8BQ2
| CryoEM structure of the pre-synaptic RAD51 nucleoprotein filament in the presence of ATP and Ca2+ | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ... | 著者 | Appleby, R, Bollschweiler, D, Pellegrini, L. | 登録日 | 2022-11-18 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly. Iscience, 26, 2023
|
|
8BHY
| |
8BHV
| |
8BH3
| |
8BHR
| GABA-A receptor a5 homomer - a5V3 - RO7015738 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]-~{N}-[(2~{S})-1-oxidanylpentan-2-yl]pyridine-3-carboxamide, Gamma-aminobutyric acid receptor subunit alpha-5 | 著者 | Miller, P.S, Malinauskas, T.M, Kasaragod, V.B. | 登録日 | 2022-10-31 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
|
|
8BHQ
| GABA-A receptor a5 homomer - a5V3 - RO7172670 | 分子名称: | 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5 | 著者 | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Kasaragod, V.B. | 登録日 | 2022-10-31 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
|
|
8BGI
| GABA-A receptor a5 homomer - a5V1 - Flumazenil | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, Pregnanolone, ... | 著者 | Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R. | 登録日 | 2022-10-27 | 公開日 | 2023-11-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
|
|
8BHG
| GABA-A receptor a5 heteromer - a5V2 - Bretazenil | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bretazenil, DECYL-BETA-D-MALTOPYRANOSIDE, ... | 著者 | Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R. | 登録日 | 2022-10-31 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
|
|
3SP8
| Crystal structure of NK2 in complex with fractionated Heparin DP10 | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Recacha, R, Mulloy, B, Gherardi, E. | 登録日 | 2011-07-01 | 公開日 | 2012-07-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Crystal structure of NK2 in complex with fractionated Heparin DP10 TO BE PUBLISHED
|
|
4KG0
| Crystal structure of the drosophila melanogaster neuralized-nhr1 domain | 分子名称: | MAGNESIUM ION, Protein neuralized | 著者 | Gupta, D, Ehebauer, M.T, Chirgadze, D.Y, Bolanos-Garcia, V.M, Blundell, T.L. | 登録日 | 2013-04-28 | 公開日 | 2014-01-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure, biochemical and biophysical characterisation of NHR1 domain of E3 Ubiquitin ligase neutralized Advances in Enzyme Research, 1, 2013
|
|
2C45
| |
5DFB
| Crystal structure of BRD2(BD2) mutant W370F in the free form | 分子名称: | Bromodomain-containing protein 2, GLYCEROL, NICKEL (II) ION, ... | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2015-08-26 | 公開日 | 2015-11-11 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. J.Med.Chem., 59, 2016
|
|
5DFD
| Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound | 分子名称: | Bromodomain-containing protein 2, GLYCEROL, methyl [(4S)-6-(1H-indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2015-08-26 | 公開日 | 2015-11-11 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. J.Med.Chem., 59, 2016
|
|
5DFC
| Crystal structure of BRD2(BD2) W370F mutant with ligand I-BET 762 bound | 分子名称: | 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, Bromodomain-containing protein 2, GLYCEROL, ... | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2015-08-26 | 公開日 | 2015-11-11 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. J.Med.Chem., 59, 2016
|
|
4QEU
| Crystal structure of BRD2(BD2) mutant in free form | 分子名称: | ACETATE ION, Bromodomain-containing protein 2, GLYCEROL | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2014-05-19 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science, 346, 2014
|
|
4QF3
| Crystal structure of human BAZ2B PHD zinc finger in the free form | 分子名称: | Bromodomain adjacent to zinc finger domain protein 2B, ZINC ION | 著者 | Tallant, C, Van Molle, I, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2014-05-19 | 公開日 | 2014-07-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure, 23, 2015
|
|
4QEW
| Crystal structure of BRD2(BD2) mutant with ligand ET bound (METHYL (2R)- 2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1, 4]BENZODIAZEPIN-4-YL]BUTANOATE) | 分子名称: | Bromodomain-containing protein 2, GLYCEROL, NICKEL (II) ION, ... | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2014-05-19 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science, 346, 2014
|
|
4QF2
| Crystal structure of human BAZ2A PHD zinc finger in the free form | 分子名称: | Bromodomain adjacent to zinc finger domain protein 2A, GLYCEROL, PHOSPHATE ION, ... | 著者 | Tallant, C, Overvoorde, L, Van Molle, I, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2014-05-19 | 公開日 | 2014-07-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure, 23, 2015
|
|
4QEV
| Crystal structure of BRD2(BD2) mutant with ligand ME bound (METHYL (2R)- 2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1, 4]BENZODIAZEPIN-4-YL]PROPANOATE) | 分子名称: | Bromodomain-containing protein 2, GLYCEROL, NICKEL (II) ION, ... | 著者 | Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. | 登録日 | 2014-05-19 | 公開日 | 2014-10-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science, 346, 2014
|
|