5XIL

Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS)

Summary for 5XIL

Entry DOI	10.2210/pdb5xil/pdb
Related	5XIF 5XIG 5XIH 5XII 5XIJ 5XIK 5XIO 5XIP 5XIR
Descriptor	Putative prolyl-tRNA synthetase, ZINC ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	protein translation, prs, synthetase, inhibitor, infectious disease, ligase
Biological source	Leishmania major
Total number of polymer chains	1
Total formula weight	58768.96
Authors	Jain, V.,Manickam, Y.,Sharma, A. (deposition date: 2017-04-26, release date: 2018-03-07, Last modification date: 2023-11-22)
Primary citation	Jain, V.,Yogavel, M.,Kikuchi, H.,Oshima, Y.,Hariguchi, N.,Matsumoto, M.,Goel, P.,Touquet, B.,Jumani, R.S.,Tacchini-Cottier, F.,Harlos, K.,Huston, C.D.,Hakimi, M.A.,Sharma, A. Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25:1495-1505.e6, 2017 Cited by PubMed: 28867614 DOI: 10.1016/j.str.2017.07.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation