1PSA

STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR

Summary for 1PSA

Related PRD IDPRD_000378
DescriptorPEPSIN A, N-(ethoxycarbonyl)-L-leucyl-N-[(1R,2S,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-leucinamide (3 entities in total)
Functional Keywordsacid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSus scrofa (pig)
Cellular locationSecreted P00791
Total number of polymer chains2
Total molecular weight70110.54
Authors
Chen, L.,Abad-Zapatero, C. (deposition date: 1991-10-22, release date: 1994-01-31, Last modification date: 2017-11-29)
Primary citation
Chen, L.,Erickson, J.W.,Rydel, T.J.,Park, C.H.,Neidhart, D.,Luly, J.,Abad-Zapatero, C.
Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor.
Acta Crystallogr.,Sect.B, 48:476-488, 1992
PubMed: 1418819 (PDB entries with the same primary citation)
DOI: 10.1107/S0108768192001939
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers110.9%8.2%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report