1LYA

CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	CATHEPSIN D	polymer	97	10688.9	2	UniProt (P07339) In PDB	Homo sapiens (human)
2	B, D	CATHEPSIN D	polymer	241	26270.2	2	UniProt (P07339) Pfam (PF00026) In PDB	Homo sapiens (human)
3	E, F	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G22573RC)
4	B, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5		water	water		18.0	46	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	73918.3
Branched	Number of molecules	2
	Total formula weight	1497.4
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	75858.1

*Water molecules are not included.