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7F98
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BU of 7f98 by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
Descriptor: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
Authors:Malhotra, N, Manickam, Y, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9A
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BU of 7f9a by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L97
Descriptor: 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
Authors:Manickam, Y, Malhotra, N, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9D
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BU of 7f9d by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96
Descriptor: 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, ...
Authors:Manickam, Y, Malhotra, N, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7FAN
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BU of 7fan by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T35 and L-pro
Descriptor: 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS)
Authors:Mishra, S, Malhotra, N, Yogavel, M, Sharma, A.
Deposit date:2021-07-06
Release date:2022-09-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7F9B
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BU of 7f9b by Molmil
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95
Descriptor: Bifunctional glutamate/proline--tRNA ligase, CALCIUM ION, CHLORIDE ION, ...
Authors:Manickam, Y, Malhotra, N, Sharma, A.
Deposit date:2021-07-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7FAM
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BU of 7fam by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L97 and L-pro
Descriptor: 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS)
Authors:Mishra, S, Malhotra, N, Yogavel, M, Sharma, A.
Deposit date:2021-07-06
Release date:2022-09-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7FAK
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BU of 7fak by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L96 and L-pro
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ACETATE ION, ...
Authors:Malhotra, N, Mishra, S, Yogavel, M, Sharma, A.
Deposit date:2021-07-06
Release date:2023-02-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
6I9I
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BU of 6i9i by Molmil
Rift valley fever virus Gn in complex with a neutralizing antibody fragment
Descriptor: Glycoprotein, RV-Gn1 Heavy chain, RV-Gn1 Light chain
Authors:Allen, E.R, Bowden, T.A.
Deposit date:2018-11-23
Release date:2018-12-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus.
Cell Rep, 25, 2018
1DR9
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BU of 1dr9 by Molmil
CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, T LYMPHOCYTE ACTIVATION ANTIGEN
Authors:Ikemizu, S, Jones, E.Y, Stuart, D.I, Davis, S.J.
Deposit date:2000-01-06
Release date:2000-01-10
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and dimerization of a soluble form of B7-1.
Immunity, 12, 2000
6F9C
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BU of 6f9c by Molmil
Model of the Rift Valley fever virus glycoprotein hexamer type 1
Descriptor: Glycoprotein
Authors:Halldorsson, S, Bowden, T.A, Huiskonen, J.T.
Deposit date:2017-12-14
Release date:2018-01-31
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Shielding and activation of a viral membrane fusion protein.
Nat Commun, 9, 2018
6F9E
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BU of 6f9e by Molmil
Model of the Rift Valley fever virus glycoprotein hexamer type 3
Descriptor: Glycoprotein
Authors:Halldorsson, S, Bowden, T.A, Huiskonen, J.T.
Deposit date:2017-12-14
Release date:2018-01-31
Last modified:2018-03-07
Method:ELECTRON MICROSCOPY (13.3 Å)
Cite:Shielding and activation of a viral membrane fusion protein.
Nat Commun, 9, 2018
6F9D
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BU of 6f9d by Molmil
Model of the Rift Valley fever virus glycoprotein hexamer type 2
Descriptor: Glycoprotein
Authors:Halldorsson, S, Bowden, T.A, Huiskonen, J.T.
Deposit date:2017-12-14
Release date:2018-01-31
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (13.3 Å)
Cite:Shielding and activation of a viral membrane fusion protein.
Nat Commun, 9, 2018
6F9B
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BU of 6f9b by Molmil
Asymmetric unit of Rift Valley fever virus glycoprotein shell
Descriptor: Glycoprotein
Authors:Halldorsson, S, Bowden, T.A, Huiskonen, J.T.
Deposit date:2017-12-14
Release date:2018-01-31
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (13.3 Å)
Cite:Shielding and activation of a viral membrane fusion protein.
Nat Commun, 9, 2018
6F9F
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BU of 6f9f by Molmil
Model of the Rift Valley fever virus glycoprotein pentamer
Descriptor: Glycoprotein
Authors:Halldorsson, S, Bowden, T.A, Huiskonen, J.T.
Deposit date:2017-12-14
Release date:2018-01-31
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (13.3 Å)
Cite:Shielding and activation of a viral membrane fusion protein.
Nat Commun, 9, 2018
6GBI
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BU of 6gbi by Molmil
Wnt signalling
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ly6/PLAUR domain-containing protein 6, ...
Authors:Zhao, Y, Jones, E.Y.
Deposit date:2018-04-14
Release date:2018-08-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6.
FEBS Lett., 592, 2018
5XII
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BU of 5xii by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6
Descriptor: 1,2-ETHANEDIOL, 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIL
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BU of 5xil by Molmil
Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS)
Descriptor: ACETATE ION, MAGNESIUM ION, Putative prolyl-tRNA synthetase, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIG
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BU of 5xig by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1
Descriptor: 3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIP
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BU of 5xip by Molmil
Crystal Structure of Eimeria tenella Prolyl-tRNA Synthetase (EtPRS) in complex with Halofuginone
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIK
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BU of 5xik by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with tetrahydro quinazolinone febrifugine
Descriptor: 3-[2-oxidanylidene-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]-5,6,7,8-tetrahydroquinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIJ
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BU of 5xij by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9
Descriptor: 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIH
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BU of 5xih by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 5
Descriptor: 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIO
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BU of 5xio by Molmil
Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase), ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5ZKG
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BU of 5zkg by Molmil
Crystal Structure of C-terminal Domain of Plasmodium vivax p43
Descriptor: Aminoacyl-tRna synthetase-interacting multifunctional protein P43
Authors:Gupta, S, Sharma, M, Manickam, Y, Sharma, A.
Deposit date:2018-03-23
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.
Acta Crystallogr D Struct Biol, 76, 2020
5Z79
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BU of 5z79 by Molmil
Crystal Structure Analysis of the HPPK-DHPS in complex with substrates
Descriptor: 4-AMINOBENZOIC ACID, 5'-DEOXYADENOSINE, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ...
Authors:Manickam, Y, Karl, H, Sharma, A.
Deposit date:2018-01-27
Release date:2018-08-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
J. Biol. Chem., 293, 2018

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