1I50
 
 | | RNA POLYMERASE II CRYSTAL FORM II AT 2.8 A RESOLUTION | | Descriptor: | DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.2KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.5KD POLYPEPTIDE, ... | | Authors: | Cramer, P, Bushnell, D.A, Kornberg, R.D. | | Deposit date: | 2001-02-23 | | Release date: | 2001-04-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.
Science, 292, 2001
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1I3Q
 | | RNA POLYMERASE II CRYSTAL FORM I AT 3.1 A RESOLUTION | | Descriptor: | DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.2KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.5KD POLYPEPTIDE, ... | | Authors: | Cramer, P, Bushnell, D.A, Kornberg, R.D. | | Deposit date: | 2001-02-15 | | Release date: | 2001-04-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution.
Science, 292, 2001
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1A3Q
 | | HUMAN NF-KAPPA-B P52 BOUND TO DNA | | Descriptor: | DNA (5'-D(*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*AP*TP*TP*CP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B P52) | | Authors: | Cramer, P, Larson, C.J, Verdine, G.L, Muller, C.W. | | Deposit date: | 1998-01-23 | | Release date: | 1998-06-11 | | Last modified: | 2026-03-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution.
EMBO J., 16, 1997
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1BVO
 | | DORSAL HOMOLOGUE GAMBIF1 BOUND TO DNA | | Descriptor: | DNA DUPLEX, TRANSCRIPTION FACTOR GAMBIF1 | | Authors: | Cramer, P, Varrot, A, Barillas-Mury, C, Kafatos, F.C, Mueller, C.W. | | Deposit date: | 1998-09-16 | | Release date: | 1999-07-12 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA.
Structure Fold.Des., 7, 1999
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1Y1Y
 | | RNA Polymerase II-TFIIS-DNA/RNA complex | | Descriptor: | 5'-D(P*TP*AP*CP*GP*CP*CP*T)-3', 5'-R(P*AP*GP*GP*C)-3', DNA-directed RNA polymerase II 13.6 kDa polypeptide, ... | | Authors: | Cramer, P, Kettenberger, H, Armache, K.-J. | | Deposit date: | 2004-11-19 | | Release date: | 2004-12-28 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS.
Mol.Cell, 16, 2004
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1Y1W
 | | Complete RNA Polymerase II elongation complex | | Descriptor: | 5'-D(*AP*AP*GP*TP*AP*CP*T)-3', 5'-D(P*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*AP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | | Authors: | Cramer, P, Kettenberger, H, Armache, K.-J. | | Deposit date: | 2004-11-19 | | Release date: | 2005-01-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
Mol.Cell, 16, 2004
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9I81
 | | SARS-CoV-2 RdRp bound to a stack of three HeE1-2Tyr molecules | | Descriptor: | N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Kabinger, F, Doze, V, Schmitzova, J, Lidschreiber, M, Dienemann, C, Cramer, P. | | Deposit date: | 2025-02-04 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural basis of SARS-CoV-2 polymerase inhibition by nonnucleoside inhibitor HeE1-2Tyr.
Proc.Natl.Acad.Sci.USA, 122, 2025
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1I6H
 | | RNA POLYMERASE II ELONGATION COMPLEX | | Descriptor: | 5'-D(P*AP*AP*AP*TP*GP*CP*CP*TP*GP*GP*TP*CP*T)-3', 5'-R(P*GP*AP*CP*CP*AP*GP*GP*CP*A)-3', DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE, ... | | Authors: | Gnatt, A.L, Cramer, P, Kornberg, R.D. | | Deposit date: | 2001-03-02 | | Release date: | 2001-04-23 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.
Science, 292, 2001
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4YM7
 | | RNA polymerase I structure with an alternative dimer hinge | | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | Authors: | Kostrewa, D, Kuhn, C.-D, Engel, C, Cramer, P. | | Deposit date: | 2015-03-06 | | Release date: | 2015-09-09 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (5.5 Å) | | Cite: | An alternative RNA polymerase I structure reveals a dimer hinge.
Acta Crystallogr.,Sect.D, 71, 2015
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6I84
 | | Structure of transcribing RNA polymerase II-nucleosome complex | | Descriptor: | DNA (158-MER), DNA (170-MER), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Farnung, L, Vos, S.M, Cramer, P. | | Deposit date: | 2018-11-19 | | Release date: | 2019-01-02 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure of transcribing RNA polymerase II-nucleosome complex.
Nat Commun, 9, 2018
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5CE7
 | | Structure of a non-canonical CID of Ctk3 | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CTD kinase subunit gamma | | Authors: | Muehlbacher, W, Mayer, A, Sun, M, Remmert, M, Cheung, A.C, Niesser, J, Soeding, J, Cramer, P. | | Deposit date: | 2015-07-06 | | Release date: | 2015-08-05 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.
Proteins, 83, 2015
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4V1N
 | | Architecture of the RNA polymerase II-Mediator core transcription initiation complex | | Descriptor: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | | Authors: | Plaschka, C, Lariviere, L, Wenzeck, L, Hemann, M, Tegunov, D, Petrotchenko, E.V, Borchers, C.H, Baumeister, W, Herzog, F, Villa, E, Cramer, P. | | Deposit date: | 2014-09-29 | | Release date: | 2015-02-04 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Architecture of the RNA Polymerase II-Mediator Core Initiation Complex.
Nature, 518, 2015
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4V1O
 | | Architecture of the RNA polymerase II-Mediator core transcription initiation complex | | Descriptor: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | | Authors: | Plaschka, C, Lariviere, L, Wenzeck, L, Hemann, M, Tegunov, D, Petrotchenko, E.V, Borchers, C.H, Baumeister, W, Herzog, F, Villa, E, Cramer, P. | | Deposit date: | 2014-09-29 | | Release date: | 2015-02-04 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (9.7 Å) | | Cite: | Architecture of the RNA Polymerase II-Mediator Core Initiation Complex.
Nature, 518, 2015
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1PQV
 | | RNA polymerase II-TFIIS complex | | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 14.2 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, ... | | Authors: | Kettenberger, H, Armache, K.-J, Cramer, P. | | Deposit date: | 2003-06-19 | | Release date: | 2003-08-19 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage
Cell(Cambridge,Mass.), 114, 2003
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9RTT
 | | Activated Elongation Complex with IWS1 and ELOF1 | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Walshe, J.L, Cramer, P. | | Deposit date: | 2025-07-03 | | Release date: | 2025-09-03 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | IWS1 positions downstream DNA to globally stimulate Pol II elongation.
Nat Commun, 16, 2025
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1NT9
 | | Complete 12-subunit RNA polymerase II | | Descriptor: | DNA-DIRECTED RNA POLYMERASE II 13.6 KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 19 KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT, ... | | Authors: | Armache, K.-J, Kettenberger, H, Cramer, P. | | Deposit date: | 2003-01-29 | | Release date: | 2003-04-22 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Architecture of initiation-competent 12-subunit RNA polymerase II
Proc.Natl.Acad.Sci.USA, 100, 2003
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3T2N
 | | Human hepsin protease in complex with the Fab fragment of an inhibitory antibody | | Descriptor: | Antibody, Fab fragment, Heavy Chain, ... | | Authors: | Koschubs, T, Dengl, S, Duerr, H, Kaluza, K, Georges, G, Hartl, C, Jennewein, S, Lanzendoerfer, M, Auer, J, Stern, A, Huang, K.-S, Kostrewa, D, Ries, S, Hansen, S, Kohnert, U, Cramer, P, Mundigl, O. | | Deposit date: | 2011-07-22 | | Release date: | 2011-12-28 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Allosteric antibody inhibition of human hepsin protease.
Biochem.J., 442, 2012
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3SPA
 | | Crystal Structure of Human Mitochondrial RNA Polymerase | | Descriptor: | CHLORIDE ION, DNA-directed RNA polymerase, mitochondrial, ... | | Authors: | Ringel, R, Sologub, M, Morozov, Y.I, Litonin, D, Cramer, P, Temiakov, D. | | Deposit date: | 2011-07-01 | | Release date: | 2011-09-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of human mitochondrial RNA polymerase
Nature, 478, 2011
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9RZC
 | | State 3 MAP 1 SETD2 bound to distal H3 of upstream nucleosome | | Descriptor: | FACT complex subunit SPT16, Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | Walshe, J.L, Ochmann, M, Dienemann, C, Cramer, P. | | Deposit date: | 2025-07-15 | | Release date: | 2025-09-24 | | Last modified: | 2025-11-12 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Molecular mechanism of co-transcriptional H3K36 methylation by SETD2.
Nat Commun, 16, 2025
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9RTN
 | | State 2 MAP 2 SPT6 with SETD2 | | Descriptor: | DNA-directed RNA polymerase II subunit RPB7, Histone-lysine N-methyltransferase SETD2, RNA polymerase II subunit D, ... | | Authors: | Walshe, J.L, Ochmann, M, Dienemann, C, Cramer, P. | | Deposit date: | 2025-07-03 | | Release date: | 2025-09-24 | | Last modified: | 2025-11-12 | | Method: | ELECTRON MICROSCOPY (3.82 Å) | | Cite: | Molecular mechanism of co-transcriptional H3K36 methylation by SETD2.
Nat Commun, 16, 2025
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9RZD
 | | State 3 MAP 2 SPT6 with SETD2 | | Descriptor: | DNA-directed RNA polymerase II subunit RPB7, Histone-lysine N-methyltransferase SETD2, RNA polymerase II subunit D, ... | | Authors: | Walshe, J.L, Ochmann, M, Dienemann, C, Cramer, P. | | Deposit date: | 2025-07-15 | | Release date: | 2025-09-24 | | Last modified: | 2025-11-12 | | Method: | ELECTRON MICROSCOPY (3.69 Å) | | Cite: | Molecular mechanism of co-transcriptional H3K36 methylation by SETD2.
Nat Commun, 16, 2025
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9S0U
 | | State 3 MAP 3 RNA Pol II activated elongation complex with SETD2 bound to distal upstream H3 | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Walshe, J.L, Ochmann, M, Dienemann, C, Cramer, P. | | Deposit date: | 2025-07-17 | | Release date: | 2025-09-24 | | Last modified: | 2025-11-12 | | Method: | ELECTRON MICROSCOPY (6.72 Å) | | Cite: | Molecular mechanism of co-transcriptional H3K36 methylation by SETD2.
Nat Commun, 16, 2025
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9S3G
 | | State 1 MAP3 RNA Pol II activated elongation complex with SETD2 and upstream hexasome | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Walshe, J.L, Ochmann, M, Dienemann, C, Cramer, P. | | Deposit date: | 2025-07-24 | | Release date: | 2025-11-12 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | Molecular mechanism of co-transcriptional H3K36 methylation by SETD2.
Nat Commun, 16, 2025
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3TJ1
 | | Crystal Structure of RNA Polymerase I Transcription Initiation Factor Rrn3 | | Descriptor: | RNA polymerase I-specific transcription initiation factor RRN3 | | Authors: | Blattner, C, Jennebach, S, Herzog, F, Mayer, A, Cheung, A.C.M, Witte, G, Lorenzen, K, Hopfner, K.-P, Heck, A.J.R, Aebersold, R, Cramer, P. | | Deposit date: | 2011-08-23 | | Release date: | 2011-09-28 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.
Genes Dev., 25, 2011
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7ZXE
 | | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) | | Descriptor: | Non-template strand, TATA-box-binding protein, Template strand, ... | | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | | Deposit date: | 2022-05-20 | | Release date: | 2022-11-30 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Nat.Struct.Mol.Biol., 29, 2022
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