Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7KPY

Crystal structure of CBP bromodomain liganded with UMB298 (compound 23)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
B0004402molecular_functionhistone acetyltransferase activity
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue EDO A 1201
ChainResidue
AGLU1099
ALYS1139

site_idAC2
Number of Residues10
Detailsbinding site for residue WU1 A 1202
ChainResidue
APHE1177
AHOH1316
AHOH1356
APRO1110
AVAL1115
ALEU1120
AILE1122
AASN1168
AARG1173
AVAL1174

site_idAC3
Number of Residues2
Detailsbinding site for residue EDO B 1201
ChainResidue
BGLU1107
BASN1162

site_idAC4
Number of Residues4
Detailsbinding site for residue EDO B 1202
ChainResidue
BLYS1180
BGLU1183
BHOH1309
BHOH1371

site_idAC5
Number of Residues11
Detailsbinding site for residue WU1 B 1203
ChainResidue
BLEU1109
BPRO1110
BVAL1115
BILE1122
BASN1168
BARG1173
BVAL1174
BPHE1177
BHOH1307
BHOH1348
BHOH1354

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY
ChainResidueDetails
ASER1108-TYR1167

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues214
DetailsDomain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues92
DetailsRegion: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues36
DetailsRegion: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

PDB statisticsPDBj update infoContact PDBjnumon