6G8M

Yeast 20S proteasome in complex with Cystargolide B Derivative 1

Summary for 6G8M

• Entry DOI: 10.2210/pdb6g8m/pdb
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: proteasome, inhibitor, beta lactone; natural product derivative, binding analysis, hydrolase
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 28
• Total formula weight: 734103.43

Authors

Groll, M.,Tello-Aburto, R. (deposition date: 2018-04-09, release date: 2018-09-12, Last modification date: 2024-01-17)

• Primary citation: Niroula, D.,Hallada, L.P.,Le Chapelain, C.,Ganegamage, S.K.,Dotson, D.,Rogelj, S.,Groll, M.,Tello-Aburto, R.; Design, synthesis, and evaluation of cystargolide-based beta-lactones as potent proteasome inhibitors.; Eur J Med Chem, 157:962-977, 2018; PubMed: 30165344; DOI: 10.1016/j.ejmech.2018.08.052

Experimental method

X-RAY DIFFRACTION (2.7 Å)