Streptococcus porcinus | | Descriptor: | SULFATE ION, Tagatose 1,6-diphosphate aldolase | | Authors: | Freichels, R, Kerff, F, Herman, R, Charlier, P, Galleni, M. | | Deposit date: | 2016-01-13 | | Release date: | 2016-12-07 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure and Characterization of a new class I Tagatose-1,6-bipshosphate aldolase from Streptococcus porcinus : switch in specificity directed by an Arginine
To Be Published
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7AP7
 | | Structure of the W64R amyloidogenic variant of human lysozyme | | Descriptor: | Lysozyme C, SULFATE ION | | Authors: | Vettore, N, Herman, R, Kerff, F, Charlier, P, Sauvage, E, Brans, A, Morray, J, Dobson, C, Kumita, J, Dumoulin, M. | | Deposit date: | 2020-10-16 | | Release date: | 2021-08-25 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme.
Biophys.Chem., 271, 2021
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8ART
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6Y6L
 | | Structure the ananain protease from Ananas comosus with a thiomethylated catalytic cysteine | | Descriptor: | Ananain, GLYCEROL, SULFATE ION | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-02-26 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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6YCB
 | | Structure the ananain protease from Ananas comosus covalently bound to with the E64 inhibitor | | Descriptor: | Ananain, GLYCEROL, L(+)-TARTARIC ACID, ... | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-03-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.257 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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6YCE
 | | Structure the bromelain protease from Ananas comosus with a thiomethylated active cysteine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FBSB, ISOPROPYL ALCOHOL, ... | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-03-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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6YCF
 | | Structure the bromelain protease from Ananas comosus in complex with the E64 inhibitor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, FBSB, ... | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-03-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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6YCD
 | | Structure the ananain protease from Ananas comosus covalently bound to the TLCK inhibitor | | Descriptor: | Ananain, GLYCEROL, N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide, ... | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-03-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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6YCG
 | | Structure the bromelain protease from Ananas comosus in complex with the TLCK inhibitor | | Descriptor: | CITRIC ACID, FBSB, ISOPROPYL ALCOHOL, ... | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-03-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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6YCC
 | | Structure the ananain protease from Ananas comosus covalently bound to the E64 inhibitor | | Descriptor: | Ananain, GLYCEROL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, ... | | Authors: | Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. | | Deposit date: | 2020-03-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep, 10, 2020
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5OON
 | | Structure of Undecaprenyl-Pyrophosphate Phosphatase, BacA | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MERCURY (II) ION, ... | | Authors: | Huang, C.-Y, Olieric, V, Warshamanage, R, Wang, M, Howe, N, Ghachi, M.E.I, Weichert, D, Kerff, F, Stansfeld, P, Touze, T, Caffrey, M. | | Deposit date: | 2017-08-08 | | Release date: | 2018-03-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis.
Nat Commun, 9, 2018
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4M3K
 | | Structure of a single domain camelid antibody fragment cAb-H7S in complex with the BlaP beta-lactamase from Bacillus licheniformis | | Descriptor: | Beta-lactamase, CHLORIDE ION, Camelid heavy-chain antibody variable fragment cAb-H7S | | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | Deposit date: | 2013-08-06 | | Release date: | 2014-08-06 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To be Published
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4M3J
 | | Structure of a single-domain camelid antibody fragment cAb-H7S specific of the BlaP beta-lactamase from Bacillus licheniformis | | Descriptor: | Camelid heavy-chain antibody variable fragment cAb-H7S, SULFATE ION | | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | Deposit date: | 2013-08-06 | | Release date: | 2014-08-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To be Published
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4N1H
 | | Structure of a single-domain camelid antibody fragment cAb-F11N in complex with the BlaP beta-lactamase from Bacillus licheniformis | | Descriptor: | Beta-lactamase, Camelid heavy-chain antibody variable fragment cAb-F11N | | Authors: | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | Deposit date: | 2013-10-04 | | Release date: | 2014-10-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To be Published
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6G88
 | | Crystal structure of Enterococcus Faecium D63r Penicillin-Binding protein 5 (PBP5fm) | | Descriptor: | (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Low affinity penicillin-binding protein 5 (PBP5), SULFATE ION | | Authors: | Sauvage, E, El Gachi, M, Herman, R, Kerff, F, Charlier, P. | | Deposit date: | 2018-04-08 | | Release date: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural basis of inactivation of Enterococcus faecium penicillin binding protein 5 by ceftobiprole.
To Be Published
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2J9P
 | | Crystal structure of the Bacillus subtilis PBP4a, and its complex with a peptidoglycan mimetic peptide. | | Descriptor: | (2R)-2-AMINO-7-{[(1R)-1-CARBOXYETHYL]AMINO}-7-OXOHEPTANOIC ACID, D-ALANINE, D-alanyl-D-alanine carboxypeptidase DacC | | Authors: | Sauvage, E, Herman, R, Kerff, F, Duez, C, Charlier, P. | | Deposit date: | 2006-11-15 | | Release date: | 2007-07-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide.
J. Mol. Biol., 371, 2007
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2RL3
 | | Crystal structure of the OXA-10 W154H mutant at pH 7 | | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase PSE-2, GLYCEROL, ... | | Authors: | Vercheval, L, Kerff, F, Herman, R, Sauvage, E, Guiet, R, Charlier, P, Frere, J.-M, Galleni, M. | | Deposit date: | 2007-10-18 | | Release date: | 2008-10-28 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases.
Biochemistry, 48, 2009
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2WGW
 | | Crystal structure of the OXA-10 V117T mutant at pH 8.0 | | Descriptor: | BETA-LACTAMASE OXA-10, GLYCEROL, SULFATE ION | | Authors: | Vercheval, L, Kerff, F, Bauvois, C, Sauvage, E, Guiet, R, Charlier, P, Galleni, M. | | Deposit date: | 2009-04-27 | | Release date: | 2010-05-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post-Translational Carboxylation of Lys70.
Biochem.J., 432, 2010
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2WGV
 | | Crystal structure of the OXA-10 V117T mutant at pH 6.5 inhibited by a chloride ion | | Descriptor: | BETA-LACTAMASE OXA-10, CHLORIDE ION, CITRIC ACID, ... | | Authors: | Vercheval, L, Kerff, F, Bauvois, C, Sauvage, E, Guiet, R, Charlier, P, Galleni, M. | | Deposit date: | 2009-04-27 | | Release date: | 2010-05-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post- Translational Carboxylation of Lys70.
Biochem.J., 432, 2010
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2WGI
 | | Crystal structure of the acyl-enzyme OXA-10 W154A-benzylpenicillin at pH 6 | | Descriptor: | BETA-LACTAMASE OXA-10, GLYCEROL, OPEN FORM - PENICILLIN G | | Authors: | Vercheval, L, Falzone, C, Sauvage, E, Herman, R, Charlier, P, Galleni, M, Kerff, F. | | Deposit date: | 2009-04-20 | | Release date: | 2009-11-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Critical Role of Tryptophan 154 for the Activity and Stability of Class D Beta-Lactamases.
Biochemistry, 48, 2009
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2X01
 | | CRYSTAL STRUCTURE OF THE OXA-10 S67A MUTANT AT PH 7 | | Descriptor: | BETA-LACTAMASE OXA-10, DIMETHYL SULFOXIDE, SULFATE ION, ... | | Authors: | Vercheval, L, Kerff, F, Bauvois, C, Sauvage, E, Guiet, R, Galleni, M, Charlier, P. | | Deposit date: | 2009-12-04 | | Release date: | 2010-12-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Evidence of Chloride Inhibition and Impact of the Hydrophobic Core on the Lysine Carboxylated in Class D Beta-Lactamase
To be Published
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2WKI
 | | Crystal structure of the OXA-10 K70C mutant at pH 7.0 | | Descriptor: | 1,2-ETHANEDIOL, BETA-LACTAMASE OXA-10, GLYCEROL, ... | | Authors: | Vercheval, L, Bauvois, C, Kerff, F, Sauvage, E, Guiet, R, Charlier, P, Galleni, M. | | Deposit date: | 2009-06-11 | | Release date: | 2010-08-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post-Translational Carboxylation of Lys70.
Biochem.J., 432, 2010
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4BZG
 | | Crystal structure of galactose mutarotase GalM from Bacillus subtilis in complex with maltose | | Descriptor: | ALDOSE 1-EPIMERASE, CITRIC ACID, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Vanden Broeck, A, Sauvage, E, Herman, R, Kerff, F, Duez, C, Charlier, P. | | Deposit date: | 2013-07-25 | | Release date: | 2014-08-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Crystal Structure of Galactose Mutarotase Galm from Bacillus Subtilis in Complex with Maltose
To be Published
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4BZH
 | | Crystal structure of galactose mutarotase GalM from Bacillus subtilis in complex with maltose and trehalose | | Descriptor: | ALDOSE 1-EPIMERASE, CITRIC ACID, GLYCEROL, ... | | Authors: | Vanden Broeck, A, Sauvage, E, Herman, R, Kerff, F, Duez, C, Charlier, P. | | Deposit date: | 2013-07-25 | | Release date: | 2014-08-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of Galactose Mutarotase Galm from Bacillus Subtilis in Complex with Maltose and Trehalose
To be Published
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4BZF
 | | Crystal structure of galactose mutarotase GalM from Bacillus subtilis with trehalose | | Descriptor: | ACETATE ION, ALDOSE 1-EPIMERASE, CITRIC ACID, ... | | Authors: | Vanden Broeck, A, Sauvage, E, Herman, R, Kerff, F, Duez, C, Charlier, P. | | Deposit date: | 2013-07-25 | | Release date: | 2014-08-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of Galactose Mutarotase Galm from Bacillus Subtilis with Trehalose
To be Published
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