3OXQ
 
 | | Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex | | Descriptor: | CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel subunit alpha-1C | | Authors: | Kim, E.Y, Rumpf, C.H, Van Petegem, F, Arant, R, Findeisen, F, Cooley, E.S, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2010-09-21 | | Release date: | 2010-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.
Embo J., 29, 2010
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3HRO
 | | Crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2, polycystic kidney disease 2) | | Descriptor: | Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2), also called Polycystin-2 or polycystic kidney disease 2(PKD2) | | Authors: | Yu, Y, Ulbrich, M.H, Li, M.-H, Buraei, Z, Chen, X.-Z, Ong, A.C.M, Tong, L, Isacoff, E.Y, Yang, J. | | Deposit date: | 2009-06-09 | | Release date: | 2009-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3HRN
 | | crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2, polycystic kidney disease 2) | | Descriptor: | Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2) | | Authors: | Yu, Y, Ulbrich, M.H, Li, M.-H, Buraei, Z, Chen, X.-Z, Ong, A.C.M, Tong, L, Isacoff, E.Y, Yang, J. | | Deposit date: | 2009-06-09 | | Release date: | 2009-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
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4GIF
 | | C-terminal coiled-coil domain of transient receptor potential channel TRPP3 (PKD2L1, Polycystin-L) | | Descriptor: | Polycystic kidney disease 2-like 1 protein | | Authors: | Yu, Y, Ulbrich, M.H, Li, M.-H, Dobbins, S, Zhang, W.K, Tong, L, Isacoff, E.Y, Yang, J. | | Deposit date: | 2012-08-08 | | Release date: | 2012-12-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex.
Nat Commun, 3, 2012
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3V0I
 | | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 256-576, E411F | | Descriptor: | SULFATE ION, Voltage-sensor containing phosphatase | | Authors: | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2011-12-08 | | Release date: | 2012-05-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | A glutamate switch controls voltage-sensitive phosphatase function.
Nat.Struct.Mol.Biol., 19, 2012
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3V0D
 | | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 241-576(C363S) | | Descriptor: | PHOSPHATE ION, Voltage-sensor containing phosphatase | | Authors: | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2011-12-07 | | Release date: | 2012-05-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | A glutamate switch controls voltage-sensitive phosphatase function.
Nat.Struct.Mol.Biol., 19, 2012
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3V0F
 | | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 241-576(C363S), form II | | Descriptor: | PHOSPHATE ION, Voltage-sensor containing phosphatase | | Authors: | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2011-12-07 | | Release date: | 2012-05-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | A glutamate switch controls voltage-sensitive phosphatase function.
Nat.Struct.Mol.Biol., 19, 2012
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3V0G
 | | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 241-576(C363S), form III | | Descriptor: | PHOSPHATE ION, Voltage-sensor containing phosphatase | | Authors: | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2011-12-08 | | Release date: | 2012-05-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A glutamate switch controls voltage-sensitive phosphatase function.
Nat.Struct.Mol.Biol., 19, 2012
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3V0J
 | | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 241-576(C363S), Deletion of 401-405 | | Descriptor: | PHOSPHATE ION, Voltage-sensor containing phosphatase | | Authors: | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2011-12-08 | | Release date: | 2012-05-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | A glutamate switch controls voltage-sensitive phosphatase function.
Nat.Struct.Mol.Biol., 19, 2012
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3V0E
 | | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 256-576(C363S) | | Descriptor: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | | Authors: | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2011-12-07 | | Release date: | 2012-05-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | A glutamate switch controls voltage-sensitive phosphatase function.
Nat.Struct.Mol.Biol., 19, 2012
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3V0H
 | | Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), residues 241-576(C363S), complexed with D-MYO-inositol-1,4,5-triphosphate | | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Voltage-sensor containing phosphatase | | Authors: | Liu, L, Kohout, S.C, Xu, Q, Muller, S, Kimberlin, C, Isacoff, E.Y, Minor, D.L. | | Deposit date: | 2011-12-08 | | Release date: | 2012-05-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A glutamate switch controls voltage-sensitive phosphatase function.
Nat.Struct.Mol.Biol., 19, 2012
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8T8M
 | | Quis-bound intermediate mGlu5 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nb43 | | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | | Deposit date: | 2023-06-22 | | Release date: | 2023-10-11 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
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8T6J
 | | CDPPB-bound inactive mGlu5 | | Descriptor: | 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, Metabotropic glutamate receptor 5 | | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | | Deposit date: | 2023-06-16 | | Release date: | 2023-10-11 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
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8TAO
 | | Quis and CDPPB bound active mGlu5 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, Metabotropic glutamate receptor 5, ... | | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | | Deposit date: | 2023-06-27 | | Release date: | 2023-10-11 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
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8T7H
 | | Quis-bound intermediate mGlu5 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nanobody 43 | | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | | Deposit date: | 2023-06-20 | | Release date: | 2023-10-11 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
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8FU6
 | | GCGR-Gs complex in the presence of RAMP2 | | Descriptor: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Krishna Kumar, K, O'Brien, E.S, Wang, H, Montabana, E, Kobilka, B.K. | | Deposit date: | 2023-01-16 | | Release date: | 2023-04-12 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Negative allosteric modulation of the glucagon receptor by RAMP2.
Cell, 186, 2023
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9C49
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9BUY
 | | Structure of the LM189-Bound beta2AR-Gi Complex | | Descriptor: | 4-[(1R)-1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl]benzene-1,2-diol, Beta-2 adrenergic receptor, CHOLESTEROL, ... | | Authors: | Casiraghi, M, Wang, H, Kobilka, B.K. | | Deposit date: | 2024-05-17 | | Release date: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure and dynamics determine G protein coupling specificity at a class A GPCR.
Sci Adv, 11, 2025
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8UEC
 | | Structure of TREK-1CG*:CAT335a | | Descriptor: | CADMIUM ION, DECANE, HEXADECANE, ... | | Authors: | Mondal, A, Lee, H, Minor, D.L. | | Deposit date: | 2023-09-30 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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8UF6
 | | Structure of Trek-1(K2P2.1) with ML336 | | Descriptor: | CADMIUM ION, DECANE, DODECANE, ... | | Authors: | Lolicato, M, Mondal, A, Minor, D.L. | | Deposit date: | 2023-10-03 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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8UE2
 | | Structure of TREK-1CG*:ML335 | | Descriptor: | CADMIUM ION, DECANE, HEXADECANE, ... | | Authors: | Mondal, A, Lee, H, Minor, D.L. | | Deposit date: | 2023-09-29 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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8UE9
 | | Structure of TREK-1CG*:CAT335 | | Descriptor: | CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... | | Authors: | Mondal, A, Lee, H, Minor, D.L. | | Deposit date: | 2023-09-29 | | Release date: | 2024-06-26 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Development of covalent chemogenetic K 2P channel activators.
Cell Chem Biol, 31, 2024
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4H8J
 | | Structure of GluA2-LBD in complex with MES | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glutamate receptor 2, ... | | Authors: | Reiter, A, Skerra, A, Trauner, D, Schiefner, A. | | Deposit date: | 2012-09-22 | | Release date: | 2013-09-25 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis of an artificial photoreceptor
To be Published
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8DS9
 | | LRRC8A:C in MSPE3D1 nanodisc top focus | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | Authors: | Kern, D.M, Brohawn, S.G. | | Deposit date: | 2022-07-21 | | Release date: | 2023-03-08 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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8DR8
 | | LRRC8A:C conformation 2 (oblong) top mask | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | | Authors: | Kern, D.M, Brohawn, S.G. | | Deposit date: | 2022-07-20 | | Release date: | 2023-03-08 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
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