Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition

Summary for 3OKJ

Related1RYP 1J2Q 3D29 1G65
Related PRD IDPRD_001051
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (16 entities in total)
Functional Keywordsubiquitin, protease, inhibitor, central antiparallel beta-sheet flanked by helices, turnover of ubiquitinated substrates, nucleus, cytosol, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight705317.56
Groll, M.,Poynor, M.,Gallastegui, P.,Stein, M.,Schmidt, B.,Kloetzel, P.M.,Huber, R. (deposition date: 2010-08-25, release date: 2011-06-08, Last modification date: 2018-01-24)
Primary citation
Grawert, M.A.,Gallastegui, N.,Stein, M.,Schmidt, B.,Kloetzel, P.M.,Huber, R.,Groll, M.
Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition
Angew.Chem.Int.Ed.Engl., 50:542-544, 2011
PubMed: 21154547 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201005488
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.224211.4%5.4%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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