1LYA

CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN

Summary for 1LYA

DescriptorCATHEPSIN D, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... (6 entities in total)
Functional Keywordslysosomal aspartic protease
Biological sourceHomo sapiens (human)
Cellular locationLysosome P07339 P07339
Total number of polymer chains4
Total molecular weight75966.17
Authors
Baldwin, E.T.,Bhat, T.N.,Gulnik, S.,Erickson, J.W. (deposition date: 1993-04-22, release date: 1994-01-31, Last modification date: 2017-11-29)
Primary citation
Baldwin, E.T.,Bhat, T.N.,Gulnik, S.,Hosur, M.V.,Sowder 2nd., R.C.,Cachau, R.E.,Collins, J.,Silva, A.M.,Erickson, J.W.
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90:6796-6800, 1993
PubMed: 8393577 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.90.14.6796
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers61.3%8.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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