5YX6
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5WYE
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8FTQ
| Crystal structure of hRpn13 Pru domain in complex with Ubiquitin and XL44 | Descriptor: | N-(3-{[(3R)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl}phenyl)-4-methoxybenzamide, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | Authors: | Walters, K.J, Lu, X, Chandravanshi, M. | Deposit date: | 2023-01-13 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nat Commun, 15, 2024
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5SZU
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5T02
| Structural characterisation of mutant Asp39Ala of thioesterase (NmACH) from Neisseria meningitidis | Descriptor: | Acyl-CoA hydrolase, CHLORIDE ION, COENZYME A, ... | Authors: | Khandokar, Y.B, Srivastava, P, Forwood, J.K. | Deposit date: | 2016-08-15 | Release date: | 2016-09-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase. J. Biol. Chem., 292, 2017
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5SZZ
| Novel Structural Insights into GDP-Mediated Regulation of Acyl-CoA Thioesterases | Descriptor: | Acyl-CoA hydrolase, CHLORIDE ION, COENZYME A, ... | Authors: | Khandokar, Y.B, Srivastava, P, Forwood, J.K. | Deposit date: | 2016-08-15 | Release date: | 2016-09-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase. J. Biol. Chem., 292, 2017
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5SZV
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5SZY
| Novel Structural Insights into GDP-Mediated Regulation of Acyl-CoA Thioesterases | Descriptor: | Acyl-CoA hydrolase, CHLORIDE ION, COENZYME A, ... | Authors: | Khandokar, Y.B, Srivastava, P, Forwood, J.K. | Deposit date: | 2016-08-15 | Release date: | 2016-09-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase. J. Biol. Chem., 292, 2017
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5V3A
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7KXI
| Structure of XL5-ligated hRpn13 Pru domain | Descriptor: | 2-{[(2S)-2-cyano-3-{3-[(4-methylbenzene-1-carbonyl)amino]phenyl}propanoyl]amino}benzoic acid, Proteasomal ubiquitin receptor ADRM1 | Authors: | Lu, X, Walters, K.J. | Deposit date: | 2020-12-03 | Release date: | 2021-12-15 | Last modified: | 2021-12-29 | Method: | SOLUTION NMR | Cite: | Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma. Nat Commun, 12, 2021
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7WVL
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5DNI
| Crystal structure of Methanocaldococcus jannaschii Fumarate hydratase beta subunit | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Jayaraman, V, Kunala, J, Balaram, H. | Deposit date: | 2015-09-10 | Release date: | 2016-09-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Revisiting the Burden Borne by Fumarase: Enzymatic Hydration of an Olefin. Biochemistry, 62, 2023
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7D40
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7D95
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3MJW
| PI3 Kinase gamma with a benzofuranone inhibitor | Descriptor: | (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Authors: | Bard, J, Svenson, K. | Deposit date: | 2010-04-13 | Release date: | 2010-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | 5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer. Bioorg.Med.Chem.Lett., 20, 2010
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7D96
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7D97
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2IVX
| Crystal structure of human cyclin T2 at 1.8 A resolution | Descriptor: | 1,2-ETHANEDIOL, CYCLIN-T2 | Authors: | Debreczeni, J.E, Bullock, A.N, Fedorov, O, Savitsky, P, Berridge, G, Das, S, Pike, A.C.W, Turnbull, A, Ugochukwu, E, Papagrigoriou, E, Gorrec, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, von Delft, F, Knapp, S. | Deposit date: | 2006-06-21 | Release date: | 2006-07-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. EMBO J., 27, 2008
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5XMB
| Mycobacterium tuberculosis Pantothenate kinase mutant F247A | Descriptor: | Pantothenate kinase, SULFATE ION | Authors: | Paul, A, Kumar, P, Surolia, A, Vijayan, M. | Deposit date: | 2017-05-13 | Release date: | 2018-05-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Biochemical and structural studies of mutants indicate concerted movement of the dimer interface and ligand-binding region of Mycobacterium tuberculosis pantothenate kinase Acta Crystallogr F Struct Biol Commun, 73, 2017
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2QEP
| Crystal structure of the D1 domain of PTPRN2 (IA2beta) | Descriptor: | CHLORIDE ION, Receptor-type tyrosine-protein phosphatase N2 | Authors: | Ugochukwu, E, Barr, A, Alfano, I, Berridge, G, Burgess-Brown, N, Das, S, Fedorov, O, King, O, Niesen, F, Watt, S, Savitsky, P, Salah, E, Pike, A.C.W, Bunkoczi, G, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C.H, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-26 | Release date: | 2007-07-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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2B49
| Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase, non-receptor Type 3 | Descriptor: | protein tyrosine phosphatase, non-receptor type 3 | Authors: | Ugochukwu, E, Arrowsmith, C, Barr, A, Bunkoczi, G, Das, S, Debreczeni, J, Edwards, A, Eswaran, J, Knapp, S, Sundstrom, M, Turnbull, A, von Delft, F, Weigelt, J, Structural Genomics Consortium (SGC) | Deposit date: | 2005-09-23 | Release date: | 2005-10-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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2AHS
| Crystal Structure of the Catalytic Domain of Human Tyrosine Receptor Phosphatase Beta | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Receptor-type tyrosine-protein phosphatase beta, ... | Authors: | Ugochukwu, E, Eswaran, J, Barr, A, Gileadi, O, Sobott, F, Burgess, N, Ball, L, Bray, J, von Delft, F, Debreczeni, J, Bunkoczi, G, Turnbull, A, Das, S, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2005-07-28 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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2I75
| Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4) | Descriptor: | SULFATE ION, Tyrosine-protein phosphatase non-receptor type 4 | Authors: | Ugochukwu, E, Barr, A, Savitsky, P, Burgess, N, Das, S, Turnbull, A, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-08-30 | Release date: | 2006-10-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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2JJD
| Protein Tyrosine Phosphatase, Receptor Type, E isoform | Descriptor: | CHLORIDE ION, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON | Authors: | Elkins, J.M, Ugochukwu, E, Alfano, I, Barr, A.J, Bunkoczi, G, King, O.N.F, Filippakopoulos, P, Savitsky, P, Salah, E, Pike, A, Johansson, C, Das, S, Burgess-Brown, N.A, Gileadi, O, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S. | Deposit date: | 2008-03-31 | Release date: | 2008-04-08 | Last modified: | 2012-06-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.), 136, 2009
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2PA5
| Crystal structure of human protein tyrosine phosphatase PTPN9 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, THIOCYANATE ION, ... | Authors: | Ugochukwu, E, Barr, A, Pike, A.C.W, Savitsky, P, Papagrigoriou, E, Turnbull, A, Uppenberg, J, Bunkoczi, G, Salah, E, Das, S, von Delft, F, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-03-27 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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