4QEW

Crystal structure of BRD2(BD2) mutant with ligand ET bound (METHYL (2R)- 2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1, 4]BENZODIAZEPIN-4-YL]BUTANOATE)

Summary for 4QEW

• Entry DOI: 10.2210/pdb4qew/pdb
• Related: 4QEN 4QEO
• Descriptor: Bromodomain-containing protein 2, GLYCEROL, NONAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: bromodomain-containing protein 2, kiaa9001, ring3, transcription regulation, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P25440
• Total number of polymer chains: 1
• Total formula weight: 14337.51

Authors

Tallant, C.,Baud, M.,Lin-Shiao, E.,Chirgadze, D.Y.,Ciulli, A. (deposition date: 2014-05-19, release date: 2014-10-29, Last modification date: 2023-09-20)

• Primary citation: Baud, M.G.,Lin-Shiao, E.,Cardote, T.,Tallant, C.,Pschibul, A.,Chan, K.H.,Zengerle, M.,Garcia, J.R.,Kwan, T.T.,Ferguson, F.M.,Ciulli, A.; Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.; Science, 346:638-641, 2014; PubMed: 25323695; DOI: 10.1126/science.1249830

Experimental method

X-RAY DIFFRACTION (1.7 Å)