1LYA

CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN

Summary for 1LYA

Entry DOI	10.2210/pdb1lya/pdb
Descriptor	CATHEPSIN D, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	lysosomal aspartic protease
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	75858.08
Authors	Baldwin, E.T.,Bhat, T.N.,Gulnik, S.,Erickson, J.W. (deposition date: 1993-04-22, release date: 1994-01-31, Last modification date: 2020-07-29)
Primary citation	Baldwin, E.T.,Bhat, T.N.,Gulnik, S.,Hosur, M.V.,Sowder 2nd., R.C.,Cachau, R.E.,Collins, J.,Silva, A.M.,Erickson, J.W. Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design. Proc.Natl.Acad.Sci.USA, 90:6796-6800, 1993 Cited by PubMed: 8393577 DOI: 10.1073/pnas.90.14.6796 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation