4MXI
 
 | | ClpP Ser98dhA | | 分子名称: | ATP-dependent Clp protease proteolytic subunit | | 著者 | Gersch, M, Kolb, R, Alte, F, Groll, M, Sieber, S.A. | | 登録日 | 2013-09-26 | | 公開日 | 2013-10-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition.
J.Am.Chem.Soc., 136, 2014
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3V5E
 | | Crystal structure of ClpP from Staphylococcus aureus in the active, extended conformation | | 分子名称: | ATP-dependent Clp protease proteolytic subunit | | 著者 | Gersch, M, List, A, Groll, M, Sieber, S. | | 登録日 | 2011-12-16 | | 公開日 | 2012-02-08 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
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5OHP
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5OHK
 | | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, ... | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2017-07-17 | | 公開日 | 2017-09-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
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5OHN
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6HEM
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6HEJ
 | | Structure of human USP28 | | 分子名称: | SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28 | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
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6HEH
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6HEI
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6HEL
 | | Structure of human USP25 | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 25 | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.941 Å) | | 主引用文献 | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
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6HEK
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3V5I
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8BS3
 | | Structure of USP36 in complex with Fubi-PA | | 分子名称: | 40S ribosomal protein S30, Ubiquitin carboxyl-terminal hydrolase 36, ZINC ION, ... | | 著者 | O'Dea, R, Gersch, M. | | 登録日 | 2022-11-24 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36.
Nat.Chem.Biol., 19, 2023
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8BS9
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8PQ0
 | | Structure of human PARK7 in complex with GK16R | | 分子名称: | (3~{R})-3-(pent-4-ynylcarbamoyl)pyrrolidine-1-carboximidothioic acid, Parkinson disease protein 7 | | 著者 | Grethe, C, Gersch, M. | | 登録日 | 2023-07-10 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8PPW
 | | Structure of human PARK7 in complex with GK16S | | 分子名称: | (3~{S})-1-(iminomethyl)-~{N}-pent-4-ynyl-pyrrolidine-3-carboxamide, Parkinson disease protein 7 | | 著者 | Grethe, C, Gersch, M. | | 登録日 | 2023-07-10 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8PW1
 | | Structure of human UCHL1 in complex with CG341 inhibitor | | 分子名称: | (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | | 著者 | Grethe, C, Gersch, M. | | 登録日 | 2023-07-19 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
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4R17
 | | Ligand-induced aziridine-formation at subunit beta5 of the yeast 20S proteasome | | 分子名称: | (2S,3S)-3-methylaziridine-2-carboxylic acid, MAGNESIUM ION, Proteasome subunit alpha type-1, ... | | 著者 | Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M. | | 登録日 | 2014-08-04 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4R18
 | | Ligand-induced Lys33-Thr1 crosslinking at subunit beta5 of the yeast 20S proteasome | | 分子名称: | ALPHA-AMINOBUTYRIC ACID, MAGNESIUM ION, PROTEASOME SUBUNIT ALPHA TYPE-1, ... | | 著者 | Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M. | | 登録日 | 2014-08-04 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
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7ZM0
 | | Structure of UCHL1 in complex with GK13S inhibitor | | 分子名称: | (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | | 著者 | Grethe, C, Gersch, M. | | 登録日 | 2022-04-18 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Structural basis for specific inhibition of the deubiquitinase UCHL1.
Nat Commun, 13, 2022
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7ZJU
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7ZJV
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4JCR
 | | ClpP1 N165D mutant from Listeria monocytogenes | | 分子名称: | ATP-dependent Clp protease proteolytic subunit | | 著者 | Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S. | | 登録日 | 2013-02-22 | | 公開日 | 2013-06-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4JCQ
 | | ClpP1 from Listeria monocytogenes | | 分子名称: | ATP-dependent Clp protease proteolytic subunit | | 著者 | Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S. | | 登録日 | 2013-02-22 | | 公開日 | 2013-06-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4JCT
 | | ClpP2 from Listeria monocytogenes | | 分子名称: | ATP-dependent Clp protease proteolytic subunit | | 著者 | Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S. | | 登録日 | 2013-02-22 | | 公開日 | 2013-06-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
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