9HVP
| Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease | Descriptor: | HIV-1 Protease, benzyl [(1R,4S,6S,9R)-4,6-dibenzyl-5-hydroxy-1,9-bis(1-methylethyl)-2,8,11-trioxo-13-phenyl-12-oxa-3,7,10-triazatridec-1-yl]carbamate | Authors: | Neidhart, D.J, Erickson, J. | Deposit date: | 1990-11-06 | Release date: | 1992-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease. Science, 249, 1990
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4FE6
| Crystal Structure of HIV-1 Protease in Complex with an enamino-oxindole inhibitor | Descriptor: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[({(3Z)-3-[1-(methylamino)ethylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl}sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate, HIV protease | Authors: | Silva, A.M, Eissenstat, M, Guerassina, T, Gulnik, S, Afonina, E, Yu, B, Erickson, J, Ludke, D, Yokoe, H. | Deposit date: | 2012-05-29 | Release date: | 2012-07-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Enamino-oxindole HIV protease inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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1RWJ
| c7-type three-heme cytochrome domain | Descriptor: | Cytochrome c family protein, HEME C | Authors: | Pokkuluri, P.R, Londer, Y.Y, Duke, N.E.C, Erickson, J, Pessanha, M, Salgueiro, C.A, Schiffer, M. | Deposit date: | 2003-12-16 | Release date: | 2004-08-03 | Last modified: | 2021-03-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of a novel c7-type three-heme cytochrome domain from a multidomain cytochrome c polymer. Protein Sci., 13, 2004
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1LYW
| CATHEPSIN D AT PH 7.5 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CATHEPSIN D | Authors: | Lee, A.Y, Gulnik, S.V, Erickson, J.W. | Deposit date: | 1998-06-30 | Release date: | 1999-07-22 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Conformational switching in an aspartic proteinase. Nat.Struct.Biol., 5, 1998
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1LYB
| CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATHEPSIN D, PEPSTATIN, ... | Authors: | Baldwin, E.T, Bhat, T.N, Gulnik, S, Erickson, J.W. | Deposit date: | 1993-04-22 | Release date: | 1994-01-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design. Proc.Natl.Acad.Sci.USA, 90, 1993
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1LYA
| CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATHEPSIN D, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Baldwin, E.T, Bhat, T.N, Gulnik, S, Erickson, J.W. | Deposit date: | 1993-04-22 | Release date: | 1994-01-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design. Proc.Natl.Acad.Sci.USA, 90, 1993
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3PEP
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3OUQ
| Structure of N-terminal hexaheme fragment of GSU1996 | Descriptor: | Cytochrome c family protein, HEME C | Authors: | Pokkuluri, P.R, Schiffer, M. | Deposit date: | 2010-09-15 | Release date: | 2010-12-29 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of a novel dodecaheme cytochrome c from Geobacter sulfurreducens reveals an extended 12nm protein with interacting hemes. J.Struct.Biol., 174, 2011
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3OV0
| Structure of dodecaheme cytochrome c GSU1996 | Descriptor: | Cytochrome c family protein, HEME C | Authors: | Pokkuluri, P.R, Schiffer, M. | Deposit date: | 2010-09-15 | Release date: | 2010-12-29 | Last modified: | 2021-03-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of a novel dodecaheme cytochrome c from Geobacter sulfurreducens reveals an extended 12nm protein with interacting hemes. J.Struct.Biol., 174, 2011
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3OUE
| Structure of C-terminal hexaheme fragment of GSU1996 | Descriptor: | Cytochrome c family protein, HEME C, SULFATE ION | Authors: | Pokkuluri, P.R, Schiffer, M. | Deposit date: | 2010-09-14 | Release date: | 2010-12-29 | Last modified: | 2021-03-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of a novel dodecaheme cytochrome c from Geobacter sulfurreducens reveals an extended 12nm protein with interacting hemes. J.Struct.Biol., 174, 2011
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1PSA
| STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR | Descriptor: | N-(ethoxycarbonyl)-L-leucyl-N-[(1R,2S,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-leucinamide, PEPSIN A | Authors: | Chen, L, Abad-Zapatero, C. | Deposit date: | 1991-10-22 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor. Acta Crystallogr.,Sect.B, 48, 1992
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7KPY
| Crystal structure of CBP bromodomain liganded with UMB298 (compound 23) | Descriptor: | 1,2-ETHANEDIOL, 2-[2-(3-chloranyl-4-methoxy-phenyl)ethyl]-~{N}-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine, Histone acetyltransferase | Authors: | Schonbrunn, E, Bikowitz, M. | Deposit date: | 2020-11-12 | Release date: | 2021-05-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Development of Dimethylisoxazole-Attached Imidazo[1,2- a ]pyridines as Potent and Selective CBP/P300 Inhibitors. J.Med.Chem., 64, 2021
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3H4N
| PpcD, A cytochrome c7 from Geobacter sulfurreducens | Descriptor: | Cytochrome c7, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Pokkuluri, P.R, Schiffer, M. | Deposit date: | 2009-04-20 | Release date: | 2009-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural characterization of a family of cytochromes c(7) involved in Fe(III) respiration by Geobacter sulfurreducens. Biochim.Biophys.Acta, 1797, 2010
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3H33
| PpcC, A cytochrome c7 from Geobacter sulfurreducens | Descriptor: | Cytochrome c7, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Pokkuluri, P.R, Schiffer, M. | Deposit date: | 2009-04-15 | Release date: | 2009-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural characterization of a family of cytochromes c(7) involved in Fe(III) respiration by Geobacter sulfurreducens. Biochim.Biophys.Acta, 1797, 2010
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3H34
| PpcE, A cytochrome c7 from Geobacter sulfurreducens | Descriptor: | Cytochrome c7, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Pokkuluri, P.R, Schiffer, M. | Deposit date: | 2009-04-15 | Release date: | 2009-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural characterization of a family of cytochromes c(7) involved in Fe(III) respiration by Geobacter sulfurreducens. Biochim.Biophys.Acta, 1797, 2010
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4PHV
| X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY | Descriptor: | HIV-1 PROTEASE, N,N-BIS(2-HYDROXY-1-INDANYL)-2,6- DIPHENYLMETHYL-4-HYDROXY-1,7-HEPTANDIAMIDE | Authors: | Bone, R. | Deposit date: | 1991-10-04 | Release date: | 1993-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | X-Ray Crystal Structure of the HIV Protease Complex with L-700,417, an Inhibitor with Pseudo C2 Symmetry J.Am.Chem.Soc., 113, 1991
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