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9HVP

Design, activity and 2.8 Angstroms crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease

Summary for 9HVP
Entry DOI10.2210/pdb9hvp/pdb
Related PRD IDPRD_000256
DescriptorHIV-1 Protease, benzyl [(1R,4S,6S,9R)-4,6-dibenzyl-5-hydroxy-1,9-bis(1-methylethyl)-2,8,11-trioxo-13-phenyl-12-oxa-3,7,10-triazatridec-1-yl]carbamate (3 entities in total)
Functional Keywordsacid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22398.46
Authors
Neidhart, D.J.,Erickson, J. (deposition date: 1990-11-06, release date: 1992-04-15, Last modification date: 2024-02-14)
Primary citationErickson, J.,Neidhart, D.J.,VanDrie, J.,Kempf, D.J.,Wang, X.C.,Norbeck, D.W.,Plattner, J.J.,Rittenhouse, J.W.,Turon, M.,Wideburg, N.
Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.
Science, 249:527-533, 1990
Cited by
PubMed: 2200122
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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