3X2W
| Michaelis complex of cAMP-dependent Protein Kinase Catalytic Subunit | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, MAGNESIUM ION, ... | 著者 | Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. | 登録日 | 2015-01-02 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
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3X2V
| Michaelis-like complex of cAMP-dependent Protein Kinase Catalytic Subunit | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, MAGNESIUM ION, ... | 著者 | Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. | 登録日 | 2015-01-02 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
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3X2U
| Michaelis-like initial complex of cAMP-dependent Protein Kinase Catalytic Subunit. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Substrate Peptide, ... | 著者 | Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. | 登録日 | 2015-01-02 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
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5YRS
| X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate | 分子名称: | PROTEASE, RT-RH oligopeprtide | 著者 | Das, A, Mahale, S, Prashar, V, Bihani, S, Ferrer, J.-L, Hosur, M.V. | 登録日 | 2017-11-10 | 公開日 | 2018-03-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | X-ray snapshot of HIV-1 protease in action: observation of tetrahedral intermediate and short ionic hydrogen bond SIHB with catalytic aspartate. J. Am. Chem. Soc., 132, 2010
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5DN7
| Crescerin uses a TOG domain array to regulate microtubules in the primary cilium | 分子名称: | Protein FAM179B | 著者 | Das, A, Dickinson, D.J, Wood, C.C, Goldstein, B, Slep, K.C. | 登録日 | 2015-09-09 | 公開日 | 2015-09-23 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Mol.Biol.Cell, 26, 2015
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7L3L
| Structure of TRAF5 and TRAF6 RING Hetero dimer | 分子名称: | TNF receptor-associated factor 5, TNF receptor-associated factor 6, ZINC ION | 著者 | Das, A, Middleton, A.J, Padala, P, Day, C.L. | 登録日 | 2020-12-17 | 公開日 | 2021-02-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The structure and ubiquitin binding properties of TRAF RING heterodimers. J.Mol.Biol., 2021
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6WC0
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6WBR
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2NPH
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6KMP
| 100K X-ray structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with tetrahedral intermediate mimic KVS-1 | 分子名称: | N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide, Protease | 著者 | Das, A, Kovalevsky, A. | 登録日 | 2019-07-31 | 公開日 | 2020-07-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design. Acs Omega, 5, 2020
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4O22
| Binary complex of metal-free PKAc with SP20. | 分子名称: | Phosphorylated peptide pSP20., cAMP-dependent protein kinase catalytic subunit alpha. | 著者 | Das, A, Kovalevsky, A.Y, Gerlits, O, Langan, P, Heller, W.T, Keshwani, M, Taylor, S.S. | 登録日 | 2013-12-16 | 公開日 | 2014-05-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
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4O21
| Product complex of metal-free PKAc, ATP-gamma-S and SP20. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Thio-phosphorylated peptide pSP20, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Das, A, Kovalevsky, A.Y, Gerlits, O, Langan, P, Heller, W.T, Keshwani, M, Taylor, S. | 登録日 | 2013-12-16 | 公開日 | 2014-05-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
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8D2L
| Structure of Acidothermus cellulolyticus Cas9 ternary complex (Cleavage Intermediate 1) | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*GP*A)-3'), ... | 著者 | Rai, J, Das, A, Li, H. | 登録日 | 2022-05-30 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.21 Å) | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9 Nat Catal, 6, 2023
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8D2K
| Structure of Acidothermus cellulolyticus Cas9 ternary complex (Cleavage Intermediate 2) | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*GP*A)-3'), ... | 著者 | Rai, J, Das, A, Li, H. | 登録日 | 2022-05-30 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9 Nat Catal, 6, 2023
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8D2N
| Structure of Acidothermus cellulolyticus Cas9 ternary complex (Pre-cleavage) | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*TP*AP*CP*AP*CP*CP*AP*AP*GP*CP*T)-3'), ... | 著者 | Rai, J, Das, A, Li, H. | 登録日 | 2022-05-30 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9 Nat Catal, 6, 2023
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8D2Q
| Structure of Acidothermus cellulolyticus Cas9 ternary complex (Post-cleavage 1) | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*TP*AP*CP*AP*CP*CP*AP*AP*GP*CP*T)-3'), ... | 著者 | Rai, J, Das, A, Li, H. | 登録日 | 2022-05-30 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9 Nat Catal, 6, 2023
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8D2P
| Structure of Acidothermus cellulolyticus Cas9 ternary complex (Target bound) | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA target strand (5'-D(P*CP*CP*AP*GP*GP*AP*TP*CP*TP*TP*GP*CP*CP*AP*TP*CP*CP*TP*AP*CP*CP*TP*CP*T)-3'), ... | 著者 | Rai, J, Das, A, Li, H. | 登録日 | 2022-05-30 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9 Nat Catal, 6, 2023
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8D2O
| Structure of Acidothermus cellulolyticus Cas9 ternary complex (Post-cleavage 2) | 分子名称: | CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*AP*TP*AP*CP*AP*CP*CP*AP*AP*GP*CP*T)-3'), ... | 著者 | Rai, J, Das, A, Li, H. | 登録日 | 2022-05-30 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Coupled catalytic states and the role of metal coordination in Cas9 Nat Catal, 6, 2023
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8FAI
| Cryo-EM structure of the Agrobacterium T-pilus | 分子名称: | (7Z,19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacos-7-en-19-yl (9Z)-octadec-9-enoate, Protein virB2 | 著者 | Kreida, S, Narita, A, Johnson, M.D, Tocheva, E.I, Das, A, Jensen, G.J, Ghosal, D. | 登録日 | 2022-11-27 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly. Structure, 31, 2023
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6PU8
| Room temperature X-ray structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with tetrahedral intermediate of keto-darunavir | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3,3-dihydroxy-1-phenylbutan-2-yl]carbamate, HIV-1 protease | 著者 | Kovalevsky, A, Das, A. | 登録日 | 2019-07-17 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design. Acs Omega, 5, 2020
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6PTP
| Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with tetrahedral intermediate mimic KVS-1 | 分子名称: | HIV-1 Protease, N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide | 著者 | Kovalevsky, A, Das, A. | 登録日 | 2019-07-16 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-25 | 実験手法 | NEUTRON DIFFRACTION (1.85 Å), X-RAY DIFFRACTION | 主引用文献 | Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design. Acs Omega, 5, 2020
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4XW6
| X-ray structure of PKAc with ADP, free phosphate ion, CP20, magnesium ions | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Gerlits, O, Tian, J, Das, A, Taylor, S, Langan, P, Heller, T.W, Kovalevsky, A. | 登録日 | 2015-01-28 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J.Biol.Chem., 290, 2015
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4XW5
| X-ray structure of PKAc with ATP, CP20, calcium ions | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Gerlits, O, Tian, J, Das, A, Taylor, S, Langan, P, Heller, T.W, Kovalevsky, A. | 登録日 | 2015-01-28 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J.Biol.Chem., 290, 2015
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4XW4
| X-ray structure of PKAc with AMPPNP, SP20, calcium ions | 分子名称: | CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Gerlits, O, Tian, J, Das, A, Taylor, S, Langan, P, Heller, T.W, Kovalevsky, A. | 登録日 | 2015-01-28 | 公開日 | 2015-05-06 | 最終更新日 | 2015-07-01 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J.Biol.Chem., 290, 2015
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1JO1
| N7-Guanine Adduct of 2,7-diaminomitosene with DNA | 分子名称: | 5'-D(*GP*TP*GP*(DAJ)GP*TP*AP*TP*AP*CP*CP*AP*C)-3', DECARBAMOYL-2,7-DIAMINOMITOSENE | 著者 | Subramaniam, G, Paz, M.M, Kumar, G.S, Das, A, Palom, Y, Clement, C.C, Patel, D.J, Tomasz, M. | 登録日 | 2001-07-26 | 公開日 | 2001-09-12 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity. Biochemistry, 40, 2001
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