6Y39
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2BHO
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3D29
| Proteasome Inhibition by Fellutamide B | 分子名称: | (3R)-3-HYDROXYDODECANOIC ACID, Fellutamide B, PRE10 isoform 1, ... | 著者 | Groll, M, Hines, J, Fahnestock, M, Crews, M.C. | 登録日 | 2008-05-07 | 公開日 | 2008-06-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis Chem.Biol., 15, 2008
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3GPJ
| Crystal structure of the yeast 20S proteasome in complex with syringolin B | 分子名称: | N-{[(1S)-2-methyl-1-{[(5S,8S)-5-(1-methylethyl)-2,7-dioxo-1,6-diazacyclododec-3-en-8-yl]carbamoyl}propyl]carbamoyl}-L-valine, Proteasome component C1, Proteasome component C11, ... | 著者 | Groll, M, Huber, R, Kaiser, M. | 登録日 | 2009-03-23 | 公開日 | 2009-06-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition Proc.Natl.Acad.Sci.USA, 106, 2009
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3OKJ
| Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition | 分子名称: | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S,3S)-3-hydroxy-1-(4-hydroxyphenyl)-4-oxobutan-2-yl]-L-leucinamide, Proteasome component C1, Proteasome component C11, ... | 著者 | Groll, M, Poynor, M, Gallastegui, P, Stein, M, Schmidt, B, Kloetzel, P.M, Huber, R. | 登録日 | 2010-08-25 | 公開日 | 2011-06-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition Angew.Chem.Int.Ed.Engl., 50, 2011
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6EOZ
| Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AsqJ_V72K mutant in complex with cyclopeptin (1b) | 分子名称: | 2-OXOGLUTARIC ACID, Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, NICKEL (II) ION, ... | 著者 | Groll, M, Braeuer, A, Kaila, V.R.I. | 登録日 | 2017-10-10 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ. Nat Commun, 9, 2018
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6G7F
| Yeast 20S proteasome in complex with Cystargolide B | 分子名称: | CHLORIDE ION, Cystargolide B- bound form, MAGNESIUM ION, ... | 著者 | Groll, M, Tello-Aburto, R. | 登録日 | 2018-04-05 | 公開日 | 2018-09-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors. Eur J Med Chem, 157, 2018
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6G8M
| Yeast 20S proteasome in complex with Cystargolide B Derivative 1 | 分子名称: | (2~{S},3~{R})-4-[[(2~{S})-3-methyl-1-[[(2~{S})-3-methyl-1-oxidanylidene-1-phenylmethoxy-butan-2-yl]amino]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanyl-4-oxidanylidene-2-propan-2-yl-butanoic acid, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Groll, M, Tello-Aburto, R. | 登録日 | 2018-04-09 | 公開日 | 2018-09-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors. Eur J Med Chem, 157, 2018
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3KEF
| Crystal structure of IspH:DMAPP-complex | 分子名称: | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, DIMETHYLALLYL DIPHOSPHATE, FE3-S4 CLUSTER | 著者 | Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A. | 登録日 | 2009-10-26 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc.Natl.Acad.Sci.USA, 107, 2010
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3KE9
| Crystal structure of IspH:Intermediate-complex | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER | 著者 | Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A. | 登録日 | 2009-10-24 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc.Natl.Acad.Sci.USA, 107, 2010
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3KEL
| Crystal Structure of IspH:PP complex | 分子名称: | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, PYROPHOSPHATE 2- | 著者 | Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A. | 登録日 | 2009-10-26 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc.Natl.Acad.Sci.USA, 107, 2010
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3KEM
| Crystal structure of IspH:IPP complex | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER | 著者 | Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A. | 登録日 | 2009-10-26 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc.Natl.Acad.Sci.USA, 107, 2010
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3KE8
| Crystal structure of IspH:HMBPP-complex | 分子名称: | 4-HYDROXY-3-METHYL BUTYL DIPHOSPHATE, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER | 著者 | Groll, M, Graewert, T, Span, I, Eisenreich, W, Bacher, A. | 登録日 | 2009-10-24 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc.Natl.Acad.Sci.USA, 107, 2010
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3MHP
| FNR-recruitment to the thylakoid | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Ferredoxin--NADP reductase, leaf isozyme, ... | 著者 | Groll, M, Alte, F, Soll, J, Boelter, B. | 登録日 | 2010-04-08 | 公開日 | 2010-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner. Proc.Natl.Acad.Sci.USA, 107, 2010
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3NOY
| Crystal structure of IspG (gcpE) | 分子名称: | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, IRON/SULFUR CLUSTER | 著者 | Groll, M, Graewert, T, Bacher, A. | 登録日 | 2010-06-26 | 公開日 | 2010-11-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG. J.Mol.Biol., 404, 2010
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4GK7
| yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera | 分子名称: | Proteasome component C1, Proteasome component C11, Proteasome component C5, ... | 著者 | Groll, M, Stein, M.L, Bachmann, A. | 登録日 | 2012-08-10 | 公開日 | 2012-08-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells. Biochemistry, 51, 2012
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7NCB
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7NC9
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7NCM
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7NCU
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7NCT
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7NC2
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7NCE
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7NCL
| Glutathione-S-transferase GliG mutant E82Q | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Glutathione S-transferase GliG | 著者 | Groll, M, Huber, E.M. | 登録日 | 2021-01-29 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and Mechanistic Insights into C-S Bond Formation in Gliotoxin. Angew.Chem.Int.Ed.Engl., 60, 2021
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7NC1
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