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1JQK
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BU of 1jqk by Molmil
Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum
Descriptor: FE (II) ION, FE(3)-NI(1)-S(4) CLUSTER, IRON/SULFUR CLUSTER, ...
Authors:Drennan, C.L, Heo, J, Sintchak, M.D, Schreiter, E, Ludden, P.W.
Deposit date:2001-08-07
Release date:2001-10-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase.
Proc.Natl.Acad.Sci.USA, 98, 2001
1BMT
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BU of 1bmt by Molmil
HOW A PROTEIN BINDS B12: A 3.O ANGSTROM X-RAY STRUCTURE OF THE B12-BINDING DOMAINS OF METHIONINE SYNTHASE
Descriptor: CO-METHYLCOBALAMIN, METHIONINE SYNTHASE
Authors:Drennan, C.L, Huang, S, Drummond, J.T, Matthews, R.G, Ludwig, M.L.
Deposit date:1994-09-02
Release date:1995-06-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase.
Science, 266, 1994
1D03
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BU of 1d03 by Molmil
REFINED STRUCTURES OF OXIDIZED FLAVODOXIN FROM ANACYSTIS NIDULANS
Descriptor: FLAVIN MONONUCLEOTIDE, FLAVODOXIN
Authors:Drennan, C.L, Pattridge, K.A, Weber, C.H, Metzger, A.L, Hoover, D.M, Ludwig, M.L.
Deposit date:1999-09-08
Release date:1999-12-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Refined structures of oxidized flavodoxin from Anacystis nidulans.
J.Mol.Biol., 294, 1999
1CZU
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BU of 1czu by Molmil
REFINED STRUCTURES OF OXIDIZED FLAVODOXIN FROM ANACYSTIS NIDULANS
Descriptor: FLAVIN MONONUCLEOTIDE, FLAVODOXIN
Authors:Drennan, C.L, Pattridge, K.A, Weber, C.H, Metzger, A.L, Hoover, D.M, Ludwig, M.L.
Deposit date:1999-09-07
Release date:1999-12-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Refined structures of oxidized flavodoxin from Anacystis nidulans.
J.Mol.Biol., 294, 1999
3SCG
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BU of 3scg by Molmil
Fe(II)-HppE with R-HPP
Descriptor: Epoxidase, FE (II) ION, [(2R)-2-hydroxypropyl]phosphonic acid
Authors:Drennan, C.L.
Deposit date:2011-06-07
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
3SCF
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BU of 3scf by Molmil
Fe(II)-HppE with S-HPP and NO
Descriptor: (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, Epoxidase, FE (II) ION, ...
Authors:Drennan, C.L.
Deposit date:2011-06-07
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
4XJK
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BU of 4xjk by Molmil
Crystal structure of Mn(II) Ca(II) Na(I) bound calprotectin
Descriptor: CALCIUM ION, MANGANESE (II) ION, Protein S100-A8, ...
Authors:Drennan, C.L, Bowman, S.E.J.
Deposit date:2015-01-08
Release date:2015-04-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis.
J.Am.Chem.Soc., 137, 2015
4J1X
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BU of 4j1x by Molmil
Crystal Structure of Fe(II)-HppE with alternative substrate (S)-1-HPP
Descriptor: Epoxidase, FE (II) ION, GLYCEROL, ...
Authors:Drennan, C.L, Dey, M.
Deposit date:2013-02-03
Release date:2013-04-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.
Nature, 496, 2013
4J1W
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BU of 4j1w by Molmil
Crystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPP
Descriptor: Epoxidase, FE (II) ION, GLYCEROL, ...
Authors:Drennan, C.L, Dey, M.
Deposit date:2013-02-03
Release date:2013-04-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction.
Nature, 496, 2013
4M7T
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BU of 4m7t by Molmil
Crystal structure of BtrN in complex with AdoMet and 2-DOIA
Descriptor: (1R,2S,3S,4R,5S)-5-aminocyclohexane-1,2,3,4-tetrol, BtrN, GLYCEROL, ...
Authors:Drennan, C.L, Goldman, P.J.
Deposit date:2013-08-12
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry.
Proc.Natl.Acad.Sci.USA, 110, 2013
3SCH
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BU of 3sch by Molmil
Co(II)-HppE with R-HPP
Descriptor: COBALT (II) ION, Epoxidase, [(2R)-2-hydroxypropyl]phosphonic acid
Authors:Drennan, C.L.
Deposit date:2011-06-07
Release date:2011-07-06
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
9O8U
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BU of 9o8u by Molmil
(1-methylalkyl)succinate synthase alpha-beta-gamma-delta complex with bound fumarate
Descriptor: 1-methyl alkyl succinate synthase subunit Mas E, 1-methyl alkyl succinate synthase subunit MasC, 1-methyl alkyl succinate synthase subunit MasD, ...
Authors:Andorfer, M.C, Drennan, C.L.
Deposit date:2025-04-16
Release date:2025-07-23
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural Basis for Anaerobic Alkane Activation by a Multi-Subunit Glycyl Radical Enzyme
To Be Published
5L2R
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BU of 5l2r by Molmil
Crystal structure of fumarate hydratase from Leishmania major
Descriptor: (2S)-2-hydroxybutanedioic acid, DI(HYDROXYETHYL)ETHER, Fumarate hydratase, ...
Authors:Feliciano, P.R, Drennan, C.L, Nonato, M.C.
Deposit date:2016-08-02
Release date:2016-08-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EXD
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BU of 5exd by Molmil
Crystal structure of oxalate oxidoreductase from Moorella thermoacetica bound with carboxy-di-oxido-methyl-TPP (COOM-TPP) intermediate
Descriptor: IRON/SULFUR CLUSTER, MAGNESIUM ION, Oxalate oxidoreductase subunit alpha, ...
Authors:Gibson, M.I, Chen, P.Y.-T, Drennan, C.L.
Deposit date:2015-11-23
Release date:2015-12-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 113, 2016
6OUW
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BU of 6ouw by Molmil
1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with enamine intermediate bound
Descriptor: 1-deoxy-D-xylulose-5-phosphate synthase, 2-ACETYL-THIAMINE DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Chen, P.Y.-T, Drennan, C.L.
Deposit date:2019-05-05
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.
J.Biol.Chem., 294, 2019
4M7S
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BU of 4m7s by Molmil
Crystal structure of SeMet BtrN in an OPEN conformation
Descriptor: BtrN, GLYCEROL, IMIDAZOLE, ...
Authors:Goldman, P.J, Drennan, C.L.
Deposit date:2013-08-12
Release date:2013-10-02
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.022 Å)
Cite:X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry.
Proc.Natl.Acad.Sci.USA, 110, 2013
8DPB
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BU of 8dpb by Molmil
MeaB in complex with the cobalamin-binding domain of its target mutase with GMPPCP bound
Descriptor: GLYCEROL, MAGNESIUM ION, Methylmalonyl-CoA mutase accessory protein, ...
Authors:Vaccaro, F.A, Born, D.A, Drennan, C.L.
Deposit date:2022-07-15
Release date:2023-03-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery.
Proc.Natl.Acad.Sci.USA, 120, 2023
5W1F
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BU of 5w1f by Molmil
Crystal structure of Ni(II)- and Ca(II)-bound human calprotectin
Descriptor: CALCIUM ION, NICKEL (II) ION, Protein S100-A8, ...
Authors:Nakashige, T.G, Drennan, C.L, Nolan, E.M.
Deposit date:2017-06-03
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Nickel Sequestration by the Host-Defense Protein Human Calprotectin.
J. Am. Chem. Soc., 139, 2017
7KQ4
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BU of 7kq4 by Molmil
Structure of isethionate sulfite-lyase from Bilophila wadsworthia with glycerol bound
Descriptor: GLYCEROL, Isethionate sulfite-lyase
Authors:Dawson, C.D, Backman, L.R.F, Drennan, C.L.
Deposit date:2020-11-13
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.261 Å)
Cite:Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase.
Cell Chem Biol, 28, 2021
7KQ3
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BU of 7kq3 by Molmil
Structure of isethionate sulfite-lyase from Bilophila wadsworthia with substrate isethionate bound
Descriptor: 2-hydroxyethylsulfonic acid, Isethionate sulfite-lyase
Authors:Dawson, C.D, Backman, L.R.F, Drennan, C.L.
Deposit date:2020-11-13
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.688 Å)
Cite:Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase.
Cell Chem Biol, 28, 2021
6ONC
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BU of 6onc by Molmil
Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase produced without CooC, as-isolated
Descriptor: CHLORIDE ION, Carbon monoxide dehydrogenase, FE (III) ION, ...
Authors:Wittenborn, E.C, Cohen, S.E, Drennan, C.L.
Deposit date:2019-04-21
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase.
J.Biol.Chem., 294, 2019
6ONS
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BU of 6ons by Molmil
Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase with the D-cluster ligating cysteines mutated to alanines, coexpressed with CooC, as-isolated
Descriptor: Carbon monoxide dehydrogenase, FE(4)-NI(1)-S(4) CLUSTER, IRON/SULFUR CLUSTER
Authors:Cohen, S.E, Wittenborn, E.C, Drennan, C.L.
Deposit date:2019-04-22
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.485 Å)
Cite:Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase.
J.Biol.Chem., 294, 2019
6OWR
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BU of 6owr by Molmil
NMR solution structure of YfiD
Descriptor: Autonomous glycyl radical cofactor
Authors:Bowman, S.E.J, Drennan, C.L.
Deposit date:2019-05-10
Release date:2019-07-10
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme.
J.Biol.Inorg.Chem., 24, 2019
2R0P
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BU of 2r0p by Molmil
K252c-soaked RebC
Descriptor: 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Ryan, K.S, Drennan, C.L.
Deposit date:2007-08-20
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QM7
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BU of 2qm7 by Molmil
MeaB, A Bacterial Homolog of MMAA, Bound to GDP
Descriptor: GTPase/ATPase, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION
Authors:Hubbard, P.A, Padovani, D, Labunska, T, Mahlstedt, S.A, Banerjee, R, Drennan, C.L.
Deposit date:2007-07-14
Release date:2007-08-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria.
J.Biol.Chem., 282, 2007

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