7KPY

Crystal structure of CBP bromodomain liganded with UMB298 (compound 23)

Summary for 7KPY

Entry DOI	10.2210/pdb7kpy/pdb
Descriptor	Histone acetyltransferase, 1,2-ETHANEDIOL, 2-[2-(3-chloranyl-4-methoxy-phenyl)ethyl]-~{N}-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine, ... (4 entities in total)
Functional Keywords	epigenetics, inhibitor, drug development, multi domain proteins, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28840.00
Authors	Schonbrunn, E.,Bikowitz, M. (deposition date: 2020-11-12, release date: 2021-05-19, Last modification date: 2023-10-18)
Primary citation	Muthengi, A.,Wimalasena, V.K.,Yosief, H.O.,Bikowitz, M.J.,Sigua, L.H.,Wang, T.,Li, D.,Gaieb, Z.,Dhawan, G.,Liu, S.,Erickson, J.,Amaro, R.E.,Schonbrunn, E.,Qi, J.,Zhang, W. Development of Dimethylisoxazole-Attached Imidazo[1,2- a ]pyridines as Potent and Selective CBP/P300 Inhibitors. J.Med.Chem., 64:5787-5801, 2021 Cited by PubMed: 33872011 DOI: 10.1021/acs.jmedchem.0c02232 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation