5DFD

Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound

Summary for 5DFD

Entry DOI	10.2210/pdb5dfd/pdb
Descriptor	Bromodomain-containing protein 2, methyl [(4S)-6-(1H-indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate, GLYCEROL, ... (4 entities in total)
Functional Keywords	transcription factors, bet bromodomains, protein mutation engineering, molecular probes, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P25440
Total number of polymer chains	1
Total formula weight	13843.91
Authors	Tallant, C.,Baud, M.,Lin-Shiao, E.,Chirgadze, D.Y.,Ciulli, A. (deposition date: 2015-08-26, release date: 2015-11-11, Last modification date: 2024-01-10)
Primary citation	Baud, M.G.,Lin-Shiao, E.,Zengerle, M.,Tallant, C.,Ciulli, A. New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. J.Med.Chem., 59:1492-1500, 2016 Cited by PubMed: 26367539 DOI: 10.1021/acs.jmedchem.5b01135 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation